Angiolymphoid Hyperplasia with Eosinophilia Associated to a Squamous Cell Carcinoma of the Ear

Lugo-Janer, Alexander; Montalvo, Lillian; Ruiz-Santiago, Hiram; Sánchez, Jorge

doi:10.1097/00042728-200410000-00019

Cited by 3 publications

(3 citation statements)

References 7 publications

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“…3 Microscopically, it is comprised of subcutaneous nodules with abnormal capillary vasculature growth near muscle arteries with increased reticulin formation and rare fibrosis 1,2,4,5,6 associated with an immature fibrovascular stroma with lymphocytic infiltrate, eosinophils with mastocytes, and mucinous deposits in the histologic sections. 3 Kempf mentioned this medical condition as a lymphoproliferative disorder of CD4T cells. 8 Endo et al, as well, described a high metabolic rate of the endothelial cells.…”

Section: Discussionmentioning

confidence: 99%

Angiolymphoid Hyperplasia of the External Auditory Canal; Reconstruction of a Complex Defect

Fuentes

González

2021

Ear Nose Throat J

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Angiolymphoid hyperplasia (AH) was first described by Wells and Whimster in 1969 as a benign vasoproliferative pathology with a varied infiltrate of eosinophils, lymphocytes, and plasmatic cells. Clinical presentation has been described in the literature as small red-bluish nodules, less than 3 cm in diameter that can bleed in 25% of the cases and be pruritic and painful in 37% and 20% of the cases, respectively. Particularly, AH can appear in the ear; nevertheless, other regions have been affected, including the scalp, lips, tongue, orbit, muscle, and bone. Most of these cases have occurred in adults with an unknown etiology; however, an inflammatory process has been associated in approximately 20% with eosinophilia. No malignancy has been reported.

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Section: Discussionmentioning

confidence: 99%

Angiolymphoid Hyperplasia of the External Auditory Canal; Reconstruction of a Complex Defect

Fuentes

González

2021

Ear Nose Throat J

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“…25 Occasional coexistence of ALHE with scabies infestation has also been reported. 26 There is also an association of ALHE with SCC in which the removal of the tumor apparently induced regression of the ALHE, 27 as well as a case of ALHE co-existing with a basosquamous carcinoma. 28 Additionally there are at least 2 cases in which the histopathologic pattern of ALHE mimicked an angiosarcoma, including an infiltration of the dermis by infiltrative blood vessels of varying sizes, lined by atypical endothelial cells.…”

Section: Discussionmentioning

confidence: 99%

Three unusual histopathological presentations of angiolymphoid hyperplasia with eosinophilia

Fernández-Flores

2017

J Cutan Pathol

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Angiolymphoid hyperplasia with eosinophilia (ALHE) is a poorly understood benign vasculoproliferative disorder. Histopathologically, the lesions are composed of a dermal or subcutaneous proliferation of blood vessels of varying sizes with plump and bland endothelial cells, which often show vacuolization and protrusion of the cytoplasm into the lumen. The vascular proliferation is admixed with a diffuse inflammatory infiltrate composed of lymphocytes, eosinophils and mast cells. Lymphoid follicles with germinal centers can sometimes be seen. In addition, fibrosis is a common accompanying feature. Some clinical and histopathological variants of ALHE have already been described in the literature. In this report, we present 3 rare associations of ALHE that have not been previously described. Case 1 was a 73-year-old woman with a lesion on her right medial thigh. Examination showed ALHE admixed with a chronic lymphocytic leukemic (CLL) infiltrate. Case 2 was a 55-year-old woman with a lesion on her right anterior ankle, which was a syringocystadenoma papilliferum co-existing with an ALHE. Case 3 was a 54-year-old man with a lesion on the left medial thigh, which showed overlapping features of IgG4-related disease associated with areas of ALHE. Given these multiple and diverse associations, it seems likely that ALHE may be a reactive rather than neoplastic process.

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“…Un caso de ALHE fue comunicado en relación topográfica con un carcinoma de células escamosas de piel, que regresó espontá-neamente una vez extirpada la neoplasia maligna. Esto supone la participación de factores angiogénicos en el desarrollo de ALHE 5 . Se caracteriza histológicamente por proliferación de vasos sanguíneos de paredes engrosadas tapizados por células endoteliales prominentes, infiltración del intersticio por células inflamatorias crónicas, principalmente eosinófilos y la presencia de folículos de células linfoides con centros germinativos 4 .…”

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Hiperplasia angiolinfoidea con eosinofilia: Presentación de un caso en cavidad oral y revisión de la literatura

F¹,

2007

Rev. méd. Chile

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Angiolymphoid Hyperplasia with Eosinophilia Associated to a Squamous Cell Carcinoma of the Ear

Cited by 3 publications

References 7 publications

Angiolymphoid Hyperplasia of the External Auditory Canal; Reconstruction of a Complex Defect

Angiolymphoid Hyperplasia of the External Auditory Canal; Reconstruction of a Complex Defect

Three unusual histopathological presentations of angiolymphoid hyperplasia with eosinophilia

Hiperplasia angiolinfoidea con eosinofilia: Presentación de un caso en cavidad oral y revisión de la literatura

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