Angiotensin-Converting Enzyme Inhibitory Activity of Passiflora edulis f. flavicarpa and Petroselinum crispum (Mill) Fuss

Restrepo, Rodrigo

doi:10.9734/bjpr/2013/3517

Cited by 3 publications

(3 citation statements)

References 14 publications

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“…In addition, these results are confirmed by the ACE inhibitory activity results. Many other researches results confirm the role of phenolic compounds and flavonoids in the antihypertensive and ACE inhibitory activities of extracts, and these are parallel to our results (Actis‐Goretta, Ottaviani, Keen, & Fraga, ; Bai, Wu, & Xu, ; de Souza et al, ; Kwon, Vattem, & Shetty, ; Restrepo et al, ).…”

Section: Discussionsupporting

confidence: 91%

“…The determination of the ACE inhibitory activity was carried out in vitro according to the method described by Restrepo, Loango, Moncada, and Landazuri () where human blood serum was used as ACE source. The method is based on enzymatic hydrolysis of the Furilacriloil‐L‐phenylalanyl‐glycyl‐glycine, by the serum ACE, to Furilacriloil‐L‐phenyl and glycyl–glycine.…”

Section: Phytochemical Standardization Analysismentioning

confidence: 99%

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Experimental and clinical antihypertensive activity of Matricaria chamomilla extracts and their angiotensin‐converting enzyme inhibitory activity

Awaad

El‐Meligy

Zain

et al. 2018

Phytotherapy Research

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Three different extracts of Matricaria chamomilla L. were evaluated for their antihypertensive activity, these extracts were total alcohol extract (Extract 1), oil extracted (Extract 2), and water lifted after oil extraction (Extract 3). Quantitative and Qualitative analyses were carried out for all extracts. The 3 extracts were proved to be safe for human use. A single oral administration of the plant extracts (200 mg/kg) decreases both systolic and diastolic blood pressure of normotensive rats after 1, 1.5, and 2 hr. Furthermore, groups treated with the evaluated extracts (100 & 200 mg/kg) or Captopril (20 mg/kg) showed a significant reduction in the elevated blood pressure and heart rate. Extract 3 showed the most antihypertensive activity. Serum biochemical parameters and lipid profile levels of treated groups were improved in comparison with induced-hypertensive untreated rats. In evaluation of oxidative damage parameters Glutathione and superoxide dismutase (SOD) in some organs, the investigated extracts or captopril restored the amount of reduced Glutathione in tissues in addition to an increase in the activity of the SOD after a significant depletion of SOD activity. In the clinical study, there was a significant dose dependent decrease in Systolic blood pressure, Diastolic blood pressure, and heart rate compared with their basal values in both normotensive and hypertensive human volunteers after oral administration of Matricaria chamomilla beverages.

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Section: Discussionsupporting

confidence: 91%

Section: Phytochemical Standardization Analysismentioning

confidence: 99%

Experimental and clinical antihypertensive activity of Matricaria chamomilla extracts and their angiotensin‐converting enzyme inhibitory activity

Awaad

El‐Meligy

Zain

et al. 2018

Phytotherapy Research

View full text Add to dashboard Cite

show abstract

“…Moisture content was determined by AOAC 925.04, protein content was determined by the Kjeldahl method (AOAC 981.10) and lipid content was determined by Soxhlet method (AOAC 920.39). ACE activity (U/L) was analyzed based on the method of Restrepo et al (2013). Specific activity was determined based on the amount of protein (Ngo et al, 2008).…”

Section: Proximate Analysismentioning

confidence: 99%

The study of angiotensin converting enzyme isolation from crossbred rabbit lung and enzyme storage capacity in frozen conditions

Nguyen¹,

Tran²,

Vo³

2020

Food Res.

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The study was carried out to obtain angiotensin converting enzyme (ACE) with high specific activity and to evaluate the ability to maintain enzyme activity in extract products as well as in rabbit lungs using frozen condition. In the scope of the content, the study conducted an evaluation to select the appropriate extraction solvent of four solvents including acetone, ethanol, Tris-HCl and distilled water. Initially, the research results have helped determine distilled water as the suitable extraction solvent and the difference is not statistically significant compared to Tris-HCl solvent. Angiotensin converting enzyme extract that was obtained by distilled water solvent has a specific activity of 10.35 U/g protein. In addition, the study investigated the ability to maintain angiotensin converting enzyme activity in rabbit lung and crude enzyme product during frozen storage (-18±2°C). The results of the study showed that angiotensin converting enzyme activity could be maintained for 3 months in rabbit lungs and 4 months in the crude product. Besides, the study also used ammonium sulfate with different concentrations to conduct angiotensin converting enzyme collection from extract product. The results of this content help determine the use of saturated ammonium sulfate with concentrations of 50% to 60% for the highest efficiency. The precipitation process helped obtain ACE products with a purity of 4.22 times, the specific activity of 42.64 U/g protein and the recovery rate of ACE up to 29.37%.

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Identification of Hypotensive Biofunctional Compounds of Coriandrum sativum and Evaluation of Their Angiotensin‐Converting Enzyme (ACE) Inhibition Potential

Hussain

Jahan

Rahman

et al. 2018

Oxidative Medicine and Cellular Longevity

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The aim of this study was to identify and characterize the bioactive compounds of Coriandrum sativum responsible for the treatment of hypertension and to explore their mechanism of action as angiotensin-converting enzyme (ACE) inhibitors. Bioactive fractions like alkaloids, flavonoids, steroids, and tannins were extracted and evaluated for their ACE inhibition potential. Among them, only flavonoid-rich fraction showed high ACE inhibition potential with IC50 value of 28.91 ± 13.42 μg/mL. The flavonoids were characterized through LC-ESI-MS/MS. Seventeen flavonoids were identified in this fraction of Coriandrum sativum in negative ionization mode which includes pinocembrin, apigenin, pseudobaptigenin, galangin-5-methyl ether, quercetin, baicalein trimethyl ether, kaempferol dimethyl ether, pinobanksin-5-methylether-3-O-acetate, pinobanksin-3-O-pentenoate, pinobanksin-3-O-phenylpropionate, pinobanksin-3-O-pentanoate, apigenin-7-O-glucuronoide, quercetin-3-O-glucoside, apigenin-3-O-rutinoside, rutin, isorhamnetin-3-O-rutinoside, and quercetin dimethyl ether-3-O-rutinoside, while six flavonoids including daidzein, luteolin, pectolinarigenin, apigenin-C-glucoside, kaempferol-3-7-dimethyl ether-3-O-glucoside, and apigenin-7-O-(6-methyl-beta-D-glucoside) were identified in positive ionization mode. The results of this study revealed that Coriandrum sativum is a valuable functional food that possesses a number of therapeutic flavonoids with ACE inhibition potential that can manage blood pressure very efficiently.

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Angiotensin-Converting Enzyme Inhibitory Activity of Passiflora edulis f. flavicarpa and Petroselinum crispum (Mill) Fuss

Cited by 3 publications

References 14 publications

Experimental and clinical antihypertensive activity of Matricaria chamomilla extracts and their angiotensin‐converting enzyme inhibitory activity

Experimental and clinical antihypertensive activity of Matricaria chamomilla extracts and their angiotensin‐converting enzyme inhibitory activity

The study of angiotensin converting enzyme isolation from crossbred rabbit lung and enzyme storage capacity in frozen conditions

Identification of Hypotensive Biofunctional Compounds of Coriandrum sativum and Evaluation of Their Angiotensin‐Converting Enzyme (ACE) Inhibition Potential

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