Angiosarcoma of the Colon

Keyser, Daria; Masoumy, Mohamad; Ham, P. Benson; Biddinger, Paul; Rahardja, Andy; Legostaev, Anna; Holsten, Steven B.

doi:10.1177/000313481508100412

Cited by 5 publications

(9 citation statements)

References 4 publications

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“…Metastases at presentation occur in 38% of the cases [ 2 ]. Because of the non-specific symptoms and aggressive nature of these tumors, routine screening colonoscopies may be insufficient for timely assessment, and the diagnosis is delayed in one-fourth of the cases [ 2 , 5 ]. The sigmoid colon is the most frequently involved primary intestinal site [ 2 ].…”

Section: Discussionmentioning

confidence: 99%

“…Due to the rarity of the condition, there are no specific guidelines for the diagnosis or the management of colonic angiosarcoma [ 5 ]. Surgical resection is offered in most cases with unclear roles of chemotherapy and radiation [ 5 ]. Imatinib may be offered to patients who have CD117 positive tumors [ 2 ].…”

Section: Discussionmentioning

confidence: 99%

“…Imatinib may be offered to patients who have CD117 positive tumors [ 2 ]. Patients with angiosarcoma generally have a poor prognosis because of rapid hematogenous spread [ 5 ].…”

Section: Discussionmentioning

confidence: 99%

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Angiosarcoma of the Colon Presenting with Chronic Diarrhea, Rectal Bleeding, and Pelvic Discomfort

Jehangir¹,

Le²,

Shogbesan³

2017

Cureus

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Colonic angiosarcoma is a rare malignancy representing only 0.0012% of all colorectal malignancies. Due to its non-specific symptoms, diagnosis is often delayed. However, because of the aggressive nature of this malignancy, it is important to keep it in the differential diagnosis of rectal bleeding, pelvic discomfort, chronic diarrhea, and weight loss in patients with risk factors. We present a case of angiosarcoma of the colon in a 74-year-old female with a remote history of chemo-radiation for anal squamous cell carcinoma (ASCC).

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Angiosarcoma of the Colon Presenting with Chronic Diarrhea, Rectal Bleeding, and Pelvic Discomfort

Jehangir¹,

Le²,

Shogbesan³

2017

Cureus

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“…The relative rate of occurrence among colorectal cancers is 0.0012%, with only 24 cases reported in the literature. 1 Symptoms include abdominal pain, gastrointestinal bleeding, palpable mass, and obstructive bowel symptoms. [1][2][3][4] Risk factors for the development of the disease include chronic lymphedema, exposure to radiation, chemical carcinogens, and foreign body implants.…”

mentioning

confidence: 99%

“…Angiosarcoma cells express vimentin; endothelial markers such as CD31, CD34, and factor VIII; and are negative for epithelial markers such as cytokeratin and epithelial membrane antigen. [1][2][3][4][5] The only accepted primary treatment is surgery; the efficacy of adjuvant chemotherapy and radiation has yet to be shown.…”

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confidence: 99%

A Rare Cause of Persistent Rectal Bleeding

Primera

Matta

Mercader

2016

Clinical Gastroenterology and Hepatology

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Multiple Primary Angiosarcomas of the Colon

Radić

Zovak²,

Marić³

et al. 2021

Case Reports in Pathology

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Introduction. Gastrointestinal angiosarcomas are rare and represent less than 1% of all gastrointestinal tract malignancies, with most occurring in the stomach and small intestine. Occurrence in the colorectal segments is considered extremely rare. Case Report. We describe the case of a 61-year-old male with multiple primary angiosarcomas of the colon who presented with fever and abdominal pain. The patient was initially hospitalized and treated as having an infectious disease. A multislice computed tomography (MSCT) scan revealed multiple soft tissue tumors in the region of the left iliopsoas and gluteus medius muscles. After developing hematochezia, a colonoscopy was performed which found an ulcerated tumor in the sigmoid colon. The small tissue biopsy taken during the procedure presented diagnostic difficulties and was given a preliminary diagnosis of gastrointestinal stromal tumor (GIST). Examination of the resected colon segment and surrounding fat tissue revealed four separate tumors. Microscopically, the tumors were composed of solid sheets of spindle and epithelioid neoplastic cells with prominent nucleoli and numerous mitotic figures and immunohistochemically positive for ERG, CD31, CD34, vimentin, and CD117, while negative for CK7, CK20, CD20, CD3, CD45, TTF-1, PAN-CK, ALK, Mpox, S-100, and DOG1, leading to the final diagnosis of multiple colonic angiosarcomas. The patient’s condition declined rapidly and he passed away from multiple organ failures 60 days after initial hospitalization. Conclusion. Both clinical and pathological diagnoses of colorectal angiosarcoma are challenging. Patients are present with nonspecific symptoms leading to mismanagement and late diagnosis. A definitive pathological diagnosis relies on immunohistochemical staining for endothelial markers. Misdiagnosis as poorly differentiated adenocarcinoma or GIST is possible in limited tissue biopsies.

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Angiosarcoma of the Colon

Cited by 5 publications

References 4 publications

Angiosarcoma of the Colon Presenting with Chronic Diarrhea, Rectal Bleeding, and Pelvic Discomfort

Angiosarcoma of the Colon Presenting with Chronic Diarrhea, Rectal Bleeding, and Pelvic Discomfort

A Rare Cause of Persistent Rectal Bleeding

Multiple Primary Angiosarcomas of the Colon

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