Angiosarcoma of the Thyroid Gland: A Case Report

Zouaidia, Fouad

doi:10.4021/jmc2010.07.107e

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“…It is more common in females (ratio 9:3) and mainly occurs between the fifth and eighth decades (the median age of 65 years) ( 1 , 6 , 9 ). Generally, these tumors present as a painless infiltrating mass with tendency to increase its size ( 1 ), which can vary from 2.5 to 11cm, being usually unifocal ( 6 , 10 ). Cytological characteristics of this type of cancer have not been clearly defined yet and are rarely described in the literature ( 5 ).…”

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confidence: 99%

Invasive Thyroid Angiosarcoma With a Favorable Outcome

Couto

Martins

Santos

et al. 2014

Int J Endocrinol Metab

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Introduction:Thyroid angiosarcoma is a malignant neoplasm, which usually shows local aggressive behavior and associated with a high recurrence rate. It was originally described in the Alpine region and extremely rare in other parts of the world.Case Presentation:An asymptomatic 61-year-old woman presented with a right lobe thyroid nodule with fine needle aspiration cytology indicating “suspicious for malignancy” was reported in our study. Histological examination revealed a vascular 35mm neoplasm with areas of necrosis. Immunohistochemistry staining had negative results for MNF, CAM5.2, CD34, thyroglobulin, and positive for CD31. The findings described were compatible with angiosarcoma diagnosis. Besides, a 4mm papillary microcarcinoma was found in the left lobe. Computerized tomography (CT) scan performed about two months after the operation, showed a right neck nodular lesion, conditioning tracheal deviation. At our institution, the study performed was consistent with local recurrence (angiosarcoma). Tumor excision was performed and invasion to larynx, trachea and esophagus was detected intraoperatively. Histopathologic examination confirmed tumor recurrence and the patient was submitted to radiotherapy (60 Gy), completed four years ago. There is not, so far, any evidence of tumor recurrence.Conclusions:We described a rare case of a usually aggressive thyroid angiosarcoma in a patient living in a non-Alpine region, with an unusual favorable outcome after the operation and radiotherapy.

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