Angiosarcoma of the Breast: A Rare and Dismal Complication of Breast Surgery Associated with Radiation

Virgilio, Edoardo; Lombardi, Mariangela; Stefano, Domenica Di; Marchetti, Paolo; Cavallini, Marco; Chieco, Paola Addario

doi:10.1177/000313481708300303

Cited by 12 publications

(30 citation statements)

References 4 publications

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“…Of all radiation‐induced sarcomas, AS corresponds to approximately 40% . AS of the breast represents <1% of all malignant mammary neoplasms . It can occur as a primary form (without a known precursor) or as a secondary form .…”

Section: Epidemiologymentioning

confidence: 99%

“…AS of the breast represents <1% of all malignant mammary neoplasms . It can occur as a primary form (without a known precursor) or as a secondary form . Primary AS represents <0.04% of all malignant breast neoplasms .…”

Section: Epidemiologymentioning

confidence: 99%

“…It can occur as a primary form (without a known precursor) or as a secondary form . Primary AS represents <0.04% of all malignant breast neoplasms . It arises in the mammary parenchyma, and it usually affects nonirradiated breasts of women in their third or fourth decades of life .…”

Section: Epidemiologymentioning

confidence: 99%

“…Primary AS represents <0.04% of all malignant breast neoplasms . It arises in the mammary parenchyma, and it usually affects nonirradiated breasts of women in their third or fourth decades of life . Secondary AS represents <0.05% of breast malignancies .…”

Section: Epidemiologymentioning

confidence: 99%

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Radiation‐induced angiosarcoma of the breast: A review

et al. 2020

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Angiosarcoma is a rare, aggressive malignant vascular neoplasm with poor prognosis that has a predilection for skin and superficial soft tissue. It can arise spontaneously or in association with factors like chronic lymphedema or radiation therapy. Radiotherapy used to treat invasive breast tumors is a known risk factor for the development of the so‐called radiation‐induced angiosarcoma (RIAS), a condition that has been described in the literature with increasing frequency. Radiation‐induced angiosarcoma of the breast usually arises on the previously irradiated skin area several years after radiotherapy and presents as painless multifocal erythematous patches or plaques similar to a hematoma. Cutaneous biopsy is essential for the diagnosis. Histologically, RIAS is characterized by irregular anastomosing vessels lined by endothelial cells showing nuclear atypia. Treatment is mostly surgical, and mastectomy with negative margins is considered the standard procedure. However, recurrences are common, and an approach combining surgery, chemo‐ and radiotherapy may be more effective. The purpose of this study is to review the most recent medical literature on RIAS of the breast, with emphasis on its pathophysiology, clinical and histological features and current treatment options.

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Section: Epidemiologymentioning

confidence: 99%

Section: Epidemiologymentioning

confidence: 99%

Section: Epidemiologymentioning

confidence: 99%

Section: Epidemiologymentioning

confidence: 99%

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Radiation‐induced angiosarcoma of the breast: A review

et al. 2020

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“…RAAS is rare with only case reports and small case series published in the literature since initially described in 1929. 6 Generally, women with RAAS are older (> 60 years) and present with a median latency period of 76 months following initial treatment. 8 Treatment of RAAS of the breast has traditionally consisted of completion mastectomy resecting all macroscopic RAAS lesions and the remaining underlying breast parenchyma.…”

Section: Introductionmentioning

confidence: 99%