Angiomyomatous Hamartoma of Inguinal Lymph Nodes

Piedimonte, Andrea; Nictolis, Michele De; Lorenzini, Paola; Sperti, Vanessa; Bertani, Aldo

doi:10.1097/01.prs.0000197912.09044.37

Cited by 17 publications

(12 citation statements)

References 3 publications

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“…Angiomyomatous hamartoma of the lymph node was first described by Chan et al . [ 1 ] in 1992 as a distinctive vascular hamartomatous lesion that primarily occurs in inguinal and femoral lymph nodes [ 2 , 3 ]. Occasional cases have been reported in popliteal and cervical lymph nodes [ 4 , 5 ].…”

Section: Discussionmentioning

confidence: 99%

Angiomyomatous Hamartoma of Popliteal Lymph Node: An Unusual Entity

Mridha

Ranjan

Kinra

et al. 2015

J Pathol Transl Med

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Section: Discussionmentioning

confidence: 99%

Angiomyomatous Hamartoma of Popliteal Lymph Node: An Unusual Entity

Mridha

Ranjan

Kinra

et al. 2015

J Pathol Transl Med

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“…Some cases of AH of the inguinal lymph nodes have been reported to be associated with lymphedema of the ipsilateral limb. [1][2][3][4] However, lymphedema appears to be caused by impaired lymphatic flow due to AH, rather than being a cause of AH. Bourgeois et al 2 suggested that the destruction of nodal sinuses by vascular and stromal alterations may represent impairment of the lymphatic flow across the affected lymph node and may contribute to the clinical expression of lymphedema in the extremities.…”

Section: Discussionmentioning

confidence: 99%

“…It was first described by Chan et al 1 in 1992. It typically affects lymph nodes in the inguinal region; [2][3][4][5] however, cases involving cervical or femoral lymph nodes have also been described. 6,7 AH is characterized by replacement of the nodal parenchyma by haphazardly arranged smooth muscle cells and fibrous tissue, as well as a proliferation of abnormal blood vessels.…”

mentioning

confidence: 99%

Angiomyomatous Hamartoma of Popliteal Lymph Nodes Occurring in Association with Diffuse Pigmented Villonodular Synovitis of Knee

Kim

Lee

et al. 2011

Korean J Pathol

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We report the first case of an angiomyomatous hamartoma (AH) of the popliteal lymph nodes (LNs) occurring in association with diffuse pigmented villonodular synovitis (PVNS) of the knee. AH is a rare benign vascular disease with a predisposition for the LNs of the inguinal region. Twenty-five cases of AH have been reported to date; however, the precise pathogenesis is still undetermined. In the present case, an open synovectomy revealed two of three popliteal LNs in close proximity to the extra-articular component of diffuse PVNS. These LNs demonstrated irregularly distributed thick-walled blood vessels in the hilum. These vessels extended into the medulla and cortex and were associated with haphazardly arranged smooth muscle cells in the sclerotic stroma. These findings are compatible with an AH. Our observations raise the possibility that AH of the popliteal LNs may represent an abnormal proliferative reaction against the inflammatory process caused by PVNS of the knee.

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“…Some authors suggested that it represents a proliferative vascular and smooth muscle response either to chronic impairment of nodal lymphatic flow or to previous nodal inflammation [1,5]. Others proposed that it is caused by a malformation associated with congenital damage to the lymphatic area [7]. The histological features point to a disordered angiogenic process arising from hilar blood vessels, presumably the hilar vein and its branches [6].…”

Section: Discussionmentioning

confidence: 99%

Angiomyomatous Hamartoma of a Lymph Node - A Possible Late Complication of Radiotherapy? Case Report and Review of the Literature

Yemini¹,

Wolff-Bar²,

Gutman³

2016

Arc Cas Rep CMed

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Angiomyomatous hamartoma (AMH) of a lymph node is a benign vascular disorder of unknown etiology. We present a case of an inguinal AMH associated with previous lymph node dissection and radiotherapy to the same area. Preo-perative fine needle aspiration was not diagnostic. Surgical excision was successful, but the procedure got complicated by a high-output lymphatic fistula. Later, spontaneous closure of the fistula led to secondary lymphedema. AMH seems to be a rare nodal condition, commonly occurring in the inguinal region. The pathogenesis of AMH of a lymph node is still unclear. AMH may be related to previous radiotherapy or to chronically impair lymphatic flow. Being a benign process, the need for surgery is unclear, as it may further impede drainage and probably needs a more tedious surgical technique (i.e intra-operative lymphatic mapping with a dye, ties rather than diathermy etc). Recognition of this entity is important for the differential diagnosis of other angiomatous benign and malignant lymph node tumors, as well as for reconsideration of the need for surgery and the applied surgical technique.

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Angiomyomatous Hamartoma of Inguinal Lymph Nodes

Cited by 17 publications

References 3 publications

Angiomyomatous Hamartoma of Popliteal Lymph Node: An Unusual Entity

Angiomyomatous Hamartoma of Popliteal Lymph Node: An Unusual Entity

Angiomyomatous Hamartoma of Popliteal Lymph Nodes Occurring in Association with Diffuse Pigmented Villonodular Synovitis of Knee

Angiomyomatous Hamartoma of a Lymph Node - A Possible Late Complication of Radiotherapy? Case Report and Review of the Literature

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