Angiotensin-forming enzyme in human brain

Daul, C.B.; Heath, Robert G.; Garey, Richard E.

doi:10.1016/0028-3908(75)90068-4

Cited by 57 publications

(11 citation statements)

References 18 publications

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“…6 The presence of all these components as well as angiotensinases 7 has been reported: the existence of angiotensinogen in the brain and cerebrospinal fluid is generally accepted;* 1 " renin-like activity within the central nervous system has been reported in humans, 1 ' 5 the rat,* 1 * and dog. 1 ' ' However, the physiological significance of this enzymatic activity is controversial. 10 "" Most investigators have described angiotensin-generating activity at pH 4.5-5.0 and almost no activity at pH 7.4.…”

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confidence: 99%

“…1 "* Local production of angiotensin II (All) requires the presence of a substrate, AI releasing enzyme, and converting enzyme. 6 The presence of all these components as well as angiotensinases 7 has been reported: the existence of angiotensinogen in the brain and cerebrospinal fluid is generally accepted;* 1 " renin-like activity within the central nervous system has been reported in humans, 1 ' 5 the rat,* 1 * and dog.…”

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confidence: 99%

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Renin-like activity in the rat brain during the development of DOC-salt hypertension.

Basso¹,

Ruíz²,

Mangiarua³

et al. 1981

Hypertension

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SUMMARY Lerels and distribution of an angiotenslD-fonning enzyme, active at the physiological pH (isorenin), were determined in the central nervous system of 24 rats treated with 25 mg/kg of deoxycorticosterone (DOC) subcutaneously, twice a week, plus saline to drink during 30 days, and in 14 control animals. Different areas of the brain were excised and homogenized. Renin activity and concentration were determined by incubation of the supernatant of each homogenate at pH 7.2 alone and in the presence of an excess of renin substrate. The angiotensin generated was measured by radioimmunoassay. Concentration of the renin-like enzyme was significantly higher in the posterior hypophysis and in the brain stem of the experimental group; isorenin activity was higher in the hypothalamus, cerebral cortex, cerebellum, and brain stem of the DOC-salttreated rats than in the control rats. Changes in the angiotensin-forming enzyme in the central nervous system of experimental animals, active at physiological pH, suggest that this isoreoin system may play a role in the physiological response to DOC-salt in the rat. The significance of the brain isorenin system in the regulation of blood pressure requires further analysis.

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confidence: 99%

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confidence: 99%

Renin-like activity in the rat brain during the development of DOC-salt hypertension.

Basso¹,

Ruíz²,

Mangiarua³

et al. 1981

Hypertension

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show abstract

“…From the paper of Daul et al, 4 it is evident that there is some activity, and that the main problem of studying kinetics of isorenin with human angiotensinogen is caused by high substrate blanks due to contamination of the plasma substrate with plasma renin. If plasma angiotensinogen is obtained from nephrectomized animals, this contamination can be avoided, and it has been found that homologous plasma angiotensinogen reacts well with brain isorenin in various species.…”

Section: Brain Isoreninmentioning

confidence: 99%

Is there a brain isorenin-angiotension system?

Ganten¹

1978

Circulation Research

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“…\ . of angiotensin II (ANG II) have now been demonstrated to be present in the brain tissue of dog, 1 • 2 human, 3 and rat. 4 A functional brain RAS, independently of the peripheral circulating RAS, plays a major role in the regulation and maintenance of blood pressure and water as well as sodium balance of the body fluid.…”

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Inhibition of hypertension and salt intake by oral taurine treatment in hypertensive rats.

et al. 1987

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SUMMARY Effects of oral treatment with taurine on fluid intakes produced by renin were assessed in spontaneously hypertensive rats of the Okamoto strain (SHR). Renin injected into the preoptic area increased water intake and evoked salt (2.7% NaCl solution) intake, and angiotensin II injected into this area increased water intake, but not salt intake, in both SHR and control normotensive WistarKyoto rats (WKY). The salt intake elicited by renin, but not water intake produced by renin or angiotensin II, was potentiated hi SHR. These effects of renin and angiotensin II on fluid intakes were antagonized by previous administration of taurine or •y-aminobutyric acid into the cerebral ventricles in both strains. When SHR received water containing 3% taurine from 32 to 105 days of age, development of hypertension was inhibited. Renin administered into the preoptic area at 105 days of age caused an increase in salt intake, but the increase was markedly inhibited by the oral administration of taurine as well. These results show that salt appetite produced by centrally administered renin is exaggerated hi SHR and that development of hypertension as well as renin-induced salt appetite In SHR is inhibited by dietary taurine. human, 3 and rat. 4 A functional brain RAS, independently of the peripheral circulating RAS, plays a major role in the regulation and maintenance of blood pressure and water as well as sodium balance of the body fluid. "7 ANG II acts on the central nervous system (CNS) to produce a wide variety of physiological effects, including elevation of arterial blood pressure by increased adrenergic activity with a consequent increase in cardiac output and total peripheral resistance, increased release of vasopressin and adrenocorticotropic hormone from the pituitary, and stimulation of thirst, sodium appetite, and natriuresis.8 " 12Large populations of angiotensin receptors in the rat brain are localized in the circumventricular organs,

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Angiotensin-forming enzyme in human brain

Cited by 57 publications

References 18 publications

Renin-like activity in the rat brain during the development of DOC-salt hypertension.

Renin-like activity in the rat brain during the development of DOC-salt hypertension.

Is there a brain isorenin-angiotension system?

Inhibition of hypertension and salt intake by oral taurine treatment in hypertensive rats.

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