Circulation Journal Official Journal of the Japanese Circulation Society http://www. j-circ.or.jp espite remarkable progress in the technique of percutaneous coronary intervention (PCI), the recanalization of chronic total occlusion (CTO) of native coronary artery remains as one of the major challenges in interventional cardiology. 1-4 The success rates of top level operators are still considerably lower than those achieved in non-occluded coronary arteries or acutely occluded arteries by average-volume operators. 5-7One of the major hurdles of CTO PCI is the inability to visualize the exact vessel course, size, and hardness because of the inability to obtain luminal continuity on traditional coronary angiography. Multidetector computed tomography (MDCT) has been used as a valuable non-invasive tool for evaluation of coronary artery atherosclerotic plaque. 8-14 Furthermore, recent developments in MDCT technology, including increased detectors and dedicated coronary artery analysis software, have enabled sophisticated volumetric plaque analysis on intravascular ultrasound (IVUS). 15, 16 We therefore reasoned that MDCT can provide additional information beyond coronary angiography, and can predict the success of CTO PCI. Background: The purpose of the present study was to investigate whether multidetector computed tomography (MDCT) can identify the nature of chronic total occlusion (CTO) plaque, which cannot be measured quantitatively using traditional coronary angiography, and predict the success of percutaneous coronary intervention (PCI).