Angiotensin-converting enzyme DD genotype is associated with worse perinatal cardiorespiratory adaptation in preterm infants

Harding, David; Dhamrait, Sukhbir S.; Marlow, Neil; Whitelaw, Andrew; Gupta, Sanjay; Humphries, Steve E.; Montgomery, Hugh

doi:10.1067/s0022-3476(03)00582-1

Cited by 35 publications

(25 citation statements)

References 20 publications

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“…Both polymorphisms are thought to be functional and could influence a number of known complications of prematurity. Several studies reported adverse respiratory outcomes of preterm infants associated to the ACE-ins/del polymorphism [4][5][6] , whereas other researchers were not able to confirm these findings [7] . Furthermore, the ACEins/del polymorphism was reported to be associated with retinopathy of prematurity [8] and a reduced insulin sensitivity in healthy preterm and term neonates [9] .…”

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confidence: 40%

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Polymorphisms in the Renin-Angiotensin System and Outcome of Very-Low-Birthweight Infants

Spiegler¹,

Gilhaus²,

König

et al. 2009

Neonatology

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Background: The insertion/deletion polymorphism of the angiotensin-converting enzyme (ACE-ins/del) and the angiotensin II type 1 receptor 1166A/C polymorphism (ATR1166A/C) were reported to be associated with several unfavorable outcome parameters in preterm infants like bronchopulmonary dysplasia, persistent ductus arteriosus and impaired insulin sensitivity. Objective: To confirm the above-mentioned associations in a large cohort of very-low-birthweight (VLBW) infants. Method: Clinical data of VLBW infants were prospectively recorded. The ACE-ins/del polymorphism and the ATR1166A/C polymorphism were determined by polymerase chain reaction in 1,209 and 1,168 infants, respectively. Results: There was no significant association between ACE-ins/del or ATR1166A/C genotype and outcome parameters (death, intraventricular hemorrhage, sepsis, bronchopulmonary dysplasia, ventilation, supplemental oxygen at discharge, postnatal treatment with insulin, surgery for intestinal perforation/necrotizing enterocolitis/retinopathy of prematurity/persistent ductus arteriosus. Conclusion: Both known functional polymorphisms of the renin-angiotensin system do not seem to be associated with the outcome of VLBW infants.

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confidence: 40%

“…In a cohort of 148 preterm infants, the homozygous deletion allele of the ACE polymorphism was found in 39 infants (26%) and was associated with worse perinatal cardiorespiratory adaptation [4] . Kazzi and Quasney [5] studied 51 infants with BPD and 69 control infants.…”

Section: Discussionmentioning

confidence: 99%

Polymorphisms in the Renin-Angiotensin System and Outcome of Very-Low-Birthweight Infants

Spiegler¹,

Gilhaus²,

König

et al. 2009

Neonatology

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“…22 More recently, the DD genotype of ACE was associated with a worse severity of illness in the first 12 hours of life among preterm infants as measured by a greater need for blood pressure support, higher oxygen requirement, and a greater base deficit. 33 Whether the need for a high cardiorespiratory support early in life affects an infants' risk for development of BPD remains undetermined. The investigators did not report on the outcome of infants with regard to the development of BPD.…”

Section: Discussionmentioning

confidence: 99%

Deletion Allele of Angiotensin-Converting Enzyme is Associated with Increased Risk and Severity of Bronchopulmonary Dysplasia

Kazzi

Quasney

2005

The Journal of Pediatrics

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“…In a study to determine whether the ACE I/D genotype influences the early health of preterm infants, Harding et al [15] studied 148 preterm neonates born between 30 and 32 weeks of gestation and found that patients carrying the DD genotype were at increased risk for poor postnatal adaptation. The authors postulated that mechanisms other than profound vasoconstriction were responsible for the association between DD genotype and the severity of illness during the first 12 postnatal hours.…”

Section: Introductionmentioning

confidence: 98%

Genetic polymorphisms and risk for acute renal failure in preterm neonates

Vásárhelyi

Tóth-Heyn²,

Treszl

et al. 2004

Pediatr Nephrol

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Acute renal failure (ARF) affects about 10% of severely ill neonates. Recent studies have shown that genetic polymorphisms of proteins that play a role in neonatal physiology may contribute to individual susceptibility to both ARF and its risk factors. Our review summarizes the data collected to date. Studies have shown that the risk of preterm neonates for ARF is directly associated with a combination of high tumor necrosis factor-alpha producer and low interleukin-6 producer genotypes, as well as with low heat shock protein 72 producer genotype. Premature birth is itself the most important risk factor for a number of complications, including ARF, and recent studies have also shown an association between several maternal and fetal cytokine genetic polymorphisms and increased inflammatory response in preterm neonates. These polymorphisms could also be associated with increased risk for disorders such as sepsis and necrotizing enterocolitis, which lead to renal hypoperfusion and ARF. Genetic polymorphisms of the renin-angiotensin-aldosterone system have not been shown to directly influence risk for ARF. They may, however, be associated with patent ductus arteriosus, poor postnatal adaptation, and heart failure, which are all prevalent risk factors for ARF.

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Angiotensin-converting enzyme DD genotype is associated with worse perinatal cardiorespiratory adaptation in preterm infants

Cited by 35 publications

References 20 publications

Polymorphisms in the Renin-Angiotensin System and Outcome of Very-Low-Birthweight Infants

Polymorphisms in the Renin-Angiotensin System and Outcome of Very-Low-Birthweight Infants

Deletion Allele of Angiotensin-Converting Enzyme is Associated with Increased Risk and Severity of Bronchopulmonary Dysplasia

Genetic polymorphisms and risk for acute renal failure in preterm neonates

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