Angiotensin-converting enzyme gene I/D polymorphism and renal disease

Navis, Gerjan; Kleij, Frank G.H. van der; Zeeuw, Dick de; Jong, Paul E. de

doi:10.1007/s001099900063

Cited by 30 publications

(27 citation statements)

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“…2,3 Although the exact mechanism of the ACE gene polymorphism related to the progression of renal disease remains unclear, several studies have demonstrated a more progressive renal functional decline in patients with DD genotype of ACE gene and chronic renal failure. 12,[15][16][17] However, this relationship is controversial in some studies. 18,19 It has been suggested that DD genotype can have some impact on the rate of renal function loss, but that the impact of the genotype can be obscured by other risk factors.…”

Section: Discussionmentioning

confidence: 99%

“…Therefore, it has been suggested that high local AII concentrations as a result of deletion polymorphism of the ACE gene is associated with proteinuria in chronic renal diseases. 12 To our knowledge, there are limited studies on the possible role of ACE gene polymorphism in children with minimal change nephrotic syndrome (MCNS). The aim of this study was to investigate possible relationship between the ACE gene I/D polymorphism and clinical and laboratory findings of MCNS.…”

Section: Introductionmentioning

confidence: 99%

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DD Genotype of ACE Gene in Boys: May it be a Risk Factor for Minimal Change Nephrotic Syndrome?

2011

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It has been shown that angiotensin-converting enzyme (ACE) gene insertion/deletion (I/D) polymorphism affects the circulating and cellular levels of ACE and may be a risk factor in several renal diseases. We analyzed the association of ACE gene I/D polymorphism with the clinical presentation of minimal change nephrotic syndrome (MCNS) in a Turkish child population. This study consisted of 97 children with MCNS and 144 healthy controls. Genotyping of ACE gene was performed using polymerase chain reaction (PCR). The distributions of ACE genotypes were II in 13%, ID in 49%, and DD in 38% in patient group, and 9%, 49%, and 42% in control group, respectively. The frequency of the D allele was 63% and that of the I allele was 37% in patients. There were no relevant differences in the allele frequencies and genotypes of ACE I/D polymorphism between patients and controls. However, DD genotype was higher in boys in children with MCNS (78.4%. vs. 50.0%, p = 0.004). The frequencies of DD genotype and D allele in boys were 7.25 and 2.56 times higher than II genotype and I allele in the patient group, respectively. We suggest that DD genotype in boys may be one of the risk factors for MCNS.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

DD Genotype of ACE Gene in Boys: May it be a Risk Factor for Minimal Change Nephrotic Syndrome?

2011

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“…7). Studies have found that the DD genotype is associated with a more rapid loss of renal function in diabetic nephropathy, 23 IgA nephropathy 24 and adult polycystic kidney disease, 25 when compared to the II or DI genotypes.…”

Section: Discussionmentioning

confidence: 99%

“…6 Several studies have shown that the DD genotype is associated with more rapid progression and severity of diabetic and immunoglobulin A nephropathy (reviewed in Ref. 7). The observed beneficial effects of ACE inhibitors in experimental BMT nephropathy and the association of ACE genotype with progression of other renal diseases led us to ask whether ACE genotype is associated with loss of renal function after BMT.…”

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confidence: 99%

Loss of renal function following bone marrow transplantation: an analysis of angiotensin converting enzyme D/I polymorphism and other clinical risk factors

Juckett

Cohen

Keever-Taylor

et al. 2001

Bone Marrow Transplant

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Summary:Chronic renal failure is an acknowledged late complication of BMT. It is related to the intensive chemotherapy, radiation and supporting medications. Polymorphism in the angiotensin converting enzyme (ACE) gene is associated with progression of nephropathy caused by diabetes and IgA nephropathy. We sought to determine whether ACE genotype and other clinical factors were associated with loss of renal function after BMT. We determined the genotype of 106 adult allogeneic BMT recipients, who received a similar preparative regimen, survived 1 year, and had assessment of renal function up to 3 years after BMT. We found that the distribution of genotypes was similar to the general population; 29%, 51%, and 20% for the DD, DI, and II genotypes, respectively. There was no statistical difference in patient survival between the three groups. Among all patients, the average creatinine clearance declined from 124 (95% CI 117, 131) to 89 (95% CI 78, 100) ml/min over the 36 months after BMT. Decline in renal function over time was less for patients with the DD compared to the II genotype (P = 0.040). Renal function in patients with the DD genotype was also better than those with the DI genotype, but this was of borderline statistical significance (P = 0.055). Renal shielding reduced decline in renal function compared to no shielding (P = 0.026). We conclude that the ACE genotype does not seem to influence survival, but the DD genotype may be protective against renal injury after BMT. Furthermore, we confirm that renal shielding during TBI reduces the renal injury after BMT. Bone Marrow Transplantation (2001) The late occurrence of chronic renal failure is a known complication of allogeneic bone marrow transplantation. 1 The combined effects of intensive radiation and chemotherapy are implicated in the pathogenesis of acute and chronic renal insufficiency. Factors contributing to acute renal failure include hypotension, sepsis and the administration of nephrotoxic medications such as aminoglycoside antibiotics, cyclosporine, tacrolimus and amphotericin. A distinct syndrome of chronic renal failure after BMT termed 'bone marrow transplant nephropathy' has been described that consists of azotemia, disproportionate anemia, and hypertension. 2,3 This syndrome is thought to be due to either microvascular or renal parenchymal damage from the preparative regimen and in its most severe form resembles hemolytic uremic syndrome (HUS).Studies using animal models of BMT nephropathy have shown that angiotensin converting enzyme (ACE) inhibitors can effectively prevent and treat the syndrome. 4,5 This finding implicates the renin-angiotensin axis in the pathogenesis of the disorder. ACE is responsible for the cleavage of angiotensin I to angiotensin II, which has potent effects on vascular tone, growth and repair. The ACE gene contains a polymorphism based on the presence or absence of a 287-base pair intron. 6 The presence of the intron has been termed the 'insertion' or 'I' allele, and the absence of the intron the 'deletion' or...

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“…Kiterjedt vizsgálatokat végeztek mind kardiológiai, mind vesebeteg populációkon [6]. Egyes genotípusok kedvezőtlen prognosztikai faktorként szerepelnek a szív-ér rendszeri megbetegedés tekintetében, és sok szerző a CAN nem immunológiai rizikótényezőjeként is tekint rájuk.…”

Section: The Effect Of the I/d Polymorphism Of The Angiotensin-converunclassified

Az angiotenzinkonvertálóenzim-gén I/D polimorfizmusának hatása a vesetranszplantált betegek cardiovascularis rizikójára és a grafttúlélésre

et al. 2016

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Bevezetés: A végstádiumú vesebetegségben szenvedők kezelésében a veseátültetés hosszabb túlélést biztosít, mint a vesepótló kezelések egyéb formái. A recipiens várható túlélését leginkább a magasabb szív-ér rendszeri eredetű halá-lozás befolyásolja. A transzplantált vese károsodásának leggyakoribb oka az idült allograft-nephropathia. Célkitűzés: A szerzők a recipiens és a beültetett vese hosszú távú túlélésével egyértelmű összefüggést mutató biomarkerek azonosítását tűzték ki célul. Módszer: A retrospektív vizsgálatba 72 beteget vontak be. Meghatározták az angiotenzinkonvertálóenzim-gén I/D polimorfizmusát, az enzim aktivitását, a vesefunkciót, valamint a szív morfológiai jellemzőit. Eredmények: Az angiotenzinkonvertálóenzim-gén DD genotípusa egyaránt összefüggést mutatott az idült allograft-nephropathia és a súlyos fokú bal kamrai hypertrophia előfordulásával. A vesefunkció és a szívizom-hypertrophia mértéke között szoros összefüggést találtak. Következtetések: Eredményeik szerint az angiotenzinkonvertáló-enzim-gén I/D polimorfizmus ismerete lehetőséget ad a recipiens és a transzplantált vese túlélésének becslésére, a veszélyeztetett betegek azonosítására. Ezeknek a betegeknek a körében szükségesnek tűnik a renin-angiotenzin rendszert gátló gyógyszerek alkalmazása, együttműködésük fenntartása a gyógyszerszedés vonatkozásában. Orv. Hetil., 2016, 157(24), 938-845.Kulcsszavak: vesetranszplantáció, angiotenzinkonvertáló enzim, I/D polimorfizmus, idült allograft-nephropathia, balkamra-hypertrophiaThe effect of the I/D polymorphism of the angiotensin-converting enzyme gene on the cardiovascular risk and graft survival of kidney transplant patients Introduction: Renal transplantation provides longer life expectancy in patients with renal failure. Nonetheless, this improved life expectancy is still shorter than that for the general population. The main couse of death in renal transplant patients is cardiovascular disease, and chronic allograft nephropathy is the most significant cause of graft loss. Genetic polymorphisms of the renin angiotensin system have been implicated in both chronic allograft nephropathy and fatal cardiovascular diseases. Aim: The long term goal of the authors was to improve the survival of renal transplanted patients. The authors aimed to identify novel biomarkers which correlate with the survival of the transplant organ and the recipient with a special attention to elements of the renin-angiotensin system. Method: A retrospective clinical trial was performed involving 72 renal transplanted patients. Angiotensin-converting enzyme I/D genotypes and activity, kidney function and morphological properties of the heart were determined. Results: A significant positive correlation was found between the DD genotype of the angiotensin-converting enzíme gene, and the DD genotype predicted severe left ventricular hypertrophy. Conclusions: These findings suggest that the I/D genotypes of the angiotensin-converting enzyme gene predict not only the expected survival of the transplanted organ, but also that of...

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Angiotensin-converting enzyme gene I/D polymorphism and renal disease

Cited by 30 publications

References 97 publications

DD Genotype of ACE Gene in Boys: May it be a Risk Factor for Minimal Change Nephrotic Syndrome?

DD Genotype of ACE Gene in Boys: May it be a Risk Factor for Minimal Change Nephrotic Syndrome?

Loss of renal function following bone marrow transplantation: an analysis of angiotensin converting enzyme D/I polymorphism and other clinical risk factors

Az angiotenzinkonvertálóenzim-gén I/D polimorfizmusának hatása a vesetranszplantált betegek cardiovascularis rizikójára és a grafttúlélésre

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