Angiosarcomas of the interatrial septum mimicking atrial myxomas

Rodrigues, Andressa Giestas; Tardif, Jean‐Claude; Petitclerc, Robert; Mercier, Lise‐Andrée; Paquet, E; Leung, Tack Ki; Delorme, F.

doi:10.1016/s0894-7317(96)90033-4

Cited by 6 publications

(2 citation statements)

References 9 publications

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“…These symptoms include dyspnea, hemoptysis, chest pain, and malaise (10,(13)(14). However, more localizing symptoms may also occur such as a friction rub, diminished heart sounds, tamponade (if a pericardial effusion is present) and angina, arrhythmias, and heart block (if the tumor infiltrates the myocardium; 15).…”

Section: Discussionmentioning

confidence: 99%

Extracutaneous Angiosarcomas Metastatic to the Lungs: Clinical and Pathologic Features of Twenty-One Cases

et al. 2001

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Angiosarcomas are rare malignant vascular tumors with a high rate of metastasis involving lungs (most commonly), liver, regional lymph nodes, bone, and other sites. In this study, we have reviewed the clinical presentation and histopathology of 21 cases of extracutaneous angiosarcoma metastatic to the lungs. Tumors with exclusively pleural involvement were excluded. Patients presented with dyspnea, chest pain, and/or hemoptysis lasting a few weeks to months. Radiologically, the most common finding comprised multiple peripheral lung nodules (57%), often accompanied by infiltrates. For 11 cases (52%), the primary tumor was not identified at the time of presentation. Vasoformative areas were identified in 15 cases (71%). Nine cases comprised spindle cells (43%), two contained epithelioid cells (9.5%), and 10 consisted of both spindle and epithelioid cells (48%). Nuclear pleomorphism was at least moderate in all cases. However, five tumors contained regions of minimal nuclear atypia. Hemorrhage, siderophages, and fibrosis were commonly present. Immunohistochemical staining (IHS) was performed on 14 cases. Thirteen tumors showed reactivity for vascular markers. Tumor cells reacted for Von Willebrand factor in 13 of 14 cases, and CD31 and CD34 were each positive in 2/2 cases. Two cases (of nine examined) also expressed cytokeratins. Because the tumor often first presented in the lungs before the primary sarcoma was identified, the clinical impression included both benign and malignant entities. For patients with primary cardiac tumors, symptoms referable to the primary tumor complicated the clinical presentation, and radiologic evaluation supported a clinical diagnostic impression of non-neoplastic pericarditis. Thus, angiosarcoma in the lung may elude diagnosis until histopathologic evaluation of the lung biopsy.

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Section: Discussionmentioning

confidence: 99%

Extracutaneous Angiosarcomas Metastatic to the Lungs: Clinical and Pathologic Features of Twenty-One Cases

et al. 2001

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“…As highlighted by the present case, benign and malignant tumours can have overlapping features. Angiosarcoma originating from the interatrial septum has been reported previously in the echocardiographic literature [22], but as far as we are aware, this is the first such case depicted with CMR.…”

Section: Discussionmentioning

confidence: 73%

Primary cardiac angiosarcoma arising from the interatrial septum: magnetic resonance imaging appearances

Puppala

Hoey²,

Mankad³

et al. 2010

BJR

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We present a case of primary cardiac angiosarcoma arising from the interatrial septum that had imaging features overlapping with those of right atrial myxoma. The mass was initially discovered on a thoracic CT study. Further evaluation with echocardiography was limited by poor acoustic windows and cardiac magnetic resonance (CMR) imaging was performed prior to surgical resection. CMR provided a detailed morphological assessment; imaging features included a frond-like surface architecture, a narrow attachment point at the interatrial septum, mild signal hyperintensity compared with that of myocardium on T(1) weighted sequences, patchy foci of delayed gadolinium enhancement and a haemorrhagic pericardial effusion. To the best of our knowledge, this is the first reported case of angiosarcoma arising from the interatrial septum that has undergone evaluation with CMR.

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CMR Assessment of Cardiac Masses

Aghayev

Steigner

2019

Contemporary Cardiology

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Angiosarcomas of the interatrial septum mimicking atrial myxomas

Cited by 6 publications

References 9 publications

Extracutaneous Angiosarcomas Metastatic to the Lungs: Clinical and Pathologic Features of Twenty-One Cases

Extracutaneous Angiosarcomas Metastatic to the Lungs: Clinical and Pathologic Features of Twenty-One Cases

Primary cardiac angiosarcoma arising from the interatrial septum: magnetic resonance imaging appearances

CMR Assessment of Cardiac Masses

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