Angiopoietin-like 2 is a potential biomarker for diabetic foot patients

Wang, Yan; Zheng, Zhaohui; Yang, Yuxian; Lang, Jianan; Zhang, Ning; Yang, Longyan; Zhao, Dong

doi:10.1186/s12902-020-00657-7

Cited by 6 publications

(6 citation statements)

References 26 publications

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“…48 Recent findings have also revealed higher angiopoietin-2 levels in patients with DFUs stressing its potential as a biomarker for patients with DFU. 49 Although illness perception was a predictive healing factor, surprisingly, emotional distress (i.e., perceived stress, anxiety and depression) did not emerge as a predictive psychological factor for DFU healing. Given that the relationship between psychological distress and wound healing impairment is already established, 15,16 further research is required to confirm and better understand this result.…”

Section: Discussionmentioning

confidence: 90%

“…Accordingly, increased angiopoietin‐2 levels have been reported in mouse models of type 2 DM with myocardial ischemia, 47 as well as in the vitreous of patients with proliferative diabetic retinopathy 48 . Recent findings have also revealed higher angiopoietin‐2 levels in patients with DFUs stressing its potential as a biomarker for patients with DFU 49 . Although illness perception was a predictive healing factor, surprisingly, emotional distress (i.e., perceived stress, anxiety and depression) did not emerge as a predictive psychological factor for DFU healing.…”

Section: Discussionmentioning

confidence: 97%

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Healing profiles in patients with a chronic diabetic foot ulcer: An exploratory study with machine learning

Pereira,

Vilaça,

Braga

et al. 2023

Wound Repair Regeneration

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Diabetic foot ulcers (DFU) are one of the most frequent and debilitating complications of diabetes. DFU wound healing is a highly complex process, resulting in significant medical, economic and social challenges. Therefore, early identification of patients with a high‐risk profile would be important to adequate treatment and more successful health outcomes. This study explores risk assessment profiles for DFU healing and healing prognosis, using machine learning predictive approaches and decision tree algorithms. Patients were evaluated at baseline (T0; N = 158) and 2 months later (T1; N = 108) on sociodemographic, clinical, biochemical and psychological variables. The performance evaluation of the models comprised F1‐score, accuracy, precision and recall. Only profiles with F1‐score >0.7 were selected for analysis. According to the two profiles generated for DFU healing, the most important predictive factors were illness representations on T1 IPQ‐B (IPQ‐B ≤ 9.5 and < 10.5) and the DFU duration (≤ 13 weeks). The two predictive models for DFU healing prognosis suggest that biochemical factors are the best predictors of a favorable healing prognosis, namely IL‐6, microRNA‐146a‐5p and PECAM‐1 at T0 and angiopoietin‐2 at T1. Illness perception at T0 (IPQ‐B ≤ 39.5) also emerged as a relevant predictor for healing prognosis. The results emphasize the importance of DFU duration, illness perception and biochemical markers as predictors of healing in chronic DFUs. Future research is needed to confirm and test the obtained predictive models.

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Section: Discussionmentioning

confidence: 90%

Section: Discussionmentioning

confidence: 97%

Healing profiles in patients with a chronic diabetic foot ulcer: An exploratory study with machine learning

Pereira,

Vilaça,

Braga

et al. 2023

Wound Repair Regeneration

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“…In addition, the reduction of proportion of angiopoietins‐1/angiopoietins‐2 leads to the reduction of bone marrow endothelial progenitor cells. This transformation results in the impairment of the neovascularization capacity in diabetic wound 39,40 . In general, the state of diabetes mellitus causes a large number of neovascularization defects such as insufficient angiogenesis.…”

Section: Pathogenesis Of Dfumentioning

confidence: 99%

“…This transformation results in the impairment of the neovascularization capacity in diabetic wound. 39 , 40 In general, the state of diabetes mellitus causes a large number of neovascularization defects such as insufficient angiogenesis. These defects occur in the early and late stages of wound healing, as well as affect the proliferation and maturation of blood vessels.…”

Section: Pathogenesis Of Dfumentioning

confidence: 99%

Advanced multifunctional hydrogels for diabetic foot ulcer healing: Active substances and biological functions

Li,

Leng,

Liu

et al. 2024

Journal of Diabetes

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AimHydrogels with excellent biocompatibility and biodegradability can be used as the desirable dressings for the therapy of diabetic foot ulcer (DFU). This review aimed to summarize the biological functions of hydrogels, combining with the pathogenesis of DFU.MethodsThe studies in the last 10 years were searched and summarized from the online database PubMed using a combination of keywords such as hydrogel and diabetes. The biological functions of hydrogels and their healing mechanism on DFU were elaborated.ResultsIn this review, hydrogels were classified by their active substances such as drugs, cytokines, photosensitizers, and biomimetic peptide. Based on this, the biological functions of hydrogels were summarized by associating the pathogenesis of DFU, including oxidative stress, chronic inflammation, cell phenotype change, vasculopathy, and infection. This review also pointed out some of the shortcomings of hydrogels in present researches.ConclusionsHydrogels were classified into carrier hydrogels and self‐functioning hydrogels in this review. Besides, the functions and components of existing hydrogels were clarified to provide assistance for future researches and clinical applications.image

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“…Angiopoietin-like protein 2 (ANGPTL2), a kind of 64-kDa glycosylated protein that belongs to the angiopoietin-like family, is known to be capable of promoting angiogenesis and anti-apoptosis as it contains a fibrinogen-like domain similar to angiopoietin in structure [ 18 ]. In addition, ANGPTL2 is established as a pro-inflammatory protein associated with states of chronic inflammation, such as diabetes, atherosclerosis, and cancer, and is further widely expressed in visceral adipose tissues [ 19 ].…”

Section: Introductionmentioning

confidence: 99%

miR-124-3p Combined with ANGPTL2 Has High Diagnostic Values for Obese and Nonobese Polycystic Ovary Syndrome

Dai

Liu

et al. 2022

International Journal of Endocrinology

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Polycystic ovary syndrome (PCOS) is a hormonal disorder that affects 5–20% of women of reproductive age. Interestingly, serum miR-124-3p and ANGPTL2 are differentially expressed in PCOS patients. Accordingly, this study set out to explore the clinical roles of serum miR-124-3p/ANGPTL2 in PCOS. Firstly, miR-124-3p/ANGPTL2 expression patterns were detected in the serum of 102 PCOS patients and 100 healthy subjects. miR-124-3p or/and ANGPTL2 diagnostic efficacy on PCOS was further analyzed, in addition to the measurement of lipid metabolism, glucose metabolism, sex hormone indexes, and inflammation levels. Correlations between serum miR-124-3p/ANGPTL2 expressions and age, BMI, Ferriman–Gallwey score, lipid metabolism, glucose metabolism, sex hormone indexes, TNF-α, and IL-6 in PCOS patients were determined. The expression correlation and binding relationship of ANGPTL2 and miR-124-3p were identified. In addition, miR-124-3p was downregulated and ANGPTL2 was upregulated in the serum of obese and nonobese PCOS patients. miR-124-3p expression was found to be negatively correlated with Ferriman–Gallwey score and serum total testosterone (T), and negatively related to prolactin (PRL). ANGPTL2 expression was positively correlated with FNS and inversely linked with PRL. TNF-α and IL-6 were negatively correlated with miR-124-3p, but positively correlated with ANGPTL2. Furthermore, there was a negative correlation and a targeting relationship between ANGPTL2 and miR-124-3p expression in the serum of obese and nonobese PCOS patients. Collectively, our findings indicated that miR-124-3p might target ANGPTL2 expression in obese and nonobese PCOS patients, and further underscored the diagnostic value of their combination.

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Angiopoietin-like 2 is a potential biomarker for diabetic foot patients

Cited by 6 publications

References 26 publications

Healing profiles in patients with a chronic diabetic foot ulcer: An exploratory study with machine learning

Healing profiles in patients with a chronic diabetic foot ulcer: An exploratory study with machine learning

Advanced multifunctional hydrogels for diabetic foot ulcer healing: Active substances and biological functions

miR-124-3p Combined with ANGPTL2 Has High Diagnostic Values for Obese and Nonobese Polycystic Ovary Syndrome

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