Purpose: The aim of this study was to determine the safety and efficacy of stenting for the treatment of symptomatic severe stenotic or occluded subclavian arterial lesions.Methods: Between September 2007 and April 2010, 11 patients (age range, 31 to 78 y; mean, 61.7 ± 5.9 y) with 11 severe stenotic or occluded (Z85% to 100%) subclavian arterial lesions were treated through insertion of stents. All patients presented with symptomatic vertebrobasilar steal syndrome and/or arm claudication. Follow-up angiography was performed to investigate stent patency and clinical follow-up data were categorized as fully recovered, improved, unchanged, or worsened.Results: All lesions, including severe stenosis in 8 patients and complete occlusion in 3 patients, were successfully recanalized. Vertebral protection was used in 3 patients. No procedure-related complications occurred. The mean difference in systolic blood pressure between the upper limbs decreased from 41.4 ± 9.7 mm Hg preprocedure to 7.4 ± 3.9 mm Hg postprocedure. At the end of angiographic follow-up (mean, 10.1 ± 4.6 mo), all of the stented arteries maintained good patency except one in which mild restenosis (35%) was observed. Clinical follow-up (mean, 15.5 ± 7.9 mo) revealed no recurrence of symptoms.Conclusions: Endovascular stenting is an effective method for the recanalization of severe stenotic or totally occluded subclavian arterial lesions, with an excellent mid-term patency rate based on angiographic follow-up.