Angiosarcoma of the breast associated with Kasabach-Merritt syndrome

Moussa, Sabri; Oliveira, A. L. K.; de, Amorim, Alesandro, Guedes; Scandiuzzi, Délcio; Murta, Eddie Fernando Cândido; Soares, Sheila

doi:10.1007/s004040100224

Cited by 13 publications

(13 citation statements)

References 3 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Endothelial damage also has been shown in bacterial [9,14,15] and multiple viral infections (measles virus, rubella virus, herpes simplex virus, cytomegalovirus, human immunodeficiency virus, and other viruses) [16].…”

Section: Pathophysiologymentioning

confidence: 99%

“…All these factors are known targets of nuclear factor κ-light-chain-enhancer of activated B cells (NF-κB) [3]. Clinical effectiveness of corticosteroids in management of KMS has been validated in multiple clinical trials [3,9,19,[48][49][50][51]. The initial dosing and the type of corticosteroids used in KMS vary based on the case series or case reports published.…”

Section: Corticosteroidsmentioning

confidence: 99%

“…Histologically, the tumor is composed of cavernous vascular spaces lined by a single layer of endothelium and these vascular compartments contain thin fibrous septae which may develop collagenous scar which in turn may initiate thrombosis. The term giant hemangioma usually refers to a hemangioma whose size is more than 5 cm [9]. It is not clear if there is any linear relation to the size of the hemangioma and the initiation of KMS, but most of the KMS cases are reported in giant hemangiomas.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Clinical Review: Management of Adult Kasabach-Merritt Syndrome Associated with Hemangiomas

Master¹,

Kallam²,

Eo³

et al. 2017

J Blood Disord Transfus

View full text Add to dashboard Cite

Kasabach-Merritt syndrome (KMS) consists of a clinical trial of capillary hemangioma, thrombocytopenia and disseminated intravascular coagulation. KMS occurs most commonly in the pediatric population, and its occurrence in adults is rare. Specific guidelines or randomized clinical trials guiding clinical management of KMS in adult patients are lacking. This manuscript provides a comprehensive review of KMS and discusses recent advances in the medical management of KMS. We also propose a systematic therapeutic approach which would serve as a guide in the management of adult patients with KMS caused by hemangiomas.

show abstract

Section: Pathophysiologymentioning

confidence: 99%

Section: Corticosteroidsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Clinical Review: Management of Adult Kasabach-Merritt Syndrome Associated with Hemangiomas

Master¹,

Kallam²,

Eo³

et al. 2017

J Blood Disord Transfus

View full text Add to dashboard Cite

show abstract

“…Specific to angiosarcoma, the occurrence of consumptive coagulopathy has been documented in several case reports. Two reports described bulky de novo breast angiosarcomas [8, 11], two others reported nonbulky scalp angiosarcomas in elderly Asian males [9, 10], and one case described a bulky hepatic angiosarcoma [7]. The two patients with breast disease and one with scalp disease had concomitant hemorrhage or thrombosis.…”

Section: Discussionmentioning

confidence: 99%

Consumptive Coagulopathy in Angiosarcoma: A Recurrent Phenomenon?

Farid

Ahn

Brohl

et al. 2014

Sarcoma

View full text Add to dashboard Cite

Objectives. To report the prevalence of consumptive coagulopathy in angiosarcoma patients seen at a single center. Methods. We retrospectively reviewed case records of 42 patients diagnosed with angiosarcoma at Mount Sinai Hospital between 2000 and 2013. Results. Seven patients (17%) met clinical criteria for disseminated intravascular coagulation (DIC) in absence of concomitant clinical states known to cause coagulopathy or myelosuppression. In all patients who received systemic antineoplastic therapy with resultant disease response or stability, DIC resolved in tandem with clinical improvement. DIC recurred at time of disease progression in all cases. Two patients had bulky disease, defined as diameter of largest single or contiguous tumor mass measuring 5 cm or more. All patients demonstrated an aggressive clinical course with short duration of disease control and demise within 1 year. In contrast, evaluation over the same period of 17 epithelioid hemangioendothelioma patients serving as a clinical control group revealed no evidence of DIC. Conclusion. Angiosarcomas can be associated with a consumptive coagulopathy arising in tandem with disease activity. Vigilance for this complication will be needed in the course of often aggressive multimodality therapy. The potential utility of coagulopathy as a prognostic biomarker will need to be explored in future studies.

show abstract

“…Two case reports of this very rare complication in patients with angiosarcoma of the breast have been published. 6,7 Imaging of angiosarcomas is often inconclusive. On mammogram and ultrasonogram, the mass lacks the radiological characteristics of adenocarcinoma and may be confused with benign nodules, especially in younger women.…”

Section: Presentation and Diagnosismentioning

confidence: 99%

Breast angiosarcoma that is not related to radiation exposure: A comprehensive review of the literature

et al. 2011

View full text Add to dashboard Cite

Breast angiosarcomas that are not related to previous radiotherapy are very rare. Surgical resection is the primary treatment for these tumors, but there is no general agreement on the extent of surgery. The role of multimodality adjuvant treatment also remains controversial. The aim of this study was to summarize the available data from the largest published series of patients in terms of management and outcome. We also sought to identify prognostic factors influencing patient survival. We have included studies presenting detailed data on multimodality therapy and survival of patients with breast angiosarcoma. Ten studies presenting data on 280 patients were included in the review. Seventy-five percent of patients underwent a total mastectomy and 25% had breast-conserving treatment (BCT). In 42% of patients, an axillary node dissection was combined with mastectomy or BCT. Thirty-six percent of patients received chemotherapy and 35% were treated with radiotherapy in an adjuvant or neoadjuvant setting. Survival varied significantly according to tumor size and grade. Adjuvant multimodality therapy may improve the outcome in selected patients with breast angiosarcoma. Tumor size, grade, and margin status are the most important prognostic factors for survival.

show abstract

Angiosarcoma of the breast associated with Kasabach-Merritt syndrome

Abstract: We report a 55-year-old white woman with an angiosarcoma of the left breast, anemia and thromobocytopenia due to a consumptive coagulopathy (Kasabach-Merritt syndrome).

Cited by 13 publications

References 3 publications

Clinical Review: Management of Adult Kasabach-Merritt Syndrome Associated with Hemangiomas

Clinical Review: Management of Adult Kasabach-Merritt Syndrome Associated with Hemangiomas

Consumptive Coagulopathy in Angiosarcoma: A Recurrent Phenomenon?

Breast angiosarcoma that is not related to radiation exposure: A comprehensive review of the literature

Contact Info

Product

Resources

About