Angiotensin Converting Enzyme Gene Polymorphism in Dyslipidemia and Hypertension

Abstract

Background: Hypertension and dyslipidemia have a multifactorial background based on genetic and environmental interactive factors. Increasing blood pressure (BP) and hypertension incidence have also been found to be linked with elevated blood lipids rates. Insertion/deletion (I/D) polymorphisms of the angiotensin converting enzyme (ACE) are said to be linked to pathogenesis of both hypertension and dyslipidemia.Objectives: to investigate the presence of the three genotypes of ACE gene (I/D) polymorphisms with hypertension and dyslipidemia.Subjects and methods: Participants included 30 Egyptian patients with hypertension and /or dyslipidaemia (Group I) and 20 apparently healthy controls (Group II). For all participants, DNA was isolated and amplified by polymerase chain reaction (PCR); the product was recognized by gel electrophoresis according to their size.Results: diferent ACE genotypes frequencies were detected according to the presence or absence of 287 bp fragment in intron 16; 30% for Deletion/Deletion (DD), 56.7% for Insertion/Deletion (ID) and 13.3% for Insertion/Insertion (II) in patients group, denoting that (I) allele has a significant association with hypertension and dyslipidemia (p< 0.05). Conclusions:There is increased frequency of ACE I/D and I/I, therefore, the I allele was common among Egyptian patients affected with hypertension and /or dyslipidaemia.

Association Between ACE I/D Gene Polymorphism and Dyslipidemia in Hypertensive Patients with Ischemic Heart Disease Complication Among Ethiopian Population

“…26 We also analyzed a number of conventional cardiovascular risk variables in patients with IHD and found that HTN and dyslipidemia significantly influence the occurrence of IHD. These findings agreed with research conducted in Pakistan, 23 Egypt, 27 and Iran. 28 Hypertension and dyslipidemia contribute to IHD through a number of different mechanisms.…”