Angiotensin-(1-7) Central Mechanisms After ICV Infusion in Hypertensive Transgenic (mRen2)27 Rats

Kangussu, Lucas M.; Melo‐Braga, Marcella Nunes; Lima, Bruna Soares de Souza; Santos, Robson Augusto Souza; Andrade, Hélida Monteiro de; Campagnole‐Santos, Maria José

doi:10.3389/fnins.2021.624249

Cited by 8 publications

(4 citation statements)

References 65 publications

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“…Lower BP during pregnancy is achieved by maintaining a balance between increased levels of Ang II and decreased sensitivity to Ang II together with higher levels of Ang-(1-7). Ang-(1-7) has a vasodilatory (RAS modulation), antithrombotic and anti-inflammatory (decreasing TNF-α levels and increasing the antiinflammatory activity of IL-10) effect [49,50].…”

Section: Cardiovascular Systemmentioning

confidence: 99%

Pregnancy as a Risk Factor of Severe COVID-19

Celewicz

Michalczyk

et al. 2021

JCM

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Since first being identified in December 2019, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) as an etiological agent behind Coronavirus disease 19 (COVID-19), has caused three waves of a global pandemic, with a fourth in progress. Despite its high percentage of asymptomatic and low-symptomatic courses of illness, the SARS-CoV-2 pandemic has claimed a higher death toll than the SARS-CoV and MERS-CoV epidemics because of its high infectivity when compared to the other coronaviruses. High COVID-19 mortality is associated with age and other coexisting morbidities, as well as healthcare quality. According to several studies, pregnant women are at a higher risk of severe COVID-19 infection and adverse pregnancy outcomes (caesarean delivery, pre-term birth, low birth weight, preeclampsia, ICU admission, and need for mechanical ventilation). In our review of recent literature, we focused on the effects of COVID-19 in pregnant women, emphasizing the subcellular pathophysiology of SARS-CoV-2. In this paper, we concentrate on the pathophysiology of sub-cellular changes in COVID-19 and endeavor to highlight the aspects that manifest in physiological pregnancy and potentially create a higher risk of SARS-CoV-2 infection and acute COVID-19 symptoms. Understanding how pregnancy-associated changes can cause a synergistic effect with COVID-19 may point us in the right direction for future prophylaxis and treatment for women undergoing COVID-19 during pregnancy.

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Section: Cardiovascular Systemmentioning

confidence: 99%

Pregnancy as a Risk Factor of Severe COVID-19

Celewicz

Michalczyk

et al. 2021

JCM

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“…Gene expression was quantified using the comparative Ct (threshold cycle) method. Primers sequence of AT1: 5 ′ -GGT GGG AAT ATT GGA AAC AG-3 ′ (forward) and 5 ′ -AAG AAG AAA AGC ACA ATC GCC-3 ′ (reverse); Mas receptor: 5 ′ -CCC ACC CAT TCC CAT AGT GC-3 ′ (forward) and 5 ′ -CCG AGA GGA GAG ATG CTC ATG-3 ′ (reverse); iNOS: 5'-CCT TGT TCA GCT ACG CCT TC-3' (forward) and 5'-GGT ATG CCC GAG TTC TTT CA-3' (reverse); endogenous control S26: 5 ′ -CGA TTC CTG ACA ACC TTG CTA TG-3 ′ (forward) and 5 ′ -CGT GCT TCC CAA GCT CTA TGT-3 ′ (reverse) (Kangussu et al, 2021).…”

Section: Measurement Of At 1 Mas Receptors and Inducible Nitric Oxid...mentioning

confidence: 99%

Transgenic rat with overproduction of ubiquitous angiotensin-(1-7) presents neuroprotection in a model of ischemia and reperfusion

Kangussu

Almeida-Santos

Fernandes

et al. 2023

Brain Research Bulletin

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“…Cardiomyocyte diameters in hematoxylin and eosin-stained sections among all groups were measured throughout the nucleus-corresponding area. Only longitudinally cut cardiomyocytes with visible nuclei and cellular boundaries were considered for the analysis (Kangussu et al, 2021). Area % of collagen fibers, NF-κB, TNFα, immunoreactions were also estimated using (ImageJ) computer software for image analysis (Wayne Rasband, NIH, Bethesda, Maryland, USA).…”

Section: Histopathologic Evaluation Of Cardiac Injurymentioning

confidence: 99%

Interleukin-37 has A Promising Cardioprotective Effect on Isoproterenol-Induced Myocardial Infarction

Elkattawy,

El-Sayed-Hassan,

Ebrahim-Alsemeh

et al. 2023

Int. J. Morphol.

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The main cause of mortality and disability globally is myocardial infarction (MI). Isoproterenol (ISO), a β-adrenoceptor agonist, has been used to induce rat myocardial necrosis. Whereas interleukin-37 (IL-37) has anti-inflammatory and cytoprotective properties. The study aimed to investigate the potential protective effects of IL-37 administration on cardiac architecture, oxidative stress, and inflammatory markers during ISO-induced MI in rats. Three groups of adult male rats were used in this study, the normal control group (n=8), ISO-induced MI group (n=8) that received isoproterenol hydrochloride (ISO) (100 mg/kg/day, SC, for the first 2 consecutive days), and IL-37-treated group (ISO+IL-37) (n=8) that received recombinant human IL-37 (40 µg/kg /day, intraperitoneally, for 2 weeks during and after ISO injections. Heart rate (HR.) and ECG changes were monitored. Some oxidative stress markers such as superoxide dismutase (SOD), nitric oxide (NOx), malondialdehyde (MDA), and glutathione (GSH) tissue levels in the tissue homogenate were assayed. Interleukin-6 (IL-6), tumor necrosis factor-α (TNF-α), caspase-8, P53, and C-reactive protein (CRP) were among the inflammatory markers examined. In addition, serum levels of creatinine kinase (CK-MB) and lactate dehydrogenase (LDH) were analyzed to evaluate the myocardial injury. For histological analysis, tissues were sectioned, fixed in paraffin, and stained with hematoxylin and eosin (H&E), Masson Trichrome and, immunohistochemical against NF-kB, TNF-α, and Caspase-9. IL-37 improved ECG changes, cardiac enzyme markers, and some inflammatory markers of oxidative stress in ISO-induced MI. It also improved the histopathological and immunohistochemical changes in MI. In conclusion: IL-37 might be a promising therapeutic modality in myocardial infarction.

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Angiotensin-(1-7) Central Mechanisms After ICV Infusion in Hypertensive Transgenic (mRen2)27 Rats

Cited by 8 publications

References 65 publications

Pregnancy as a Risk Factor of Severe COVID-19

Pregnancy as a Risk Factor of Severe COVID-19

Transgenic rat with overproduction of ubiquitous angiotensin-(1-7) presents neuroprotection in a model of ischemia and reperfusion

Interleukin-37 has A Promising Cardioprotective Effect on Isoproterenol-Induced Myocardial Infarction

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