Angiolymphoid Hyperplasia with Eosinophilia on the Palm

Abstract

Angiolymphoid hyperplasia with eosinophilia (ALHE) is an uncommon dermal angioproliferating tumor, characterized by red to brown papules or nodules on the head and neck, though also occurring in the mouth, trunk, extremities and inguinal area. The palm is a very unusual site for ALHE, and there have been very few cases reported globally thus far. ALHE can be pruritic and painful and histopathologic findings show vascular proliferation with infiltration of eosinophils and lymphocytes in the dermis. Plump endothelial cells protrude into the lumen. We report a case of ALHE occurring at an unusual site, the right palm, in a 62-year-old man, who had suffered from a solitary pinkish-colored, central depressed round hyperkeratotic plaque on his palm for 4 years. On the basis of clinical and histopathologic data, a diagnosis of ALHE was made. To our knowledge, this is the first report of ALHE on the palm in Korean dermatologic literature.

Signet Ring Cell Melanocytic Nevus: Report of a Case Over Trichilemmal Cyst and Review of the Literature

“…In addition, immunohistochemical staining for Factor VIII-related antigen or CD34 shows positive reactions in these lesions. 27 Many cutaneous neoplasms exhibiting cells with signet ring morphology, such as squamous cell carcinoma, apocrine hidradenoma, cylindroma, basal cell carcinoma and melanocytic nevus, have intracytoplasmic vacuoles that are negative with PAS, colloidal iron, cytokeratin, CEA, and vimentin. In all these cases, electron microscopy shows only empty spaces as a result of the coalescence of intracytoplasmic vacuoles and not by accumulation of secretory products.…”

“…6,10,15 In summary, we emphasize the importance of S-100 and melan A immunostaining of signet ring melanocytes, especially the S-100 nuclear staining pattern, to recognize this particular variant of melanocytic nevus. [6][7][8][9][10][11][12][13][14][15] PAS2, mucicarmine2/S100+, melan A+, Vimentin+, HMB-456 Primary signet ring cell carcinoma [16][17][18] PAS+, PAS-digest+, alcian blue+, mucicarmine+/CKCAM5.2+, CKAE1/3+, CK7+, CK34bE12+, EMA+, CEA+, p63+, MUC-1+, CK206, GCDFP15+ Metastatic signet ring cell gastric or colorectal carcinoma 19,20 PAS+, mucicarmine+/CKAE1/3+, CK20+, CK18+, GCDFP152, CK72, synaptophysin2, p632 Signet ring T-cell lymphoma 21 LCA2, CD3+, CD5+, CD8+ Signet ring B-cell lymphoma 22 LCA2, CD20+, CD10+, kappa/lambda light chain restriction Signet ring squamous cell carcinoma 23 CKAE1/3+, CK34bE12+, p63+, EMA+ Signet ring cell basal cell carcinoma 24 CKAE1/3+, CKCAM 5.2+, SMA+, EMA+, GFAP+ Histiocytoid hemangiomas, angiosarcomas, or epithelioid angiomatous neoplasms [25][26][27] PAS+ (no mucin)/Factor VIII+, CD34+…”