Angiopoietin-1, angiopoietin-2 and Tie-2 receptor expression in human dermal wound repair and scarring

Staton, Carolyn A.; Valluru, Manoj K.; Hoh, L.; Reed, Malcolm; Brown, Nicola J.

doi:10.1111/j.1365-2133.2010.09940.x

Cited by 54 publications

(43 citation statements)

References 26 publications

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“…For example, after tissue injury, healing occurs through an initial phase of angiogenesis followed by tissue fibrosis or regeneration. In both instances, the early phase is associated with enhanced expression of Angpt2 and Vegfa expression locally around the wound; Vegfa is upregulated in keratinocytes, whereas Angpt2 is increased in endothelial cells (13,26). Accordingly, we induced a controlled tissue injury using an ear punch (27).…”

Section: Discussionmentioning

confidence: 99%

Angiopoietin-1 is essential in mouse vasculature during development and in response to injury

et al. 2011

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Angiopoietin-1/Tek signaling is a critical regulator of blood vessel development, with conventional knockout of angiopoietin-1 or Tek in mice being embryonically lethal due to vascular defects. In addition, angiopoietin-1 is thought to be required for the stability of mature vessels. Using a Cre-Lox conditional gene targeting approach, we have studied the role of angiopoietin-1 in embryonic and adult vasculature. We report here that angiopoietin-1 is critical for regulating both the number and diameter of developing vessels but is not required for pericyte recruitment. Cardiac-specific knockout of angiopoietin-1 reproduced the phenotype of the conventional knockout, demonstrating that the early vascular abnormalities arise from flow-dependent defects. Strikingly, deletion in the entire embryo after day E13.5 produced no immediate vascular phenotype. However, when combined with injury or microvascular stress, angiopoietin-1 deficiency resulted in profound organ damage, accelerated angiogenesis, and fibrosis. These findings redefine our understanding of the biological roles of angiopoietin-1: it is dispensable in quiescent vessels but has a powerful ability to modulate the vascular response after injury.

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Section: Discussionmentioning

confidence: 99%

Angiopoietin-1 is essential in mouse vasculature during development and in response to injury

et al. 2011

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“…We also observed that ANGPT1 showed the statistically significant decrease in mRNA expression 1 day after the skin incisions. These factors have been reported to promote angiogenesis [6,[19][20][21]23,27,33,34], and their decreases may indicate that complex mechanisms may be involved in our skin wound system.…”

Section: Discussionmentioning

confidence: 99%

“…In this study, we examined mRNA expressions of factors possibly involved in angiogenesis in the rat skin incision wounds, using TaqMan probes. The factors studied are: angiopoietin (ANGPT) 1 and 2 [6][7][8], cadherin 5 (CDH5) [9], granulocyte-macrophage colony stimulating factor (CSF2/GM-CSF) [10][11][12][13], granulocyte colony stimulating factor http://dx.doi.org/10.1016/j.legalmed.2015.02.007 1344-6223/Ó 2015 Elsevier Ireland Ltd. All rights reserved.…”

Section: Introductionmentioning

confidence: 99%

The mRNA expressions and immunohistochemistry of factors involved in angiogenesis and lymphangiogenesis in the early stage of rat skin incision wounds

Kameyama¹,

Udagawa²,

Hoshi³

et al. 2015

Legal Medicine

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“…60 Angiopoietin-2 is expressed from day 3 of dermal wound healing 61 and is present during reepithelialization, granulation tissue formation, and remodeling. 62,63 Binding of the angiopoietin-2 FBG domain to Tie2 receptor mediates the destabilization of existing vessels promoting vascular remodeling in the presence of vascular endothelial growth factor (VEGF). 64 In addition, it can promote endothelial cell survival.…”

Section: Patterns [Damps]mentioning

confidence: 99%

Fibrinogen-Related Proteins in Tissue Repair: How a Unique Domain with a Common Structure Controls Diverse Aspects of Wound Healing

Zuliani-Alvarez

Midwood

2015

Advances in Wound Care

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Fibrinogen-related proteins (FRePs) comprise an intriguing collection of extracellular molecules, each containing a conserved fibrinogen-like globe (FBG). This group includes the eponymous fibrinogen as well as the tenascin, angiopoietin, and ficolin families. Many of these proteins are upregulated during tissue repair and exhibit diverse roles during wound healing. An increasing body of evidence highlights the specific expression of a number of FRePs following tissue injury and infection. Upon induction, each FReP uses its FBG domain to mediate quite distinct effects that contribute to different stages of tissue repair, such as driving coagulation, pathogen detection, inflammation, angiogenesis, and tissue remodeling. Despite a high degree of homology among FRePs, each contains unique sequences that enable their diversification of function. Comparative analysis of the structure and function of FRePs and precise mapping of regions that interact with a variety of ligands has started to reveal the underlying molecular mechanisms by which these proteins play very different roles using their common domain. Fibrinogen has long been used in the clinic as a synthetic matrix serving as a scaffold or a delivery system to aid tissue repair. Novel therapeutic strategies are now emerging that harness the use of other FRePs to improve wound healing outcomes. As we learn more about the underlying mechanisms by which each FReP contributes to the repair response, specific blockade, or indeed potentiation, of their function offers real potential to enable regulation of distinct processes during pathological wound healing.

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Angiopoietin-1, angiopoietin-2 and Tie-2 receptor expression in human dermal wound repair and scarring

Cited by 54 publications

References 26 publications

Angiopoietin-1 is essential in mouse vasculature during development and in response to injury

Angiopoietin-1 is essential in mouse vasculature during development and in response to injury

The mRNA expressions and immunohistochemistry of factors involved in angiogenesis and lymphangiogenesis in the early stage of rat skin incision wounds

Fibrinogen-Related Proteins in Tissue Repair: How a Unique Domain with a Common Structure Controls Diverse Aspects of Wound Healing

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