Angioregulatory microRNAs in breast cancer: Molecular mechanistic basis and implications for therapeutic strategies

Soheilifar, Mohammad Hasan; Masoudi-Khoram, Nastaran; Madadi, Soheil; Nobari, Sima; Maadi, Hamid; Neghab, Hoda Keshmiri; Amini, Razieh; Pishnamazi, Mahboubeh

doi:10.1016/j.jare.2021.06.019

Cited by 19 publications

(13 citation statements)

References 258 publications

(227 reference statements)

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“…miRNAs are key players in the epigenetic orchestration of angiogenesis, a process by which new blood vessels are formed to supply oxygen and nutrients inside tumors. The angiogenic process is regulated by a balance between pro- and anti-angiogenic stimuli involved in the degradation of the vascular basement membrane and remodeling of ECM, in endothelial cell migration and proliferation, and in generation of new matrix components [ 12 ]. Moreover, the angiogenic switch and the tumor neovascularization may be due to hypoxic conditions or the consequence of therapies promoting tumor progression [ 12 ].…”

Section: Roles Of Mir-29b In Breast Cancermentioning

confidence: 99%

“…The angiogenic process is regulated by a balance between pro- and anti-angiogenic stimuli involved in the degradation of the vascular basement membrane and remodeling of ECM, in endothelial cell migration and proliferation, and in generation of new matrix components [ 12 ]. Moreover, the angiogenic switch and the tumor neovascularization may be due to hypoxic conditions or the consequence of therapies promoting tumor progression [ 12 ]. Various studies have demonstrated the key participation of MMPs along with EMT to promote angiogenesis, infiltration by cancer cells, and metastasis [ 79 ].…”

Section: Roles Of Mir-29b In Breast Cancermentioning

confidence: 99%

“…As their targets include oncogenes and/or tumor suppressor genes, miRNAs can function as tumor promoters or suppressors, and, due to their tissue- and disease-specific expression, they are often ideal candidates as tumor biomarkers [ 11 ]. Furthermore, miRNAs may confer specific features to tumors, including resistance to radiation and chemotherapy, cancer stem cell (CSC) maintenance as well as augmented angiogenesis [ 12 ], therefore constituting prognostic markers and/or therapeutic targets [ 11 , 13 ].…”

Section: Introductionmentioning

confidence: 99%

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Mir-29b in Breast Cancer: A Promising Target for Therapeutic Approaches

2022

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The miR-29 family comprises miR-29a, miR-29b, and miR-29c, and these molecules play crucial and partially overlapped functions in solid tumors, in which the different isoforms are variously de-regulated and mainly correlated with tumor suppression. miR-29b is the most expressed family member in cancer, in which it is involved in regulating gene expression at both transcriptional and post-transcriptional levels. This review focuses on the role of miR-29b in breast cancer, in which it plays a controversial role as tumor suppressor or onco-miRNA. Here we have highlighted the dual effect of miR-29b on breast tumor features, which depend on the prevailing function of this miRNA, on the mature miR-29b evaluated, and on the breast tumor characteristics. Remarkably, the analyzed miR-29b form emerged as a crucial element in the results obtained by various research groups, as the most abundant miR-29b-3p and the less expressed miR-29b1-5p seem to play distinct roles in breast tumors with different phenotypes. Of particular interest are the data showing that miR-29b1-5p counteracts cell proliferation and migration and reduces stemness in breast tumor cells with a triple negative phenotype. Even if further studies are required to define exactly the role of each miR-29b, our review highlights its possible implication in phenotype-specific management of breast tumors.

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Section: Roles Of Mir-29b In Breast Cancermentioning

confidence: 99%

Section: Roles Of Mir-29b In Breast Cancermentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Mir-29b in Breast Cancer: A Promising Target for Therapeutic Approaches

2022

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“…The miR-467 was found to be a specific inhibitor of TSP-1, which was reported to be elevated in the BC cells after glucose stimulation ( Soheilifar et al, 2021 ). It was demonstrated that the miR-467 mimic increased the number of BC cells in the matrigel plugs in mice, indicating the proangiogenic activity of miR-467 in vivo .…”

Section: Key Micrornas In Breast Cancer Angiogenesismentioning

confidence: 99%

MicroRNAs: Important Players in Breast Cancer Angiogenesis and Therapeutic Targets

Hussen

Abdullah

Rasul

et al. 2021

Front. Mol. Biosci.

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The high incidence of breast cancer (BC) is linked to metastasis, facilitated by tumor angiogenesis. MicroRNAs (miRNAs or miRs) are small non-coding RNA molecules that have an essential role in gene expression and are significantly linked to the tumor development and angiogenesis process in different types of cancer, including BC. There’s increasing evidence showed that various miRNAs play a significant role in disease processes; specifically, they are observed and over-expressed in a wide range of diseases linked to the angiogenesis process. However, more studies are required to reach the best findings and identify the link among miRNA expression, angiogenic pathways, and immune response-related genes to find new therapeutic targets. Here, we summarized the recent updates on miRNA signatures and their cellular targets in the development of breast tumor angiogenetic and discussed the strategies associated with miRNA-based therapeutic targets as anti-angiogenic response.

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“…Most therapeutic approaches in cancer treatment are associated with toxicity, side effects, lack of selectivity, high cost, and chemoresistance. Therefore, alternative treatment agents are important and the use of herbal components becomes an important option for CRC treatment [ 28 ]. 5-FU is commonly used as an effective drug to treat many types of cancers including breast, anal, stomach, head, and neck cancer.…”

Section: Introductionmentioning

confidence: 99%

The Combination of Zerumbone with 5-Fluorouracil for Sensitizing Colorectal Cancer-Associated Fibroblasts to Treatment

Nobari

Najafi

Mahdavinezhad

et al. 2022

Evidence-Based Complementary and Alternative Medicine

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The present study aimed to evaluate the synergic effects of combination therapy on 5-fluorouracil (5-FU) resistance-cancer-associated fibroblasts (CAFs) to treatment. Chemotherapy resistance is an important challenge in colorectal cancer (CRC) eradication attention to the tumor microenvironment (TME) is very important. CAFs in the TME play an essential role in cancer chemoresistance and relapse. Additionally, many patients with advanced CRC show resistance to 5-FU therapy. Anti-tumorigenic activities of ZER, a chemopreventive compound derived from the rhizomes of the wild ginger, have been demonstrated. Synergistic and potentiating effects of combination therapy, using herbal and chemical drugs, can improve patients’ response. At the first, CAFs were isolated from a CRC patient and sorted by fluorescent-activated cell sorting (FACS), then, confirmed by flow cytometry, and immunocytochemistry (ICC). The effect of 5-FU and ZER on the cell viability was investigated by MTT assay in a dose and time-dependent manner, after that, the expression of vimentin, β-catenin, and survivin was quantified. Apoptosis, cell cycle, and invasion were analyzed by flow cytometry and scratch test, respectively. ZER could significantly sensitize CAFs cells to 5-FU. A combination of 5-FU + ZER revealed a marked decrease in the marker of interest in both mRNA and protein levels compared to control groups, including 5-FU, ZER treated, and untreated cells. Functional evaluation of cells in different groups presented significant suppression in migration of CAFs and an apparent increase in cell arrest and apoptosis by 5-FU + ZER treatment.

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Angioregulatory microRNAs in breast cancer: Molecular mechanistic basis and implications for therapeutic strategies

Cited by 19 publications

References 258 publications

Mir-29b in Breast Cancer: A Promising Target for Therapeutic Approaches

Mir-29b in Breast Cancer: A Promising Target for Therapeutic Approaches

MicroRNAs: Important Players in Breast Cancer Angiogenesis and Therapeutic Targets

The Combination of Zerumbone with 5-Fluorouracil for Sensitizing Colorectal Cancer-Associated Fibroblasts to Treatment

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