Angiosarcoma of the Breast with Solitary Metastasis to the Ovary during Pregnancy: An Uncommon Pattern of Metastatic Disease

Abstract

Primary de novo angiosarcoma of the breast is an uncommon, aggressive neoplasm. Here, we present a case of a young woman who initially developed primary angiosarcoma of the breast, and subsequently angiosarcoma of the ovary during pregnancy two years later. Only two confirmed primary angiosarcomas of the breast metastasizing specifically to the ovary have been described in the literature. However, all previous cases had ovarian metastases at presentation or shortly after initial diagnosis. This case is unusual as it occurred after a relatively long interval, and apparently developed during pregnancy. We discuss this rare phenomenon, as well as the possible factors contributing to the recurrence.

Bone and soft tissue sarcomas during pregnancy: A narrative review of the literature

“…Two were located to the breast and one to the skull. No data are available for the other two patients [9] , [81] , [82] , [83] .…”

Primary Breast Angiosarcoma: A Retrospective Study of 36 Cases from a Single Chinese Medical Institute with Clinicopathologic and Radiologic Correlations

“…In a rare instance, PBA may metastasize to the ovary. Including one case in this series, there were approximately five cases of PBA that metastasized to the ovary . However, lymph node metastases were relatively rare .…”

Soft tissue angiosarcoma of the breast in a patient with Klippel-Trenaunay-Weber syndrome

“…Inherited conditions including neurofibromatosis Type 1 or Li-Fraumeni syndrome and exposure to environmental compounds such as arsenic and vinyl chloride have also been related; however, most of these neoplasms develop de novo in the breast 7 . Some conditions known to predispose angiosarcoma development in other sites are KTW-S and Maffucci syndromes 8 ; nevertheless, no cases have been reported in the literature showing association between the former syndrome and angiosarcomas in the breast. KTW-S is characterized by congenital vascular malformations with a normal number of endothelial cells, contrary to blood vessel tumors in which the number of endothelial cells is increased.…”