Angiotensin (1–7) counteracts the negative effect of angiotensin II on insulin signalling in HUVECs

Abstract

In endothelial cells angiotensin (1-7) counteracts the negative effects of angiotensin II on insulin signalling and NO production. The balance between angiotensin II and angiotensin (1-7) could represent a key mechanism in the pathophysiological processes leading to endothelial dysfunction and insulin-resistance.

International Union of Basic and Clinical Pharmacology. XCIX. Angiotensin Receptors: Interpreters of Pathophysiological Angiotensinergic Stimuli

“…However, in C57Bl/6 mice, MAS knockout does not alter blood pressure ). Short-term Ang(1-7) infusion in normotensive rats enhanced endothelial function (Faria-Silva et al, 2005), which may be also be conserved in other species (Langeveld et al, 2008;Durand et al, 2010;Beyer et al, 2013;Jarajapu et al, 2013;Tassone et al, 2013).…”

Mas and Its Related G Protein–Coupled Receptors, Mrgprs

“…In the FVB/N mouse background, the endothelial dysfunction is associated with an increase in blood pressure , whereas in C57Bl/6 mice, no alteration of blood pressure was observed . The endothelial dysfunction associated with Mas deficiency in two genetic backgrounds is in Mas-Related Genes keeping with the improvement of endothelial function produced by short-term Ang-(1-7) infusion in normotensive rats (Faria-Silva et al, 2005) and with the improvement of Mas-mediated vascular function in many species and conditions (Langeveld et al, 2008;Durand et al, 2010;Stegbauer et al, 2011;Beyer et al, 2013;Jarajapu et al, 2013;Tassone et al, 2013).…”

Modulation of the action of insulin by angiotensin-(1–7)

“…It was found that Ang-(1-7) not only counteracted the AngII-mediated inhibition of insulin-stimulated Akt phosphorylation, but also improved the phosphorylation of other insulin-related intracellular proteins, such as AS160 and GSK-3β [86]. In a recent report, this counteraction of the inhibitory effects of AngII on insulin-induced Akt activation was confirmed using both human umbilical vein endothelial cells [140] and isolated rat soleus muscle [141]. Importantly, in skeletal muscle, Ang-(1-7) was shown to ameliorate the inhibitory effect of AngII on glucose transport activity [141].…”

“…Importantly, in skeletal muscle, Ang-(1-7) was shown to ameliorate the inhibitory effect of AngII on glucose transport activity [141]. Although the negative effects of AngII on insulin signalling are mediated by the AT 1 R, the beneficial and counteracting effect of Ang-(1-7) on the actions of AngII at this level appear to be mediated by its specific receptor Mas [92,140,141] (Figure 3A).…”