Angiosarcoma of the thyroid and concurrent hyperthyroidism

Proces, S.; Schroeyers, Pascal; Delos, Monique; Michel, Luc; Donckier, Julian

doi:10.1007/bf03347289

Cited by 13 publications

(15 citation statements)

References 5 publications

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“…The histogenesis of these very aggressive tumors has been the matter of long standing controversies, because many authors believe that ASs are a variant of sarcomatoid carcinoma, in view of their nearly constant cytokeratin positivity in the neoplastic elements [17,19,25,26]. Other authors believe that true AS of the thyroid does exist, though it is rarely observed [2,4,8,9,14,18,21,31,33,37,39,40,41]. AS is apparently unrelated to the follicular cell lineage and develops mostly in endemic goiter areas, possibly being the result of malignant transformation of goitrous nodules that underwent recurrent intranodular hemorrhagic events with subsequent thrombotic and hyperplastic endothelial proliferations [11].…”

Section: Introductionmentioning

confidence: 95%

Thyroglobulin mRNA expression helps to distinguish anaplastic carcinoma from angiosarcoma of the thyroid

et al. 2000

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The existence of angiosarcoma (AS) of the thyroid has been a matter of debate for many years, because some authors believe that most if not all ASs are in fact "angiomatoid" anaplastic carcinomas (ACs). Immunohistochemistry alone was not successful in solving the problem, since cytokeratin expression is a known occurrence in AS. Therefore, we wanted to compare nine cases of AS with ten cases of AC, assessing whether thyroglobulin (TG) mRNA was still transcribed in undifferentiated tumors and could be helpful to distinguish AC from AS. The cases were analyzed for TG mRNA expression by means of radioactive in situ hybridization. The silver grains were counted using an automated device, and their amount was compared with that of stroma, background, and peritumoral thyroid. A weak signal was present in all AC but not in AS (mean counts 35.7 and 9.6 arbitrary units, respectively: P<0.01). In two cases of AC, residual areas of poorly differentiated insular carcinoma had a strong signal (similar to that of peritumoral thyroid). These findings further confirm that AC and AS of the thyroid are unrelated malignant tumors.

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Section: Introductionmentioning

confidence: 95%

Thyroglobulin mRNA expression helps to distinguish anaplastic carcinoma from angiosarcoma of the thyroid

et al. 2000

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“…Angiosarcoma of the thyroid in association with hyperthyroidism is a rare condition and is reported in the literature [5]. The present case had also concurrent hyperthyroidism.…”

Section: Discussionmentioning

confidence: 49%

A Case of Hemangiosarcoma in Thyroid with Severe Anemia due to Bone Marrow Metastasis

et al. 2005

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Abstract.A 56-year-old woman presented with rapidly enlarging thyroid mass and deep anemia. There was no history of gastrointestinal bleeding, and endoscopic examinations of the gastrointestinal system were normal. Fine needle aspiration cytology from the thyroid nodule was suspicious. After blood transfusion, total thyroidectomy was performed. Postoperative histopathological examination of the specimen revealed hemangiosarcoma of the thyroid. After establishment of the diagnosis chemotherapy was started. But hemoglobin values decreased again and hepatosplenomegaly developed at the second month of surgery. Bone marrow aspiration cytology which was performed demonstrated the same tumoral cells infiltrating bone marrow. The patient died at 12th week after surgery. Thyroid hemangiosarcoma can metastasize to the bone marrow and anemia may be an indicator of the advanced disease. In the differential diagnosis of the anemia, bone marrow metastasis and bone marrow biopsy should be considered in suspected cases.

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“…Most European authors think that these lesions represent true vascular neoplasms. 6,8,9,14,15,17,20,22,23,25 Authors who accept the vascular nature of these specimens base their assertion on the factor VIII immunoreactivity of the neoplastic cells. 21,28,29 The vascular nature has been corroborated by several ultrastructural studies that have supported an endothelial origin.…”

Section: Discussionmentioning

confidence: 99%