Angiosarcoma of the oral cavity: a clinicopathological study and a review of the literature

Nagata, Masashi; Yamada, Yoshitake; Nakayama, Hideki; Yoshida, Ryoji; Kawahara, Katsunobu; Nakagawa, Yoshihiro; Shinohara, Masanori

doi:10.1016/j.ijom.2014.02.008

Cited by 32 publications

(62 citation statements)

References 24 publications

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“…8 There have been only 35 reports of primary oral angiosarcoma in the English literature over the past 20 years. 9 We report an unusual case of primary angiosarcoma of the maxillary gingiva submucosa that clinically resembled a reactive lesion of the gingiva.…”

Section: Discussionmentioning

confidence: 96%

“…6 One hallmark of poorly differentiated angiosarcoma is fragmented erythrocytes within intracytoplasmic vacuoles. 9,10 Epithelioid angiosarcoma (EA) is a rare and highly aggressive variant that has an epithelial morphology and cytokeratin positive immunohistochemistry; thus making it difficult to distinguish from a poorly differentiated carcinoma. 7,11 …”

Section: Discussionmentioning

confidence: 99%

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Red exophytic mass of the maxillary anterior gingiva

Aljadeff

Fisher

Wolf

et al. 2016

Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology

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CASE REPORT79-year-old male presented to his general dentist with a red and ulcerated exophytic growth between his maxillary left lateral incisor and canine ( Figure 1A). The patient denied any paresthesia or pain associated with the lesion and had no evidence of cervical lymphadenopathy. He denied fever, chills, nausea, vomiting, diarrhea, constipation, or recent weight change. The patient reported a history of smoking a pack of cigarettes a day for approximately 30 years but reported quitting about 25 years ago. He did not report any

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Section: Discussionmentioning

confidence: 96%

Section: Discussionmentioning

confidence: 99%

Red exophytic mass of the maxillary anterior gingiva

Aljadeff

Fisher

Wolf

et al. 2016

Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology

View full text Add to dashboard Cite

show abstract

“…Angiosarcoma may be di cult to diagnose because of its various clinical and pathological characteristics [2]. Differential diagnoses include hemangioma, pyogenic granuloma, Kaposi's sarcoma, melanoma, and metastatic disease [13][14][19][20].…”

Section: Discussionmentioning

confidence: 99%

“…Generally, radiographic ndings for angiosarcoma may include osteolytic changes with a mild periosteal reaction [21]. Reviewing previous reports, it seems that the swelling of the gingiva accompanied by bone destruction with rapid growth of tumor (Table 2) [2,11,[13][14][15][16][17]. In these cases, although the lesion may have originated from bone tissue, a relatively well-de ned margins may simulate a benign osteolytic lesion such as a cyst or an odontogenic tumor.…”

Section: Discussionmentioning

confidence: 99%

Primary epithelioid angiosarcoma originating from the mandibular gingiva: a case report of an extremely rare oral lesion

Komatsu¹,

Miyamoto

Ohashi³

et al. 2020

Preprint

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Background Angiosarcoma occurs very rarely in the oral cavity, and the epithelioid type is even rarer. Here, we report a rare case involving an elderly man with a primary epithelioid angiosarcoma that originated from the mandibular gingiva and resembled a dentigerous cyst on radiographs. Case presentation A 66-year-old Japanese man visited our hospital with a chief complaint of gingival swelling in right mandibular third molar region. A panoramic radiograph showed bone resorption around the crown of right mandibular third molar, which was impacted. Incisional biopsy confirmed a diagnosis of epithelioid angiosarcoma. The lesion exhibited aggressive proliferation after biopsy resulting in uncontrolled bleeding and difficulty in closing the mouth. Mandibular segmental resection including the tumor was performed without reconstruction. Because of the aggressive preoperative course of the tumor, the patient received adjuvant chemotherapy. There were no signs of recurrence during a 2-year follow-up period. ConclusionsA review of the literature yielded only four reported cases of epithelioid angiosarcoma in the jaw region, with the lesions occurring in the maxilla in three cases. To our knowledge, this is the second case of primary epithelioid angiosarcoma in the mandible.

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“…AS is a highly malignant soft tissue sarcoma originated from vascular endothelial cells, accounting for less than 1% of soft tissue sarcoma [1]. It often occurs in the skin, subcutaneous tissue of the head and face [9],breast, but also in the mouth [10], mediastinum [11], kidney [12], thyroid [13], lung and other anatomical sites [14]. AS in digestive system is rare, but in solid organs such as liver and spleen is relatively common [15].…”

Section: Discussionmentioning

confidence: 99%

Primary small intestinal epithelioid angiosarcoma: a potential diagnostic pitfall due to abnormal expression of cytokeratin

yuanyuan

Fang

Zhang

et al. 2020

Preprint

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Background: Primary small intestinal epithelioid angiosarcoma (EAS) is a very rare tumor, which originates from endothelial cell with high mortality. Only 66 cases of small intestinal angiosarcoma including primary or metastatic were reported in the current literature. Histologically, hemangiosarcoma with epithelioid cell morphology is more rare, so we report a case of EAS which is easily misdiagnosed as poorly differentiated carcinoma. We also reviewed the literature about small intestinal angiosarcoma.Case presentation: The patient was a 60-year-old man, who initially presented black stool with no obvious inducement for 7 days, gradually feeling dizzy and fatigue for 3 days. Abdominal CT showed that the intestinal wall of the upper jejunum was thickened near the duodenum. After enhancement, the intestinal wall could be enhanced evenly. With the time going on, the contrast media could be concentrated gradually, and the active hemorrhage was considered. Enteroscopy revealed a 30 mm × 20 mm red polypoid mass in the jejunum. A biopsy of polypoid mass exhibited malignant tumor, histopathology considered poorly differentiated cancer. The patient subsequently underwent resection of the jejunal neoplasm. Immunohistochemistry vascular markers and cytokeratin were postive，but C-MYC protein was negative, and showed no amplification of C-MYC gene by Fluorescence in situ hybridization （FISH）. The histopathology with immunohistochemical and FISH studies confirmed the diagnosis of primary small intestinal EAS. 24 months after surgery, the patient had no evidence of recurrence and metastasis.Conclusion: Primary small intestinal EAS is a rare malignancy of endothelial origin with uncertain etiology and often has a poor prognosis.The abnormal cytokeratin expression in epithelioid angiosarcomas represents a potential diagnostic pitfall for pathologists. FISH detection of C-MYC gene amplification may have some value in the diagnosis of primary or metastatic small intestinal AS.An accurate pathological diagnosis relies on histopathology with immunohistochemical stains of endothelial markers. Surgical resection remains the best treatment option for small intestinal angiosarcoma.

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Angiosarcoma of the oral cavity: a clinicopathological study and a review of the literature

Cited by 32 publications

References 24 publications

Red exophytic mass of the maxillary anterior gingiva

Red exophytic mass of the maxillary anterior gingiva

Primary epithelioid angiosarcoma originating from the mandibular gingiva: a case report of an extremely rare oral lesion

Primary small intestinal epithelioid angiosarcoma: a potential diagnostic pitfall due to abnormal expression of cytokeratin

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