Angiosarcoma of the breast

Chen, Karl T. K.; Kirkegaard, Dale D.; Bocian, J. J.

doi:10.1002/1097-0142(19800715)46:2<368::aid-cncr2820460226>3.0.co;2-e

Cited by 195 publications

(137 citation statements)

References 20 publications

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“…The average survival period is 22 months with a three-year survival rate of 38% [11]. The tumor diameter is the most important prognostic factor.…”

Section: Discussionmentioning

confidence: 99%

Angiosarcoma of the Breast with Silicone Granuloma: A Case Report

Takenaka¹,

Tanaka²,

Isobe³

et al. 2009

Kurume Med. J.

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Summary:Angiosarcoma of the breast is a rare non-epithelial tumor and that accounts for less than 0.1% of primary malignancies of the breast. The disease has a relatively higher occurrence among young people, and its prognosis (3-year-survival of only 38%) is extremely poor compared to breast cancer. Here we present a case of an 87-year-old woman who had undergone bilateral breast augmentation with silicone injections in her youth. Although she became aware of a tumor in her right breast, she waited 8 years before seeking treatment. She felt the tumor growing and experienced swelling and pain, but she ended up declining therapy at that time. Two years later she was brought to our hospital by ambulance for continuous bleeding from the same tumor of the breast, which by that time was over 11 cm in diameter. We performed emergency mastectomy. The histological diagnosis was angiosarcoma of the breast with silicone granuloma.

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“…The average survival period is 22 months with a three-year survival rate of 38% [11]. The tumor diameter is the most important prognostic factor.…”

Section: Discussionmentioning

confidence: 99%

Angiosarcoma of the Breast with Silicone Granuloma: A Case Report

Takenaka¹,

Tanaka²,

Isobe³

et al. 2009

Kurume Med. J.

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“…Sonography and magnetic resonance imaging (MRI) are useful in characterizing breast lesions, but again there are no distinctive features of angiosarcomas [6,7].…”

Section: Discussionmentioning

confidence: 97%

“…Chen et al reported a percutaneous biopsy false-negative rate of 37 % [7]. Surgical resection and microscopic examination of sufficient sample of the tumour are often necessary to render a final diagnosis.…”

Section: Discussionmentioning

confidence: 99%

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Primary Angiosarcoma of Breast: A Case Report

Raju

Mahajan

Rehmani

et al. 2014

Indian J Surg Oncol

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Primary breast sarcomas are rare entities. These malignant tumors originate from mesenchymal glandular breast tissue and account for <1 % of all breast cancer cases. Angiosarcomas are rare malignant tumors that arise from endothelial cells lining vascular channels. Most angiosarcomas are secondary to radiotherapy treatments for breast cancer or to an arm lymphoedema subsequent to a modified radical mastectomy. Primary angiosarcomas are rare and account for 0.04 % of all malignant breast tumors. Keywords Breast . Primary angiosarcoma Case reportA 22 year old female presented with 4 months history of awareness of painless progressive lump in left breast. There was no history of previous breast surgery or irradiation. On examination there was a large lump occupying all quadrants of left breast with skin nodules and plaques and pinkish blue discoloration (Fig. 1a). Examination of axilla was unremarkable. Trucut biopsy from the lump was suggestive of vascular channels dissecting the stroma. Vascular channels were lined by plump endothelial cells with extensive haemorrhage and focal mitotic activity. Morphology suggested possibility of angiosarcoma. Immunohistochemistry (IHC) was positive for CD 31 and CD 34. Based on these findings provisional diagnosis of angiosarcoma of left breast was kept. Chest radiograph, ultrasonography of abdomen and F-18 bone scan were negative for metastatic disease. Patient underwent total mastectomy with level I axillary lymph node dissection with latissimus dorsi myocutaneous flap reconsruction. On gross examination tumour was well circumscribed measuring 17× 14×7 cm. Histopathologic examination (HPE) showed large gaping vascular channels lined by endothelial cells, focally arranged as lobular aggregates with atypical mitosis (5-6 per 10 high power fields) and focally congested vascular channels (Fig. 1b). All margins were free of tumour. All 7 nodes resected were negative for malignancy. IHC was negative for cytokeratin and positive for CD 31 (Fig.1c) and CD 34. IHC was negative for estrogen and progesterone receptors. More than 75 % of bulk of tumour was formed by well differentiated pattern but there were significant foci showing solid areas with marked pleomorphism and mitotic activity. So, diagnosis of primary intermediate grade angiosarcoma of breast was made. Patient received 50 Gy radiation therapy to chest wall (2 Gy per fraction over 5 weeks) followed by three cycles of adriamycin and ifosfamide based chemotherapy. Following third cycle of chemotherapy she complained of bone pains. F-18 bone scan was done and it was suggestive of multiple bone metastasis while contrast enhanced computed tomogram of chest, abdomen and pelvis was negative for metastasis. DiscussionPrimary breast angiosarcoma is more frequent in young women (20 to 50 years) with no previous cancer history or other known risk factors [1,2]. Between 6 and 12 % of primary breast angiosarcomas are diagnosed during pregnancy or shortly after, suggesting hormonal involvement. However, cases reported to display ...

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“…The most common site of distant metastases reported by Søndenaa et al was the liver 12 , and in our group the most common site of metastasis was lungs. Primary angiosarcoma diagnosis is confirmed by core biopsy 13 as fine-needle biopsy leads to approximately 40% of false negative results 14 . Other rare histologies, such as liposarcoma, fibrosarcoma, osteosarcoma, metaplastic carcinoma, and stromal sarcoma, are excluded as part of a differential diagnosis 13 .…”

Section: Discussionmentioning

confidence: 99%

Primary Angiosarcoma of the Breast—Series of 11 Consecutive Cases—A Single-Centre Experience

et al. 2018

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Angiosarcomas of the breast are rare parenchymal malignancies of the chest wall. Surgery is the main treatment modality with chemotherapy and radiotherapy used in case of recurrence. With generally unfavourable prognosis and lack of clear treatment guidelines due to its rarity and scarcity of available data, angiosarcoma of the breast is a challenging clinical situation for both oncologist and patient. We present here the results of a series of 11 consecutive primary angiosarcoma cases treated at our institute between 2000 and 2015.

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Angiosarcoma of the breast

Cited by 195 publications

References 20 publications

Angiosarcoma of the Breast with Silicone Granuloma: A Case Report

Angiosarcoma of the Breast with Silicone Granuloma: A Case Report

Primary Angiosarcoma of Breast: A Case Report

Primary Angiosarcoma of the Breast—Series of 11 Consecutive Cases—A Single-Centre Experience

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