Angiotensin-(1-7), Adipokines and Inflammation

Lelis, Deborah de Farias; Freitas, Daniela Fernanda de; Machado, Amanda Souto; Crespo, Thaísa Soares; Santos, Sérgio Henrique Sousa

doi:10.1016/j.metabol.2019.03.006

Cited by 94 publications

(69 citation statements)

References 153 publications

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“…Angiotensin (AT) II promotes prostacyclin synthesis, differentiation of the adipocytes and lipogenesis. Inside the adipose cell, ACE is stimulated towards the conversion of angiotensin I to angiotensin II, thus further stimulating the RAAS axis, the production of aldosterone and the rise in blood pressure [20]. Various reports have included arterial hypertension as a risk factor for severity of SARS-CoV-2, possibly related to ACE2 via the actions of ACE-inhibitors and AT receptor blockers (ARB), given for the treatment of hypertension (ACE2 acts as receptor that indeed seems to facilitate the entry of coronavirus into cells) [21].…”

Section: Molecular Pathwaysmentioning

confidence: 99%

SARS-CoV-2 infection and obesity: Common inflammatory and metabolic aspects

Michalakis¹,

Ilias²

2020

Diabetes & Metabolic Syndrome: Clinical Research & Revi

145

122

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Backround and aims: According to the World Obesity Federation, "obesity-related conditions seem to worsen the effect of Covid-19 (SARS-CoV-2)"; additionally the Centres for Disease Control and Prevention reported that "people with heart disease and diabetes are at higher risk of SARS-CoV-2 complications and that severe obesity poses a higher risk for severe illness". Recent reports have shown elevated levels of cytokines due to increased inflammation in patients with SARS-CoV-2 disease. On the other hand, obesity represents a state of low-grade inflammation, with various inflammatory products directly excreted by adipose tissue. In this concise report we aimed to assess common elements of obesity and SARS-CoV-2 infection. Methods: Pubmed search on obesity and SARS-CoV-2 infection. Results: We present "mechanistic" obesity-related problems that aggravate SARS-CoV-2 infection as well as tentative inflammatory/metabolic links between these diseases. Conclusion: Obesity and SARS-CoV-2 share common elements of the inflammatory process (and possibly also metabolic disturbances), exacerbating SARS-CoV-2 infection in the obese.

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Section: Molecular Pathwaysmentioning

confidence: 99%

SARS-CoV-2 infection and obesity: Common inflammatory and metabolic aspects

Michalakis¹,

Ilias²

2020

Diabetes & Metabolic Syndrome: Clinical Research & Revi

145

122

View full text Add to dashboard Cite

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“…Adipose tissue secretes hormone-like substances, known as adipokines. Adipokines are cytokines, secreted by adipose tissue, which have paracrine and endocrine actions and regulate metabolism, inflammation, and body homeostasis [64]. Through adipokines, the adipose tissue influences the appetite, satiety, energy expenditure, fat storage, and insulin secretion and sensitivity [65].…”

Section: Potential Mechanismsmentioning

confidence: 99%

Duration of Lactation and Maternal Risk of Metabolic Syndrome: A Systematic Review and Meta-Analysis

Tørris

Bjørnnes

2020

Nutrients

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Cardiovascular disease (CVD) is the leading cause of death of women across all ages, and targeting modifiable risk factors, such as those comprised in metabolic syndrome (MetS) (e.g., waist circumference, lipid profile, blood pressure, and blood glucose), is of great importance. An inverse association between lactation and CVD has been suggested, and lactation may decrease the risk of MetS. This systematic review and meta-analysis examined how lactation may affect the development and prevalence of MetS in women. A literature search was performed using Cinahl, Embase, Web of Science, and PubMed. A total of 1286 citations were identified, and finally, ten studies (two prospective and eight cross-sectional) were included. Seven studies (two prospective and five cross-sectional) revealed associations between lactation and MetS, suggesting that breastfeeding might prevent or improve metabolic health and have a protective role in MetS prevention. This protective role might be related to the duration of lactation; however, a lack of controlling for potential confounders, such as parity, might inflict the results. The pooled effect was non-conclusive. Additional research is required to further explore the duration of lactation and its potential role in improving or reversing MetS and its components.

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“…ACE2 converts angiotensin II into angiotensin 1-7. ACE inhibitors (ACEIs) inhibit the formation of angiotensin II from angiotensin I, followed by conversion of angiotensin I to angiotensin 1-9 which ultimately is transformed to angiotensin 1-7 by ACE2 [35][36][37][38]. By binding to the angiotensin receptor themselves, Angiotensin receptor antagonists (ARBs) impede the effect of angiotensin II.…”

Section: The Perplexity Regarding Ace2mentioning

confidence: 99%

COVID-19 and diabetes; Possible role of polymorphism and rise of telemedicine

Sayed

2021

Primary Care Diabetes

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Background: Diabetes has been found to be one of the leading comorbidities associated with fatality in COVID-19 patients. Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) entry is facilitated by interaction with Angiotensin Converting Enzyme-2 (ACE2) and possible polymorphisms in ACE2 can be a determining factor in host-viral protein interaction. A significant shift of healthcare towards 'Telemedicine' is also on the rise. In this review, the possible effects of ACE2 polymorphisms on SARS-CoV-2 entry along with the escalation of 'telemedicine' is discussed. Method: An expansive literature search using keywords: "COVID-19", "SARS-CoV-2", "diabetes", "type 2 diabetes", "type 1 diabetes", "ACE2", "polymorphism", "DPP4" and "telemedicine" was conducted on Pubmed and EMBASE till 7th August 2020. Result: Possible polymorphisms in ACE2 gene can play a role in influencing the virus entry in host body. Telemedicine can bring a new revolution for medical sector. Conclusion: COVID-19 severity is more heinous among diabetic population. So far, the in-silico studies involving human ACE2-viral Spike (S) interaction showed inconsistent predictions regarding some SNPs. But without actual in-vivo studies, a holistic understanding can't be established.

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Angiotensin-(1-7), Adipokines and Inflammation

Cited by 94 publications

References 153 publications

SARS-CoV-2 infection and obesity: Common inflammatory and metabolic aspects

SARS-CoV-2 infection and obesity: Common inflammatory and metabolic aspects

Duration of Lactation and Maternal Risk of Metabolic Syndrome: A Systematic Review and Meta-Analysis

COVID-19 and diabetes; Possible role of polymorphism and rise of telemedicine

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