Angiotensin-Converting Enzyme Gene Polymorphism Is Associated With Myocardial Infarction but Not With Development of Coronary Stenosis

Ludwig, E H; Corneli, Patrice Showers; Anderson, Jeffrey L.; Marshall, Hiram W.; Lalouel, Jean-Marc; Ward, Richard H.

doi:10.1161/01.cir.91.8.2120

Cited by 146 publications

(66 citation statements)

References 16 publications

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“…12 Since that time a lot of studies were performed in which ACE genotype was used as a tool, through association studies, to investigate the role of tissue ACE in human disease pathogenesis. [13][14][15][16][17] Taken together, the available evidence supports the notion that the DD ACE genotype adversely influences specific cardiovascular diseases but appears to do so in specific geographical areas and in particular patient subgroups. 18 This can be a possible explanation of the inconsistency of association between ACE genotype and ED.…”

Section: Introductionsupporting

confidence: 63%

Association between the insertion/deletion polymorphism of the angiotensin-converting enzyme gene and erectile dysfunction in patients with metabolic syndrome

et al. 2007

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This study was designed to investigate whether angiotensin-converting enzyme (ACE) insertion/ deletion (I/D) polymorphism is associated with erectile dysfunction (ED) in Russian men with metabolic syndrome (MS). A total of 331 men with MS were studied. All patients underwent complex evaluation including the International Index of Erectile Function (IIEF) questionnaire. The ACE I/D polymorphism was determined by polymerase chain reaction. Overall, 182 men (55.0%) had ED according to the IIEF erectile function domain score. In the ED group, the prevalence of DD genotype was found to be significantly higher compared to the non-ED group (Po0.001). In both groups, patients with DD genotype were significantly younger than patients with other genotypes (Po0.001). In addition, in the ED group, the disease affected patients with DD genotype at a significantly younger age (Po0.001). Obtained results give evidence to support the finding that the D allele is a risk factor for the micro-and macrovascular diseases.

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Section: Introductionsupporting

confidence: 63%

Association between the insertion/deletion polymorphism of the angiotensin-converting enzyme gene and erectile dysfunction in patients with metabolic syndrome

et al. 2007

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“…These results are contradictory to another report which demonstrated that the mutant deletion allele was associated with a low BMI. 24 On further comparison of the hypertensive overweight/obese and control groups in the current study, a significant difference was found between the frequency of the insertion/insertion genotype and between the allele frequencies of insertion and deletion alleles. While no significant association was found between the ACE insertion/deletion polymorphism and BMI in the hypertensives, a significant association was observed with hypertension.…”

Section: Discussionmentioning

confidence: 52%

Association of Angiotensin-Converting Enzyme and Glutathione S-Transferase Gene Polymorphisms with Body Mass Index among Hypertensive North Indians

Rizvi

Raza

Siddiqi

et al. 2015

SQUMJ

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abstract:Objectives: This study aimed to examine the association of angiotensin-converting enzyme (ACE) and glutathione S-transferase (GST) gene polymorphisms with body mass index (BMI) in hypertensive North Indians. Methods: This case-control study was carried out between May 2013 and November 2014 at the Era's Lucknow Medical College & Hospital, Lucknow, India, and included 378 subjects divided into three groups. One group constituted 253 hypertensive individuals (sustained diastolic blood pressure of >90 mmHg and systolic blood pressure of >140 mmHg) who were subcategorised according to normal (<25 kg/m 2 ) or high (≥25 kg/m 2 ) BMI. The third group consisted of 125 age-, gender-and ethnically-matched normotensive controls with a normal BMI. Gene polymorphisms were evaluated by polymerase chain reaction. The genotypic and allelic frequency distribution among both groups were analysed. Results: A significant difference was found between GST theta 1-null and GST mu 1-positive genotype frequencies among the hypertensive overweight/obese individuals and controls (P = 0.014 and 0.033, respectively). However, no difference was observed in the frequency of ACE polymorphisms. ACE insertion/insertion genotype (P = 0.006), insertion and deletion alleles (P = 0.007 each) and GST theta 1-null and GST theta 1-positive genotypes (P = 0.006 each) were found to differ significantly between hypertensive cases and controls, regardless of BMI. Conclusion: ACE and GST gene polymorphisms were not associated with BMI but were significantly associated with hypertension among the studied group of North Indians.

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“…Soluble ACE activity was measured by hydrolysis of a radiolabeled synthetic substrate, [glycine-1- 14 C]hippuryl-L-histidyl-L-leucine (3 mCi/mmol). 42 The presence of phenol red prevented the use of the fluorometric assay.…”

Section: Vascular Cell Phenotypesmentioning

confidence: 99%

“…Furthermore, cell and tissue ACE levels have also been shown to be modulated by ACE gene polymorphism in humans. 11,12 Since Cambien et al 13 first described a significant association between the I/D polymorphism and myocardial infarction, many studies have tried to examine the association of the ACE genotype, not only with ischemic heart disease 14 -17 but with a variety of conditions ranging from hypertension 18,19 to coronary artery restenosis, 14,20,21 cardiac hypertrophy, 16,22,23 pulmonary hypertension, 24 diabetes, 25 and nephropathy. 26 -28 The results of these studies are contradictory and stress the importance of experimental models for testing the impact of the ACE gene polymorphism and its associated modulation of ACE expression on the cardiovascular and renal responses to these pathological processes.…”

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confidence: 99%

Angiotensin I-Converting Enzyme Genotype Influences Arterial Response to Injury in Normotensive Rats

Challah

Villard

Philippe

et al. 1998

ATVB

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Abstract-Two normotensive strains of rat, the Lou and Brown Norway (BN) strains, have contrasting levels of plasma angiotensin-converting enzyme (ACE). To investigate the degree of genetic determination of ACE expression, a polymorphic marker of the ACE gene was analyzed in inbred rats of the two strains. The two inbred strains were shown to bear different alleles for a polymorphic marker at the ACE gene. The segregation of the alleles of this marker and the plasma ACE levels were studied in a group of F2 rats issued from a cross between Lou and BN rats. The degree of genetic determination of plasma ACE activity was estimated to be 94% in the F2 cohort. The ACE locus accounts for 74% of total plasma ACE variance. ACE activity and mRNA expression in lungs were also genetically determined. The difference observed in ACE mRNA accumulation in the lungs between the two strains was due to a difference in the transcriptional rate of the ACE gene, as shown in nuclear run-on experiments. No differences were observed in arterial blood pressure of homozygous F2 progeny. In these animals, ACE genotype did not interfere with the pressor or the depressor responses to ACE-dependent vasoactive peptides. There was a significant effect of strain on constitutive or inducible membrane or soluble ACE activity in primary cultures of vascular cells. Neointima formation in the carotid artery 14 days after balloon injury was also influenced by the genotype in F2 homozygous progeny, whereas the medial area was not. These results demonstrate that there is a close relationship between the genetically determined ACE expression and the inducibility of the ACE gene. The degree of genetic determination of ACE expression in inbred rat strains offers a unique opportunity to study the interaction between genetic and environmental determinants of ACE expression and its involvement in response to experimental cardiovascular and renal injury. (Arterioscler Thromb Vasc Biol. 1998;18:235-243.)

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Angiotensin-Converting Enzyme Gene Polymorphism Is Associated With Myocardial Infarction but Not With Development of Coronary Stenosis

Cited by 146 publications

References 16 publications

Association between the insertion/deletion polymorphism of the angiotensin-converting enzyme gene and erectile dysfunction in patients with metabolic syndrome

Association between the insertion/deletion polymorphism of the angiotensin-converting enzyme gene and erectile dysfunction in patients with metabolic syndrome

Association of Angiotensin-Converting Enzyme and Glutathione S-Transferase Gene Polymorphisms with Body Mass Index among Hypertensive North Indians

Angiotensin I-Converting Enzyme Genotype Influences Arterial Response to Injury in Normotensive Rats

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