Angiosarcoma after breast‐conserving therapy

Monroe, Alan T.; Feigenberg, Steven J.; Mendenhall, Nancy P.

doi:10.1002/cncr.11277

Cited by 208 publications

(251 citation statements)

References 74 publications

Supporting

Mentioning

227

Contrasting

Unclassified

Order By: Relevance

“…In addition to RT, lymphedema has been implicated as a potential causative factor in the development of angiosarcoma. 32 Lagrange et al reported that most RIS was high grade, as observed in our study, in which 66% were grade 3. 33 Regarding RIS site, the proportion of sarcomas that arose from the maxillary sinus in the current study cohort (18.9%) was consistent with the data reported by Wang et al 17 RIS traditionally has been viewed as an aggressive tumor with a generally poor prognosis.…”

Section: Radiation-induced Sarcoma In Npc/xi Et Alsupporting

confidence: 78%

Radiation‐induced sarcoma in patients with nasopharyngeal carcinoma

Liu

Wang

et al. 2010

Cancer

View full text Add to dashboard Cite

BACKGROUND:The increasing incidence of radiation-induced sarcoma (RIS) has become a significant problem that can limit long-term survival. The objective of the current study was to analyze the clinicopathologic characteristics, treatment outcomes, and prognostic factors of RIS after radiotherapy for nasopharyngeal carcinoma (NPC). METH-ODS: Institutional electronic medical records of patients with NPC who received definitive radiotherapy between February 1964 and 2003 were reviewed. Fifty-three patients who developed RIS and fulfilled the study criteria were included. RESULTS: The median follow-up after a diagnosis of RIS was 15.5 months (range, 0.4-90.3 months), and the median latency between radiotherapy for NPC and an RIS diagnosis was 9.3 years (range, 3.2-26.6 years). Fibrosarcoma was the most frequent histologic type observed, followed by osteosarcoma, and malignant fibrous histiocytoma. The 3-year overall survival (OS) rate for 49 patients who received treatment was 32.4%, and the median survival was 21.2 months (95% confidence interval, 8.7-33.8 months). The median OS was 41.3 months, 8.4 months, and 11 months for the complete resection group, the incomplete resection group, and the chemotherapy group, respectively (P<.0001). The only independent predictive factor that was associated with better OS was complete surgical resection. CONCLUSIONS: This retrospective study confirmed the rarity and poor prognosis of RIS in patients with NPC. Complete surgical resection was a significant prognostic factor for survival. The authors concluded that long-term follow-up is necessary for the early detection of RIS in patients with NPC. Cancer 2010;116:5479-86.

show abstract

Section: Radiation-induced Sarcoma In Npc/xi Et Alsupporting

confidence: 78%

Radiation‐induced sarcoma in patients with nasopharyngeal carcinoma

Liu

Wang

et al. 2010

Cancer

View full text Add to dashboard Cite

show abstract

“…Reviewed in detail by Monroe and colleagues [68], angiosarcomas of the breast following lumpectomy and radiation therapy for breast cancer are rare but are being reported with increasing infrequency. These secondary angiosarcomas are to be distinguished from primary breast angiosarcomas, which occur in relatively younger women and which have no well-defined risk factors.…”

Section: Angiosarcoma Related To Breast-conservation Therapymentioning

confidence: 99%

Complications in Breast Surgery

Vitug

Newman

2007

Surgical Clinics of North America

154

View full text Add to dashboard Cite

The breast is a relatively clean organ comprised of skin, fatty tissue, and mammary glandular elements that have no direct connection to any major body cavity or visceral structures. In the absence of concurrent major reconstruction, breast surgery generally is not accompanied by large-scale fluid shifts, infectious complications, or hemorrhage. Thus, most breast operations are categorized as low-morbidity procedures. Because the breast is the site of the most common cancer afflicting American women, however, a variety of complications can occur in association with diagnostic and multidisciplinary management procedures. Some of these complications are related to the breast itself, and others are associated with axillary staging procedures. This article first addresses some general, nonspecific complications (wound infections, seroma formation, hematoma). It then discusses complications that are specific to particular breast-related procedures: lumpectomy (including both diagnostic open biopsy and breast-conservation therapy for cancer), mastectomy; axillary lymph node dissection (ALND), lymphatic mapping/sentinel lymph node biopsy, and reconstruction. Complications related to reconstruction are discussed in a separate article in this issue. General wound complications related to breast and axillary surgeryBecause it is a peripheral soft tissue organ, many wound complications related to breast procedures are relatively minor and frequently are managed on an outpatient basis. It therefore is difficult to establish accurate incidence rates for these events. As discussed later, however, reported studies

show abstract

“…The result was no evidence of recurrent disease after 18 months, 38 months, and 39 months (Table 5). 33,39 Combining our series of 16 patients (Tables 3 and 4) with 19 patients identified in the literature (Table 5) yielded the following results of reirradiation with or without hyperthermia. Response to treatment was reported for 23 patients.…”

Section: Discussionmentioning

confidence: 97%

“…7,17,31,32 A review of all 92 patients of angiosarcoma after breast-conserving therapy reported in the English literature revealed that 55 of 75 patients (73%) with at least 1 year of follow-up developed a local recurrence after mastectomy (n ¼ 72) or wide local excision (n ¼ 3). 33 In that review, all patients who received adjuvant radiotherapy (n ¼ 1) and/or chemotherapy (n ¼ 3) experienced a local recurrence. Most recurrences (84%) developed within 1 year after surgery.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Reirradiation and hyperthermia for radiation‐associated sarcoma

Jong

Oldenborg

Oei

et al. 2011

Cancer

View full text Add to dashboard Cite

BACKGROUND:The objective of this study was to evaluate the role of reirradiation and hyperthermia in the treatment of radiation-associated sarcoma (RAS) in the thoracic region, which is an increasing, yet extremely rare condition with a poor prognosis. METHODS: Between 1979 and 2009, 16 patients with RAS in the thoracic region were treated in the Academic Medical Center and the Institute Verbeeten with reirradiation and hyperthermia. In 13 patients, this treatment was given for unresectable disease and 3 times after resection as adjuvant treatment. The median latency period between the original malignancy diagnosis and the RAS diagnosis was 86 months (range 19-212 months). Histology was angiosarcoma in 11 patients (69%). The literature on reirradiation with or without hyperthermia for RAS was reviewed. RESULTS: The median survival was 15.5 months (range, 3-204 months). Four patients were not evaluable for response. The response rate for the remaining 12 patients was 75% (7 complete responses and 2 partial responses). Six patients remained free of local failure until death (5 months and 7 months) or last follow-up (8 months, 11 months, 39 months, and 68 months). CONCLUSIONS: The current study indicates that combined reirradiation and hyperthermia for RAS in the thoracic region is feasible. The high response rate and the possibility of durable local control suggest that this treatment is promising. Cancer 2012;118:180-

show abstract

Angiosarcoma after breast‐conserving therapy

Cited by 208 publications

References 74 publications

Radiation‐induced sarcoma in patients with nasopharyngeal carcinoma

Radiation‐induced sarcoma in patients with nasopharyngeal carcinoma

Complications in Breast Surgery

Reirradiation and hyperthermia for radiation‐associated sarcoma

Contact Info

Product

Resources

About