Angiotensin Converting Enzyme Genotype Influences the Response to the Angiotensin II Receptor Antagonist Losartan in Patients with Hypertension

Nakamura, Yasuyuki; Tamaki, Shinji; Uchida, Yoshiaki; Ohmichi, Nobuyuki; Yamaoka, Osamu; Miyauchi, Nobuo; Fukuhara, Takehisa; Sayama, Harumi; Yamada, Tetsuhiro; Matsuo, Shinro; Yamada, Yutaka

doi:10.1291/hypres.27.137

Cited by 4 publications

(6 citation statements)

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“…Moore et al (2007) found that a mutation in the renin gene influenced the hypotensive effect of losartan. Nakamura et al (2004) demonstrated that the angiotensin-converting enzyme genotype may be a determinant of the response to losartan in hypertensive patients. Our study investigated a new T to C variation in the apelin promoter at position -1860.…”

Section: Discussionmentioning

confidence: 99%

Apelin polymorphism predicts blood pressure response to losartan in older Chinese women with essential hypertension

Jia¹,

C²,

Kt³

et al. 2015

Genet. Mol. Res.

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ABSTRACT. We determined whether the blood pressure response to losartan in an older Chinese population with essential hypertension was associated with apelin gene polymorphisms. We genotyped the -1860T>C polymorphism of the apelin gene in a case-control study of 222 patients with hypertension and 250 controls. Following 24 weeks of treatment with losartan (50 mg/day), reductions in systolic blood pressure were significantly different among the additive (CT vs CC vs TT), dominant (TT vs CC/CT), and recessive models (CC vs CT/TT; all P < 0.05) in women but not in men. In the additive model, the TT group showed the greatest reductions in systolic BP (23 ± 10 mmHg) after treatment. The CT group showed greater reductions in systolic BP (21 ± 11 mmHg) compared to the CC group (8 ± 3 mmHg) (P < 0.05). The reductions in systolic BP of the TT and CT/CC groups were 23 ± 10 and 19 ± 10 mmHg, respectively. The reductions in systolic BP of the CC and TT/CT groups were 8 ± 3 and 21 ± 10 mmHg, respectively. After adjustment for confounding factors, quantitative trait analysis with a 6562 J. Jia et al. ©FUNPEC-RP www.funpecrp.com.br Genetics and Molecular Research 14 (2): 6561-6568 (2015) general linear model showed that the female patients with TT genotype showed greater reductions in systolic blood pressure after 24 weeks of treatment compared to the patients with the C allele (P < 0.05). The apelin -1860T>C genotype may play an important predictive role in the response to losartan in hypertensive women.

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Section: Discussionmentioning

confidence: 99%

Apelin polymorphism predicts blood pressure response to losartan in older Chinese women with essential hypertension

Jia¹,

C²,

Kt³

et al. 2015

Genet. Mol. Res.

View full text Add to dashboard Cite

show abstract

“…For example, Nakamura et al included patients with a systolic blood pressure > 140 mmHg and/or a diastolic blood pressure > 90 mmHg and subjects included by Ohmichi et al had systolic blood pressure > 160 mmHg and diastolic blood pressure > 95 mmHg [14,49]. Patients with a higher blood pressure might benefit more from treatment with antihypertensive drugs compared to patients having lower blood pressure at baseline.…”

Section: Discussionmentioning

confidence: 99%

“…Studies investigating the ACE I/D polymorphism in relation to the effects of ATR1 blockers all showed no differences among excretion of ions or RAAS measurements among the ACE I/D genotypes before treatment, except higher levels of ACE in D allele carriers [46][47][48][49][50]. After treatment with losartan, no differences among ACE I/D genotypes on urinary sodium and potassium excretion as well as creatinine clearance and proteinuria were found in Korean patients with nephropathy (n = 99) [47].…”

Section: Ace Gene Polymorphism and Effects Of Atr1-blockersmentioning

confidence: 99%

“…Diastolic blood pressure response to losartan has been found to be associated with a larger reduction in ACE II carriers as compared to D allele carriers (reduction: II = 14.3%, ID/DD = 7.9%, p < 0.05, n = 42) [49]. This association might be explained by increased levels of ACE in D allele carriers at baseline [11][12][13][14][15][16][17]49].…”

Section: Ace Gene Polymorphism and Effects Of Atr1-blockersmentioning

confidence: 99%

“…This association might be explained by increased levels of ACE in D allele carriers at baseline [11][12][13][14][15][16][17]49]. Losartan is a competitive antagonist for the ATR1.…”

Section: Ace Gene Polymorphism and Effects Of Atr1-blockersmentioning

confidence: 99%

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