Angiolymphoid hyperplasia with eosinophilia versus Kimura's disease: a case report and a clinical and histopathological comparison

Bastos, Julien Totti de; Rocha, Camila Roos Mariano da; Silva, Priscila Mara Chaves e; Freitas, Bruno Messias Pires de; Cassia, Flávia de Freire; Avelleira, João Carlos Regazzi

doi:10.1590/abd1806-4841.20175318

Cited by 26 publications

(27 citation statements)

References 7 publications

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“…Adenolymphomas are often discovered during a superficial parotidectomy and exhibit marked enhancement in early stages. The density decreases rapidly in cases of delayed diagnosis and density may be heterogeneous in some cases (30). In the present study, low-density areas were observed in lesions.…”

Section: Eosinophil Granulocyte Count On Admissionsupporting

confidence: 48%

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Computerized tomography features and clinicopathological analysis of Kimura disease in head and neck

et al. 2018

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The aim of the current study was to discuss and analyze computerized tomography (CT) features and clinicopathological characteristics of patients with Kimura disease in head and neck. CT and clinicopathological data of 12 patients with Kimura disease diagnosed between May 2011 and May 2015 were analyzed. The mean age was 43.9 years and the disease course varied from 1 week-20 years. The mean absolute value of eosinophil granulocytes was 1.95×10/l. Multiple nodules were detected in 4 patients with Kimura disease. Main symptoms included multiple enlarged lymph nodes in neck and submaxillary regions. CT imaging of nodular lesions revealed a clear boundary, with moderate to marked homogeneous enhancement. Diffuse mass lesions were observed in 6 patients with Kimura disease. Main symptoms included subcutaneous diffuse soft tissue mass in parotid gland and maxillofacial regions. CT imaging of diffuse mass revealed unclear boundaries, adjacent skin thickness and moderate heterogeneous enhancement. In some cases, the diffuse mass involved soft mass with unclear boundaries. Pathological symptoms of Kimura disease included infiltration of eosinophilia, lymphocytic proliferation, formation of lymphatic follicles and variable degrees of fibrosis and vascular proliferation. Diagnosis of Kimura disease in head and neck regions may be improved based on lesions with clear or unclear boundaries, homogeneous or heterogeneous enhancement, with or without lymphadenectasis and by the presence of peripheral blood eosinophilia. However, a final diagnosis relies on a pathological examination.

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Section: Eosinophil Granulocyte Count On Admissionsupporting

confidence: 48%

“…Pleomorphic adenomas and adenolymphomas are the most common benign tumors. Pleomorphic adenomas are often single, with delayed enhancement (30). Adenolymphomas are usually found in elderly males.…”

Section: Eosinophil Granulocyte Count On Admissionmentioning

confidence: 99%

Computerized tomography features and clinicopathological analysis of Kimura disease in head and neck

et al. 2018

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“…It is a systemic immunological process characterized by lymphadenopathy, eosinophilia and increased serum levels of IgE. Renal disease and asthma are commonly present [7]. Histologically, florid lymphoid follicles and eosinophilic infiltrates are typical histological findings of Kimura disease [7].…”

Section: Discussionmentioning

confidence: 99%

“…Differential diagnosis must be made between ALHE and Kimura disease which were thought to be the same pathology in the past [1, 7].…”

Section: Introductionmentioning

confidence: 99%

Angiolymphoid Hyperplasia with Eosinophilia Located on the Forehead: A Possible Association with Oral Contraceptive Use?

Theofilou¹,

Scolozzi²,

Lombardi³

2019

Dermatopathology

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Angiolymphoid hyperplasia with eosinophilia (ALHE) is an uncommon benign vasoproliferative tumor characterized by nodules, papules or plaques localized principally in the head and neck region. Histopathological examination reveals hyperplastic blood vessels lined by large endothelial cells, accompanied by an infiltrate of inflammatory cells including eosinophils. The pathogenetic mechanism remains unclear, although different theories have been proposed. Various treatment strategies have been described, but surgery remains the treatment of choice. We describe the case of a young woman with ALHE taking an oral contraceptive pill suggesting a possible etiopathogenetic relationship.

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“…Both share significant overlap in clinical symptoms (soft tissue masses in the head and neck region) but can be distinguished by both clinical and histologic features. Systemic manifestations are rarely found in ALHE and therefore kidney involvement is more suggestive for KD [128]. Coexisting renal disease is common in KD and described in about 12–18% of the patients with about two-thirds of them developing nephrotic syndrome [33].…”

Section: Eosinophilia In Kidney Diseasementioning

confidence: 99%

Eosinophilia and Kidney Disease: More than Just an Incidental Finding?

Gauckler

Smıth

Mayer

et al. 2018

JCM

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Peripheral blood eosinophilia (PBE), defined as 500 eosinophils or above per microliter (µL) blood, is a condition that is not uncommon but often neglected in the management of patients with chronic kidney disease (CKD), acute kidney injury (AKI), or patients on renal replacement therapy (RRT). The nature of PBE in the context of kidney diseases is predominantly secondary or reactive and has to be distinguished from primary eosinophilic disorders. Nonetheless, the finding of persistent PBE can be a useful clue for the differential diagnosis of underdiagnosed entities and overlapping syndromes, such as eosinophilic granulomatosis with polyangiitis (EGPA), IgG4-related disease (IgG4-RD), acute interstitial nephritis (AIN), or the hypereosinophilic syndrome (HES). For patients on RRT, PBE may be an indicator for bio-incompatibility of the dialysis material, acute allograft rejection, or Strongyloides hyperinfection. In a subset of patients with EGPA, eosinophils might even be the driving force in disease pathogenesis. This improved understanding is already being used to facilitate novel therapeutic options. Mepolizumab has been licensed for the management of EGPA and is applied with the aim to abrogate the underlying immunologic process by blocking interleukin-5. The current article provides an overview of different renal pathologies that are associated with PBE. Further scientific effort is required to understand the exact role and function of eosinophils in these disorders which may pave the way to improved interdisciplinary management of such patients.

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Angiolymphoid hyperplasia with eosinophilia versus Kimura's disease: a case report and a clinical and histopathological comparison

Cited by 26 publications

References 7 publications

Computerized tomography features and clinicopathological analysis of Kimura disease in head and neck

Computerized tomography features and clinicopathological analysis of Kimura disease in head and neck

Angiolymphoid Hyperplasia with Eosinophilia Located on the Forehead: A Possible Association with Oral Contraceptive Use?

Eosinophilia and Kidney Disease: More than Just an Incidental Finding?

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