2022
DOI: 10.3390/membranes12020108
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Angiostrongylus cantonensis an Atypical Presenilin: Epitope Mapping, Characterization, and Development of an ELISA Peptide Assay for Specific Diagnostic of Angiostrongyliasis

Abstract: Background: Angiostrongyliasis, the leading cause universal of eosinophilic meningitis, is an emergent disease due to Angiostrongylus cantonensis (rat lungworm) larvae, transmitted accidentally to humans. The diagnosis of human angiostrongyliasis is based on epidemiologic characteristics, clinical symptoms, medical history, and laboratory findings, particularly hypereosinophilia in blood and cerebrospinal fluid. Thus, the diagnosis is difficult and often confused with those produced by other parasitic diseases… Show more

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“…Although much is known about the involvement of presenilins with signal transduction in humans, very little is known in unicellular organisms and parasites. Recently, the PS-like protein [24] and some components of the GSC [25] was characterized in Trypanosoma cruzi and other parasites [26] by our group. During our characterization studies of this group of membrane protein in Leishmania sp, we did not identify any protein with significant similarity to Pen-2.…”
Section: Introductionmentioning
confidence: 99%
“…Although much is known about the involvement of presenilins with signal transduction in humans, very little is known in unicellular organisms and parasites. Recently, the PS-like protein [24] and some components of the GSC [25] was characterized in Trypanosoma cruzi and other parasites [26] by our group. During our characterization studies of this group of membrane protein in Leishmania sp, we did not identify any protein with significant similarity to Pen-2.…”
Section: Introductionmentioning
confidence: 99%