Angiotensin I–converting enzyme gene insertion/deletion polymorphism and endometrial human cancer in normotensive and hypertensive women

Freitas-Silva, Margarida; Pereira, Deolinda; Coelho, Constança; Bicho, Manuel; Lopes, Carlos; Medeiros, Rui

doi:10.1016/j.cancergencyto.2004.03.020

Cited by 43 publications

(24 citation statements)

References 37 publications

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“…The frequency of the I allele was 0.35 for control group, and this is different to the frequency reported in studies with other populations; in Singapore Chinese, 35 Japanese, 36 and other Chinese populations in Asia, 37,38 the prevalence of I was 0.68 according to Koh et al 25 and 0.66 for Haiman et al 26 But, it is similar in the control group of Freitas-Silva et al, 27 where the frequency of the I allele was 0.30.…”

Section: Discussionmentioning

confidence: 61%

Association between the angiotensin-converting enzyme (insertion/deletion) and angiotensin II type 1 receptor (A1166C) polymorphisms and breast cancer among Brazilian women

Correa

Noronha

Nogueira-de-Souza

et al. 2009

J Renin Angiotensin Aldosterone Syst

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Introduction. We evaluated the association between components of the renin-angiotensin system and the development of breast cancer in a case-control study by means of angiotensinconverting enzyme (ACE) insertion/deletion (I/D) and angiotensin II type 1 (AT 1 )-receptor A1166C polymorphisms. Methods. Genotyping was performed by PCR-RFLP (restriction fragment length polymorphism) or PCR (polymerase chain reaction) using genomic DNA extracted from buccal cells of subjects with (101 cases) or without (307 controls) breast cancer. Results. The frequencies of genotypes for ACE were: DD, ID and II (in %: cases: 60; 20; 20; controls: 46; 37; 17; p=0.019, χ 2 ); and for AT 1 -receptor were: AA, AC and CC (in %: cases: 65; 30; 5; controls: 51; 44; 5; p=0.114, χ 2 ). The results suggested that the A1166C polymorphism was not associated with breast cancer risk. On the other hand, for the ACE (I/D), there seemed to be different risks for cancer between cases and controls. Conclusions. The ID genotype was less frequently associated with the disease than were the DD or II; that is, women with the ID genotype were 3.1 times less likely to develop breast cancer than those with the other genotypes. The ID genotype might be protective against breast cancer and the ACE (I/D) polymorphism a possible target for developing genetic markers for breast cancer.

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Section: Discussionmentioning

confidence: 61%

Association between the angiotensin-converting enzyme (insertion/deletion) and angiotensin II type 1 receptor (A1166C) polymorphisms and breast cancer among Brazilian women

Correa

Noronha

Nogueira-de-Souza

et al. 2009

J Renin Angiotensin Aldosterone Syst

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“…4 When ACE insertion-deletion (indel) polymorphism was examined as a cancer risk marker, it was associated with gastric, endometrial, prostate and breast cancer. [5][6][7][8][9][10][11][12][13] However, three different AGTR polymorphisms presented contradictory results when studied for breast cancer. [13][14][15] For every biological system each component contributes to the overall effect; therefore, to explain any phenomenon, a more integrated approach is needed.…”

mentioning

confidence: 99%

RAS polymorphisms in cancerous and benign breast tissue

Mendizabal-Ruiz

Morales

Martinez

et al. 2010

J Renin Angiotensin Aldosterone Syst

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The renin-angiotensin system (RAS) is a hormonal signaling mechanism widely known as a blood pressure regulation system. The classic pathway begins with the release of renin (REN), an aspartyl-protease that cleaves angiotensinogen (AGT) to produce angiotensin I (AngI), which is later hydrolyzed by the angiotensin I-converting enzyme (ACE) to produce angiotensin II (AngII); this octapeptide exerts its functions through its specific receptors, angiotensin II receptor type 1 and type 2 (AGTR1 and AGTR2 respectively). 1 Most of the physiological effects such as blood vessel constriction have been attributed to the AGTR1 signaling pathway. In recent years, however, research papers have described mitogenic and angiogenic activities as well, activities that are also mediated through AGTR1. 2,3 Since angiogenesis and proliferative processes are related to the development, progression and metastasis of cancer, it is reasonable to believe that RAS may have a role in cancer. 4 When ACE insertion-deletion (indel) polymorphism was examined as a cancer risk marker, it was associated with gastric, endometrial, prostate and breast cancer. [5][6][7][8][9][10][11][12][13] However, three different AGTR polymorphisms presented contradictory results when studied for breast cancer. [13][14][15] For every biological system each component contributes to the overall effect; therefore, to explain any phenomenon, a more integrated approach is needed. To date, no study has included more than two RAS genes. With this in mind, in the present work we explored the association between breast cancer and some of the major polymorphisms of the four Abstract Recent information has revealed new roles in the angiogenic processes linked to the rennin-angiotensin system. To date few studies have been done on the association between RAS genes and cancer and the majority focus mainly on angiotensin I-converting enzyme (ACE). For breast cancer there are three reports that include the angiotensin II receptor, subtype 1 (AGTR1), only one for angiotensinogen (AGT) and none for renin gene (REN). In the present study we investigate whether REN (BglI), AGT (M235T), ACE (A245T, Indel), and AGTR1 (A1166C) are associated with breast cancer. Polymorphisms were analysed by PCR and RFPLs or sequence specific assay in three groups: breast cancer, benign breast disease (BBD) and general population. REN polymorphism shows that homozygous for A allele have an increased risk for BBD. Differences in M235T genotype frequencies were significant with less heterozygous in breast cancer. With different risk values ACE indel was associated with BBD and breast cancer. Association of AGTR1 was observed only in the breast cancer group, where C allele carriers present a reduced risk. Results of this work supports previous observations on the possible involvement of this system in breast cancer but it also suggests a role in benign disease.

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“…The primers 5'-GCC CTG CAG GTG TCT GCA GCA TGT-3' (sense) and 5'-GGA TGG CTC TCC CCG CCT TCT CTC-3' (antisense) were designed for detection of the I allele with a length of 597 bp and the D allele with a length of 319 bp. The PCR reaction was performed with the annealing temperature at 50ºC [15,23]. The G/T single nucleotide polymorphism in the GLUT1gene was identified by PCR and RFLP methods.…”

Section: Dna Analysesmentioning

confidence: 99%

Gene polymorphisms in patients with type 2 diabetes and diabetic nephropathy

et al. 2012

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A considerable variability in the incidence and prevalence of diabetic nephropathy (DN) coheres with an important contribution of multigenetic predisposition in the development of DN. Some genes, which probably participate in the pathogenesis of diabetic nephropathy, also play a role in the regulation of blood pressure, familial hyperlipidemia, familial hypertension and other diseases of the cardiovascular system. We have examined the association of diabetic nephropathy, nephropathy of non-diabetic origin, hypertension and of type 2 diabetes itself with several genetic polymorphisms (the insertion/deletion polymorphism in the gene for angiotensin-converting enzyme, the G/T polymorphism in the glucose transporter 1 gene, the G/T (894) polymorphism and the T/C (−786) polymorphism in the eNOS gene in three groups of patients with diabetes mellitus: 1) patients without diabetic nephropathy (DM); 2) patients with DN; 3) patients with nephropathy of non-diabetic origin (NDRD). Angiotensin-converting enzyme is an important factor in a development of arterial hypertension, but in our groups of Central European diabetic patients the I/D polymorphism was not associated with diabetic nephropathy. Furthermore, we have confirmed that the T/C (T786C) polymorphism in the eNOS gene is associated with metabolic syndrome including type 2 diabetes.

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Angiotensin I–converting enzyme gene insertion/deletion polymorphism and endometrial human cancer in normotensive and hypertensive women

Cited by 43 publications

References 37 publications

Association between the angiotensin-converting enzyme (insertion/deletion) and angiotensin II type 1 receptor (A1166C) polymorphisms and breast cancer among Brazilian women

Association between the angiotensin-converting enzyme (insertion/deletion) and angiotensin II type 1 receptor (A1166C) polymorphisms and breast cancer among Brazilian women

RAS polymorphisms in cancerous and benign breast tissue

Gene polymorphisms in patients with type 2 diabetes and diabetic nephropathy

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