Angiotensin (1–7) and Apelin co-therapy: New strategy for heart failure treatment of rats

Hekmat, Ava Soltani; Javanmardi, Kazem; Tavassoli, Alireza; Gholampour, Yousof

doi:10.14744/anatoljcardiol.2019.40072

Cited by 2 publications

(1 citation statement)

References 33 publications

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“…The slides in each category were microscopically analyzed using an Olympus BX-53 microscope, and all histopathological changes (e.g., inflammatory cell infiltration, hemorrhaging, and necrosis of myofibers) were examined. 23 The severity of these pathological lesions was ranked as follows: score 0 was considered to be normal; score 1 as borderline; score 2 as mild; score 3 as moderate and score 4 as severe.…”

Section: Histological Examination Of the Myocardiummentioning

confidence: 99%

Alamandine significantly reduces doxorubicin-induced cardiotoxicity in rats

et al. 2021

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Doxorubicin (DOX) is an anthracycline antibiotic. Despite its unwanted side effects, it has been successfully used in tumor therapy. Given that oxidative stress and inflammatory factors are essential to cardiotoxicity caused by DOX, we assumed that alamandine, which enhances endogenous antioxidants and has anti-inflammatory effects, may prevent DOX-induced cardiotoxicity. Rats received DOX (3.75 mg/kg) i.p on days 14, 21, 28, and 35 (total cumulative dose = 15 mg/kg) and alamandine (50 μg/kg/day) via mini-osmotic pumps for 42 days. At the end of the 42-day period, we evaluated hemodynamic parameters, electrocardiogram, cardiac troponin I (cTnI), superoxidase dismutase (SOD), total antioxidant capacity (TAC), malondialdehyde (MDA), inflammatory cytokines (tumor necrosis factor-α (TNF-α), IL-1β, NF-κB), apoptosis markers (caspase 3), and histopathology of haemotoxylin- and eosin-stained cardiac muscle fibers were evaluated. DOX significantly increased QT, corrected QT (QTc), and RR intervals. Alamandine co-therapy prevented ECG changes. Alamandine administration restored DOX-induced disruptions in the cardiac muscle architecture and vascular congestion. Alamandine co-therapy also alleviated other effects of DOX, including cardiac contractility, decreased systolic and diastolic blood pressure, and increased left ventricular end-diastolic pressure. Moreover, alamandine co-therapy substantially decreased the elevation of oxidative stress markers, inflammatory cytokines, and caspase 3 in DOX-treated rats. The results suggest that alamandine reduced DOX-induced cardiotoxicity via antioxidant, anti-inflammatory, and anti-apoptotic activities.

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Section: Histological Examination Of the Myocardiummentioning

confidence: 99%