Angiosarcoma of the lung: 2 cases report and literature reviewed

Chen, Yanbin; Guo, Linxin; Yang, Ling; Wei, Feng; Zhang, Xiuqin; Ling, Chunhua; Ji, Cheng; Huang, Jianan

doi:10.1016/j.lungcan.2010.09.002

Cited by 37 publications

(51 citation statements)

References 27 publications

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“…The primary lesion of the present patient was thought to originate from the lung according to the clinical, pathological and radiological findings; however, pulmonary lesions are typically secondary and metastatic lesions from other primary lesions in patients with angiosarcoma (Kitagawa et al 1987). Primary pulmonary angiosarcoma is rare, and there have been only 32 case reports, including the present patient, six case reports in the Japanese literature (Oka et al 1981;Sasaki et al 1992;Ogura et al 1993;Kinoshita et al 2000;Asari et al 2003;Ogawa and Takaya 2014) and 25 reported cases in the overseas literature (Ott et al 1987;Sheppard et al 1997;Keel et al 1999;Atasoy et al 2001;Junge et al 2001;Kojima et al 2003;Maglaras et al 2004;Bouhaouala et al 2005;Corpa-Rodriguez et al 2005;Pandit et al 2005;Ozcelik et al 2006;Herrak et al 2007;Wilson et al 2008;Kuroda et al 2009;Chen et al 2010;Wan Musa et al 2010;Alayon-Laguer et al 2011;Eichner et al 2011;Kakegawa et al 2012;Yang et al 2012;Obeso Carillo et al 2013;Treglia et al 2014) reported thus far. Table 1 represents the clinical characteristics of the reported 32 patients with primary pulmonary angiosarcoma.…”

Section: Discussionmentioning

confidence: 70%

Primary Pulmonary Angiosarcoma Presenting with Hemoptysis and Ground-Glass Opacity: A Case Report and Literature Review

Shimabukuro

Yatera

Noguchi

et al. 2015

Tohoku J. Exp. Med.

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Angiosarcoma originates from the vascular endothelium and accounts for only 1-2% of all sarcomatous malignancies. The skin is one of the most common primary sites. However, primary pulmonary angiosarcoma is rare, and only 31 cases of primary pulmonary angiosarcoma have been reported. A 79-year-old Japanese female developed bloody sputum, and chest X-ray and chest computed tomography (CT) showed consolidation with ground-glass opacity (GGO) on the right middle and lower lung fields. The bronchoscopic findings demonstrated bleeding from the right B 4 and B 5 , and bronchial arterial embolization was subsequently performed. However, the CT findings demonstrated new pulmonary nodules with GGO in the left lung, and she presented with hemosputum and a progression of anemia. Right hemothorax also occurred, and surgical lung resection was performed to control the bleeding. The pathological analysis of the resected lung revealed the focal growth of atypical alveolar epithelioid-like cells that were positive for CD31 and negative for epithelial membrane antigen, and these atypical cells were replacing the endothelium of the pulmonary artery. Based on these findings, the patient was diagnosed with pulmonary angiosarcoma, which might originate from the endothelium of the pulmonary artery. No abnormal findings were observed except for the pulmonary involvement on systemic CT scanning. However, the patient passed away due to respiratory failure with compression of the brainstem caused by brain metastasis three months after the first visit. Early surgical resection is the important treatment for patients with angiosarcoma. In addition, we review the literature reporting the patients with primary pulmonary angiosarcoma.

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Section: Discussionmentioning

confidence: 70%

Primary Pulmonary Angiosarcoma Presenting with Hemoptysis and Ground-Glass Opacity: A Case Report and Literature Review

Shimabukuro

Yatera

Noguchi

et al. 2015

Tohoku J. Exp. Med.

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“…Treating thyroid angiosarcoma can be challenging in many cases (6) and surgery is a commonly used option (5). Several previous studies have demonstrated that angiosarcoma is radiosensitive (6,9).…”

Section: Discussionmentioning

confidence: 99%

“…There have been fewer than 50 cases of thyroid angiosarcoma published in English. However, angiosarcoma with a tracheal origin is even rarer, with fewer than 10 cases published in English (5,18). Thus, by reviewing the prevalence of the disease and analyzing the proportion of the mass located within the thyroid confirmed that the angiosarcoma originated from the thyroid.…”

Section: Discussionmentioning

confidence: 99%

Primary Thyroid Angiosarcoma with Tracheal Invasion

et al. 2016

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A 48-year-old woman was referred to our clinic because she had been experiencing hemoptysis for 1 month. Chest computed tomography revealed a small portion of a thyroid mass was penetrating the trachea. Bronchoscopy revealed a blood vessel covered mass located in her trachea. The presence of a malignant tumor was confirmed by a biopsy. The patient was referred to the otolaryngology department for tumor resection and a pathological evaluation identified the thyroid angiosarcoma with tracheal invasion. Angiosarcomas have a poor prognosis, but the patient has not experienced any recurrence two years after surgery. A very rare case of primary thyroid angiosarcoma with tracheal invasion was cured successfully.

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“…Angiosarcoma (AS) is a malignant tumour of vascular endothelial origin contributing with only one percent of all sarcomas. [1][2][3][4][5] The presence of AS in the lung is usually a consequence of metastasis from another primary site. [1][2][3][4][5][6][7][8] The most common primary sites for AS are the skin (60%), soft tissue (25%) and in the visceral organs predominantly the heart, liver and spleen.…”

Section: Discussionmentioning

confidence: 99%