Angiotensin converting enzyme in bronchoalveolar lavage fluid in pulmonary sarcoidosis.

Pulmonary Abnormalities in Dogs with Renal Azotemia

“…Uremic human patients are at increased risk of pulmonary metastatic mineralization secondary to renal hyperparathyroidism and precipitation of calcium salts. 4,7,17 The lungs are the most common site for uremia-associated mineralizations (occurring in greater than 60% of human patients with chronic kidney failure, as well as in some patients with AKI), followed by the stomach, kidney, heart, and vessel walls. 4,18,19 Mineralization primarily occurs in the alveolar septae, as noted in dogs in this study.…”

“…[4][5][6] Clinical signs range from subtle alterations in breathing pattern to progressive dyspnea, with acute respiratory distress occurring infrequently. 7 Onset of clinical signs can be insidious, but can progress to major impairment in gas exchange and eventual cyanosis. 1,2,7 The classic radiographic abnormality in people with uremic pneumonitis is a "butterfly" or "bat-wing" pattern, with a centrally localized interstitial to alveolar infiltrate and clear lung periphery primarily affecting the right lung.…”

“…7 Onset of clinical signs can be insidious, but can progress to major impairment in gas exchange and eventual cyanosis. 1,2,7 The classic radiographic abnormality in people with uremic pneumonitis is a "butterfly" or "bat-wing" pattern, with a centrally localized interstitial to alveolar infiltrate and clear lung periphery primarily affecting the right lung. 2,8 However, severity of pulmonary dysfunction is not associated with time until death in people with end-stage renal disease.…”

Détermination de l'activité enzyme de conversion de l'angiotensine I dans le liquide céphalorachidien pour le diagnostic de la neurosarcoïdose

“…La recherche d'une activité ECA sécrétée localement participe au diagnostic diffé-rentiel de syndromes parfois difficiles à étiqueter. Ainsi, une ECA élevée a été retrouvée dans des liquides de ponction où la lésion est de nature sarcoïdosique : liquide pleural, ascite, liquide synovial... L'augmentation de l'ECA dans l'humeur aqueuse caractérise l'uvéite sarcoïdosique, et dans le liquide céphalorachidien (LCR) la neurosarcoïdose, ce qui est le propos de cet article plus spécifiquement [9,32].…”

Markers of Activity

“…Radiometric method appears a little more sensitive than fluorimetric. Perrin-Fayolle and coworkers 22 and Bauer and associates 12 have found that ACE activity in BALF reflects the activity of sarcoidosis better than SACE activity (but it is, of course, far easier to monitor progress with SACE). Sharma 23 has shown good results determining ACE activity in tears (ACE-T) of patients with ocular sarcoidosis: he thinks that ACE-T should be measured to establish the diagnosis of ocular sarcoidosis and to monitor the ex-tent and activity of granuloma load; prednisone therapy lowers ACE-T activity.…”