Angiomyolipome épithélioïde rénal

Lopater, J.; Daniel, Laurent; Akiki, Akram; Boissier, R.; Lechevallier, É.; Coulange, C.

doi:10.1016/j.purol.2009.01.010

Cited by 12 publications

(22 citation statements)

References 8 publications

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“…Melanosome is usually produced in skin, hair and eye involving in the synthesis and dispersion of melanin to neighboring keratinocytes [24]. Although melanosome was found in malignant pigmented epithelioid tumor cells of kidney [25,26], there is no report for its existence in normal kidney. Furthermore, there are no melanosome-specific proteins, such as tyrosinase-related proteins (TYRP) and Pmel 17 (SILV) [27,28], examined in this study or the large-scale analysis.…”

Section: Resultsmentioning

confidence: 99%

Comparison of human glomerulus proteomic profiles obtained from low quantities of samples by different mass spectrometry with the comprehensive database

Zhang

Yoshida

et al. 2011

Proteome Sci

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BackgroundWe have previously constructed an in-depth human glomerulus proteome database from a large amount of sample for understanding renal disease pathogenesis and aiding the biomarker exploration. However, it is usually a challenge for clinical research to get enough tissues for large-scale proteomic characterization. Therefore, in this study, we focused on high-confidence proteomics analysis on small amounts of human glomeruli comparable to those obtained from biopsies using different mass spectrometers and compared these results to the comprehensive database.ResultsOne microgram of human glomerular protein digest was analyzed each on five LC- combined mass spectrometers (LIT-TOF, LTQ-Orbitrap, Q-TOF, LIT and MALDI-TOF/TOF) yielding 139, 185, 94, 255 and 108 proteins respectively identified with strict criteria to ensure high confidence (> 99%) and low false discovery rate (FDR) (< 1%). An integrated profile of 332 distinct glomerular proteins was subsequently generated without discerned bias due to protein physicochemical properties (pI and MW), of which around 60% were detected commonly by more than two LC-MS/MS platforms. Comparative analysis with the comprehensive database demonstrated 14 proteins uniquely identified in this study and more than 70% of identified proteins in small datasets were concentrated to the top abundant 500 in the comprehensive database which consists of 2775 non-redundant proteins.ConclusionThis study showed representative human glomerulus proteomic profiles obtained from biopsies through analysis of comparable amounts of samples by different mass spectrometry. Our results implicated that high abundant proteins are more likely to be reproducibly identified in multiple mass spectrometers runs and different mass spectrometers. Furthermore, many podocyte essential proteins such as nephrin, podocin, podocalyxin and synaptopodin were also identified from the small samples in this study. Bioinformatic enrichment analysis results extended our understanding of the major glomerular proteins about their subcellular distributions and functions. The present study indicated that the proteins localized in certain cellular compartments, such as actin cytoskeleton, mitochondrial matrix, cell surface, basolateral plasma membrane, contractile fiber, proteinaceous extracellular matrix and adherens junction, represent high abundant glomerular proteins and these subcellular structures are also highly significantly over-represented in the glomerulus compared to the whole human background.

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Section: Resultsmentioning

confidence: 99%

Comparison of human glomerulus proteomic profiles obtained from low quantities of samples by different mass spectrometry with the comprehensive database

Zhang

Yoshida

et al. 2011

Proteome Sci

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“…Although it has been speculated that PSC preserves better sexual function and continence function, oncological outcome varies in different studies without consensus. Some studies disagreed with this operation due to inferior oncological outcomes [6–9]. Nevertheless, most of these studies did not reveal their own conventional radical cystoprostatectomy data compared to the PSC group.…”

Section: Discussionmentioning

confidence: 99%

Comparisons of Quality of Life and Functional and Oncological Outcomes after Orthotopic Neobladder Reconstruction: Prostate-Sparing Cystectomy versus Conventional Radical Cystoprostatectomy

Chen

Chiang

2017

BioMed Research International

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Objectives To compare health-related quality of life and oncological and functional outcomes on erectile function, continence, and voiding function among bladder patients who underwent orthotopic neobladder reconstruction after prostate-sparing cystectomy (PSC) and conventional radical cystoprostatectomy (CRC). Methods This is a retrospective cohort study from a single surgeon. During 2007 to 2015, we identified 25 of 186 male patients receiving radical cystectomies due to bladder cancer who underwent orthotopic neobladder reconstruction, 14 patients with PSC and the other 11 patients with CRC. International Index of Erectile Function-5 (IIEF-5), International Prostate Symptom Score (IPSS), European Organization for Research and Treatment of Cancer-Quality of Life Questionnaire-Core 30-item questionnaire (EORTC-QLQ-C30), and self-catheterizations were used to evaluate functional outcomes in the baseline and 1 year after operation. Results There were better physical and social functioning scales, less fatigue symptoms, better IIEF (16 versus 3.7, p = 0.01), and less self-catheterization rate (33% versus 89% p = 0.006) in the PSC group. The oncologic outcomes were the same between two groups. Conclusions For selected patients with bladder cancer who underwent neobladder reconstruction, prostate-sparing cystectomy provided better sexuality preservation, less daily self-catheterization, and better physical function and social function scales without compromising overall survival.

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“…La néphrectomie totale élargie devrait être indiquée pour les AMLeR malins avec envahissement locorégional ou métastatique. Le traitement adjuvant ou de première ligne à base de chimiothérapie ou de thérapie ciblée doit être discuté en RCP [7]. …”

Section: Discussionunclassified