Angiosarcoma of the breast: A case report and literature review

Johnson, Colleen M.; Garguilo, Gerard A.

doi:10.1016/s0149-7944(02)00629-3

Cited by 22 publications

(28 citation statements)

References 20 publications

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“…Bluish skin discoloration occurs in up to a third of patients and is thought to be attributable to the vascular nature of the tumor. In the series by Yang et al [5], the mean tumor size of the mass at presentation was 5.9 cm, while in this case patient presented with a larger lump of size 17× 14×7 cm.…”

Section: Discussionmentioning

confidence: 54%

“…Surgical resection with mastectomy is the usual treatment. Since hematogenous dissemination is very common, axillary node dissection is not indicated [5,8]. It is generally recognized that breast angiosarcomas have a bad prognosis.…”

Section: Discussionmentioning

confidence: 99%

“…It is generally recognized that breast angiosarcomas have a bad prognosis. However, prognosis depends upon tumor grade (most important factor), tumor size at diagnosis, and margin status at surgery [5]. Pathologically, these tumors are subdivided into three groups according to the classification proposed by Donnel and et al [9].…”

Section: Discussionmentioning

confidence: 99%

“…However, the role of adjuvant chemotherapy is ill defined, because of the rarity of primary breast angiosarcoma and of the lack of prospective studies [5]. In most reported cases with use of chemotherapy, most authors prescribe cyclophosphamide, anthracycline, or an alkylating agent combined with a pyrimidine analogue.…”

Section: Discussionmentioning

confidence: 99%

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Primary Angiosarcoma of Breast: A Case Report

Raju

Mahajan

Rehmani

et al. 2014

Indian J Surg Oncol

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Primary breast sarcomas are rare entities. These malignant tumors originate from mesenchymal glandular breast tissue and account for <1 % of all breast cancer cases. Angiosarcomas are rare malignant tumors that arise from endothelial cells lining vascular channels. Most angiosarcomas are secondary to radiotherapy treatments for breast cancer or to an arm lymphoedema subsequent to a modified radical mastectomy. Primary angiosarcomas are rare and account for 0.04 % of all malignant breast tumors. Keywords Breast . Primary angiosarcoma Case reportA 22 year old female presented with 4 months history of awareness of painless progressive lump in left breast. There was no history of previous breast surgery or irradiation. On examination there was a large lump occupying all quadrants of left breast with skin nodules and plaques and pinkish blue discoloration (Fig. 1a). Examination of axilla was unremarkable. Trucut biopsy from the lump was suggestive of vascular channels dissecting the stroma. Vascular channels were lined by plump endothelial cells with extensive haemorrhage and focal mitotic activity. Morphology suggested possibility of angiosarcoma. Immunohistochemistry (IHC) was positive for CD 31 and CD 34. Based on these findings provisional diagnosis of angiosarcoma of left breast was kept. Chest radiograph, ultrasonography of abdomen and F-18 bone scan were negative for metastatic disease. Patient underwent total mastectomy with level I axillary lymph node dissection with latissimus dorsi myocutaneous flap reconsruction. On gross examination tumour was well circumscribed measuring 17× 14×7 cm. Histopathologic examination (HPE) showed large gaping vascular channels lined by endothelial cells, focally arranged as lobular aggregates with atypical mitosis (5-6 per 10 high power fields) and focally congested vascular channels (Fig. 1b). All margins were free of tumour. All 7 nodes resected were negative for malignancy. IHC was negative for cytokeratin and positive for CD 31 (Fig.1c) and CD 34. IHC was negative for estrogen and progesterone receptors. More than 75 % of bulk of tumour was formed by well differentiated pattern but there were significant foci showing solid areas with marked pleomorphism and mitotic activity. So, diagnosis of primary intermediate grade angiosarcoma of breast was made. Patient received 50 Gy radiation therapy to chest wall (2 Gy per fraction over 5 weeks) followed by three cycles of adriamycin and ifosfamide based chemotherapy. Following third cycle of chemotherapy she complained of bone pains. F-18 bone scan was done and it was suggestive of multiple bone metastasis while contrast enhanced computed tomogram of chest, abdomen and pelvis was negative for metastasis. DiscussionPrimary breast angiosarcoma is more frequent in young women (20 to 50 years) with no previous cancer history or other known risk factors [1,2]. Between 6 and 12 % of primary breast angiosarcomas are diagnosed during pregnancy or shortly after, suggesting hormonal involvement. However, cases reported to display ...

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Section: Discussionmentioning

confidence: 54%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Primary Angiosarcoma of Breast: A Case Report

Raju

Mahajan

Rehmani

et al. 2014

Indian J Surg Oncol

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“…It is important to differentiate the two lesions because of differences in prognosis and treatment. PASH is benign, necessitating no further intervention, whereas highly vascular angiosarcoma is a tumor that is susceptible to bleeding and it is generally managed with wide local excision and chemotherapy (6). The differentiation of the two entities is based on histology, with immunohistochemical staining for CD31 and Factor VIII.…”

Section: Discussionmentioning

confidence: 99%

Pseudoangiomatous Stromal Hyperplasia of the Breast: Mammosonography and Elastography Findings with a Histopathological Correlation

Yılmaz¹,

Güngören²,

Yılmaz³

et al. 2015

J Breasth Health

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Pseudoangiomatous stromal hyperplasia (PASH) is a rare benign mesenchymal proliferative lesion of the breast. In this study, we aimed to show a case of PASH with mammographic and sonographic features, which fulfill the criteria for benign lesions and to define its recently discovered elastography findings. A 49-year-old premenopausal female presented with breast pain in our outpatient surgery clinic. In ultrasound images, a hypoechoic solid mass located at the 3 o'clock position in the periareolar region of the right breast was observed. Due to it was not detected on earlier mammographies, the patient underwent a tru-cut biopsy, although the mass fulfilled the criteria for benign lesions on mammography, ultrasound, and elastography. Elastography is a new technique differentiating between benign and malignant lesions. It is also useful to determine whether a biopsy is necessary or follow-up is sufficient.

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Angiosarkom der Brust

Hauser

2005

Gynäkologe

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Angiosarcoma of the breast: A case report and literature review

Cited by 22 publications

References 20 publications

Primary Angiosarcoma of Breast: A Case Report

Primary Angiosarcoma of Breast: A Case Report

Pseudoangiomatous Stromal Hyperplasia of the Breast: Mammosonography and Elastography Findings with a Histopathological Correlation

Angiosarkom der Brust

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