Angiopoietins in malignancy

Bach, Fiona; Uddin, FJ; Burke, Dermot

doi:10.1016/j.ejso.2006.07.015

Cited by 78 publications

(75 citation statements)

References 49 publications

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“…However, it might be explained as: angiopoietins are involved in the angiogenic switch (Ahmad et al, 2001;Tanaka et al, 2003). Ang-1 stabilises vessels by maintaining pericyte coverage; ang-2 promotes pericyte removal, which in the presence of VEGF facilitates the angiogenic response and in the absence of VEGF induces vessel regression (Moon et al, 2006;Bach et al, 2007;Shim et al, 2007;Winter et al, 2007). Depending on the tumour model, stabilisation of blood vessels by ang-1 may either promote tumour angiogenesis or reduce tumour growth (Metheny-Barlow and Li, 2003).…”

Section: Discussionmentioning

confidence: 99%

Relationship between human tumour angiogenic profile and combretastatin-induced vascular shutdown: an exploratory study

Gaya

Daley²,

Taylor³

et al. 2008

Br J Cancer

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Combretastatin-A4-phosphate (CA4P) acts most effectively against immature tumour vasculature. We investigated whether histological angiogenic profile can explain the differential sensitivity of human tumours to CA4P, by correlating the kinetic changes demonstrated by dynamic MRI (DCE-MRI) in response to CA4P, with tumour immunohistochemical angiogenic markers. Tissue was received from 24 patients (mean age 59, range 32 -73, 18 women, 6 men). An angiogenic profile was performed using standard immunohistochemical techniques. Dynamic MRI data were obtained for the same patients before and 4 h after CA4P. Three patients showed a statistically significant fall in K trans following CA4P, and one a statistically significant fall in IAUGC 60 . No statistically significant correlations were seen between the continuous or categorical variables and the DCE-MRI kinetic parameters other than between ang-2 and K trans (P ¼ 0.044). In conclusion, we found no strong relationships between changes in DCE-MRI kinetic variables following CA4P and the immunohistochemical angiogenic profile.

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Section: Discussionmentioning

confidence: 99%

Relationship between human tumour angiogenic profile and combretastatin-induced vascular shutdown: an exploratory study

Gaya

Daley²,

Taylor³

et al. 2008

Br J Cancer

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“…(30), and oral tongue squamousc cell carcinoma (31). Angiopoietin family members usually regulate the differentiation or invasion of cancer cells through the activation of its receptor tie-2 and downstream tyrosine kinase pathway (5,6,32). However, Angptl4 does not bind to tie-2, but contain motifs structurally conserved in angiopoietins.…”

Section: Discussionmentioning

confidence: 99%

“…there is strong evidence that the angiopoietin family is involved in the regulation of tumour progression, cellular growth, and differentiation (4)(5)(6). Angiopoietin-like 4 (Angptl4) is a member of the family of angiopoietins and is also known as hepatic fibrinogen/angiopoietin-related protein (HeArp) (7), peroxisome proliferator-activated receptor-γ (ppArγ) angiopoietin-related gene (pgAr) (8), or fasting-induced adipose factor (FIAF) (9).…”

Section: Introductionmentioning

confidence: 99%

Expression of angiopoietin-like 4 (ANGPTL4) in human colorectal cancer: ANGPTL4 promotes venous invasion and distant metastasis

Nakayama

Hirakawa²,

Shibata³

et al. 2011

Oncol Rep

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Abstract. there is strong evidence that the angiopoietin family is involved in the regulation of tumour progression. recently, it has been reported that angiopoietin-like 4 (Angptl4) expression in cancer cells promotes the metastatic process by increasing vascular permeability. the present study was conducted to examine Angptl4 expression and its association with clinicopathological factors and prognosis in human colorectal cancers. We examined 144 cases of surgically-resected human colorectal adenocarcinomas by immunohistochemistry, rt-pcr and Western blot analysis. Also, overall survival was investigated. Among 144 cases of adenocarcinoma, 95 cases (66.0%) showed positive staining in the cytoplasm of the carcinoma cells for Angptl4. Histologically, well, moderately, poorly differentiated adenocarcinoma or mucinous carcinoma showed 55.2, 79.3, 61.5 or 44.4% expression of Angptl4, respectively. the expression of Angptl4 was correlated with the depth of tumour invasion (p<0.0005), Vienna classification (category 3-5) (p<0.00005), venous invasion (p<0.0005) and Duke's classification (p<0.005). However, Angptl4 expression was not correlated with overall survival. However, all patients (100%) with distant metastasis showed immunopositivity for Angptl4. the mrnA and the protein expression of Angptl4 were shown in four resected samples and cultured cell lines by rt-pcr or Western blot analysis. These findings suggest that Angptl4 is one of the factors involved in the progression of human colorectal cancer, especially venous invasion and distant metastasis. Introductioncolorectal cancer is one of the most common cancer types in the world today (1). the occurrence and progression of cancer are considered to be a series of genetic events affecting the structure and/or expression of a number of oncogenes, tumour suppressors, and growth factors (2,3). the deep invasive carcinomas, such as colorectal cancer, have higher rates of lymph duct and venous invasions, and lymph node metastasis (3). However, the mechanisms of invasion and metastasis of colorectal cancer are not fully understood.there is strong evidence that the angiopoietin family is involved in the regulation of tumour progression, cellular growth, and differentiation (4-6). Angiopoietin-like 4 (Angptl4) is a member of the family of angiopoietins and is also known as hepatic fibrinogen/angiopoietin-related protein (HeArp) (7), peroxisome proliferator-activated receptor-γ (ppArγ) angiopoietin-related gene (pgAr) (8), or fasting-induced adipose factor (FIAF) (9). Angptl4 is a circulating plasma protein and is expressed in the liver, adipose tissue, placenta, as well as in ischemic tissue (8,9). similar to angiopoietins and other angiopoietin-like proteins, Angptl4 contains an amino-terminal coiled-coil domain and a carboxyl-terminal fibrinogen-like domain (10). Angptl4 induces a strong proangiogenic response, independently of vascular endothelial growth factor (11), and is known to undergo hypoxia-induced gene expression in endothelial cells. this protein is up-regu...

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“…There is strong evidence that the angiopoietin family is involved in the regulation of tumour progression, cellular growth and differentiation (8)(9)(10). Angiopoietin-like 4 (ANGPTL4) is a member of the family of angiopoietins and is known as hepatic fibrinogen/angiopoietin-related protein (HEARP) (11), peroxisome proliferator-activated receptor-Á (PPARÁ) angiopoietin-related gene (PGAR) (12) or fastinginduced adipose factor (FIAF) (13).…”

Section: Introductionmentioning

confidence: 99%

Expression of angiopoietin-like 4 in human gastric cancer: ANGPTL4 promotes venous invasion

Nakayama¹

2010

Oncol Rep

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Abstract. There is strong evidence that the angiopoietin family is involved in the regulation of tumour progression, cellular growth and differentiation. Recently, it has been reported that angiopoietin-like 4 (ANGPTL4) in cancer cell promotes the metastatic process by increasing vascular permeability. To elucidate ANGPTL4 expression and its association with clinicopathological factors and prognosis in human gastric adenocarcinomas, we examined 103 cases of surgicallyresected human gastric adenocarcinoma by immunohistochemistry. Among 103 cases of adenocarcinoma, 38 cases (36.9%) showed positive staining in the cytoplasm of the carcinoma cells for ANGPTL4. Histologically, papillary and mucinous adenocarcinomas showed relatively high expression of ANGPTL4 (60 and 60%, respectively). The expression of ANGPTL4 was correlated with the depth of tumour invasion (p<0.005), lymph node metastasis (p<0.001), venous invasion (p<0.00005) and TNM stage (p<0.001) in the total carcinoma. In univariate survival analysis, ANGPTL4 expression was not associated with the overall survival. RT-PCR or Western blot analysis showed the expression of mRNA or protein of ANGPTL4 in all four surgically-resected samples and all four cell lines of human gastric adenocarcinoma. ANGPTL4 expression was correlated with several clinicopathological factors, especially venous invasion. These findings suggest that the ANGPTL4 is one of the factors involved in the progression of human gastric cancer. IntroductionGastric cancer is one of the most common cancer types in the world today, in spite of the fact that its incidence has shown a gradual decline in many countries (1). The occurrence and progression of cancer are considered to be a series of genetic events affecting the structure and/or expression of a number of oncogenes, tumour suppressors and growth factors (2,3). The deep invasive carcinomas, such as gastric cancer, have higher rates of lymph duct and venous invasions and lymph node metastasis (4). However, the mechanisms of invasion and metastasis of gastric carcinoma are not fully understood.The molecular mechanisms in tumour progression, local invasion and the formation of tumour metastases represent a major challenge in cancer research. Metastasis of tumour cells is the primary cause of death in patients with cancer (5). To metastasize, tumour cells undergo a multistep progression through a series of sequential and selective events (6). The metastatic process consists of tumour cell detachment, local invasion, motility, angiogenesis, vessel invasion, survival in the circulation, adhesion to endothelial cells, extravasation and regrowth in different organs (7). In each step, causative molecules have been identified; these include cell-adhesion molecules, various growth factors, matrix degradation enzymes and motility factors, of which most of these can be regarded as prognostic factors (7).There is strong evidence that the angiopoietin family is involved in the regulation of tumour progression, cellular growth and differentiation (8-10). A...

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Angiopoietins in malignancy

Cited by 78 publications

References 49 publications

Relationship between human tumour angiogenic profile and combretastatin-induced vascular shutdown: an exploratory study

Relationship between human tumour angiogenic profile and combretastatin-induced vascular shutdown: an exploratory study

Expression of angiopoietin-like 4 (ANGPTL4) in human colorectal cancer: ANGPTL4 promotes venous invasion and distant metastasis

Expression of angiopoietin-like 4 in human gastric cancer: ANGPTL4 promotes venous invasion

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