Angiopoietin-like protein 4 (ANGPTL4) is related to gestational weight gain in pregnant women with obesity

Abstract

Angiopoietin-like protein 4 (ANGPTL4) is a circulating protein involved in the regulation of adipose tissue metabolism. However, its role in obesity and pregnancy is unknown. To evaluate the relationship between gestational weight gain (GWG) and circulating concentrations of ANGPTL4 in pregnant women with overweight and obesity, weight gain and fasting maternal blood samples of thirty-one pregnant women was drawn at 15, 24 and 32 weeks of gestation. ANGPTL4 concentrations continuously rose throughout gestation, whereas VEGF and leptin did not show the same trend. NEFA and glycerol concentrations remained stable during pregnancy. In contrast, total concentrations of saturated, monounsaturated and n-6 fatty acids, but not n-3 fatty acids, increased with pregnancy. In multiple regression analysis, the increase in plasma ANGPTL4 and decrease in linoleic acid concentrations were the most significant predictors of GWG, although only ANGPTL4 was significantly associated with the weight gain from early pregnancy (area under the ROC curve was 0.80 p < 0.01(95% CI 0.61–0.99)). In conclusion, in pregnant women with overweight and obesity, an increase in plasma ANGPTL4 concentrations throughout pregnancy is positively associated with GWG and could be used as an early marker of increased susceptibility to excess gestational weight gain.

Multiomics Characterization of Preterm Birth in Low- and Middle-Income Countries

“… 38 , 39 However, the predictive model also highlighted a set of proteomic features with no known inflammatory properties that were correlated with features from the inflammatory module. These proteins included protein-arginine deiminase type II (PADI2), a peptidylarginine deiminase that is responsible for protein citrullination and implicated in parturition and sensing infections 40 , 41 ; transferrin receptor (TfR), which is implicated in iron transport; angiopoietin-like 4 (ANGPTL4), which regulates glucose homeostasis and lipid metabolism 42 ; and RARRES2, an adipokine that is increased in metabolic syndrome and gestational diabetes. 43 , 44 …”

“…angiopoietin-like 4 (ANGPTL4), which regulates glucose homeostasis and lipid metabolism 42 ; and RARRES2, an adipokine that is increased in metabolic syndrome and gestational diabetes. 43,44 To ascertain whether observed correlations between these proteins and the inflammatory module reflected biologically relevant inflammatory properties, we examined the capacity of each of these factors to stimulate human peripheral blood leukocytes using an ex vivo mass cytometry assay.…”

Effects of Angiopoietin-Like 3 on Triglyceride Regulation, Glucose Homeostasis, and Diabetes

“…Notably, plasma ANGPTL4 levels significantly increased after weight gain and decreased after weight loss [ 60 ]. In addition, an increase in plasma ANGPTL4 throughout pregnancy was positively associated with gestational weight gain and could be used as an early marker of increased susceptibility to excess gestational weight gain [ 66 ].…”

Leptin–VEGF crosstalk in excess body mass and related disorders: A systematic review

“…127 In pregnant subjects with excess body mass, increasing blood angiopoietin-like protein 4 level throughout pregnancy is associated positively with gestational weight gain and can serve as a marker of susceptibility to excess gestational weight gain, whereas plasma leptin and VEGF do not show such a trend. 128 A study of Leijnse et al demonstrated that leptin may be even associated with pregnancy outcome: Overweight women with adverse pregnancy outcomes had elevated circulating leptin level accompanied with impaired placentation and reduced placental vascularization; no such relationship was found for VEGF. 129 In women with excess body mass and preeclampsia, the serum level of leptin, though not of VEGF or hypoxia-inducible factor 1 (HIF-1), is higher than in BMI-matched subjects without preeclampsia.…”