Angiotensin-I converting enzyme gene polymorphism in Turkish type 2 diabetic patients

Ergen, Arzu; Hatemi, Hüsrev; Ağaçhan, Bedia; Çamlıca, Hakan; İsbır, Turgay

doi:10.1038/emm.2004.45

Cited by 43 publications

(10 citation statements)

References 24 publications

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“…The II (Insertion-Insertion) genotype is reported to be protective against development and progression of diabetic and non-diabetic nephropathy to chronic kidney disease [48]. Clinically, serum ACE level is useful for the evaluation of disease activity and follow-up in T2DM [31,49-52]. All previous studies in non-diabetic and diabetic nephropathies have demonstrated that the deletion polymorphism of ACE gene, particularly the homozygote DD, is a risk factor for an accelerated loss of kidney function [53].…”

Section: Reviewmentioning

confidence: 99%

Association of Genetic polymorphism of PPARγ-2, ACE, MTHFR, FABP-2 and FTO genes in risk prediction of type 2 diabetes mellitus

et al. 2013

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Type 2 diabetes mellitus (T2DM) is a non-autoimmune, complex, heterogeneous and polygenic metabolic disease condition characterized by persistent elevated blood glucose levels (hyperglycemia). India as said to be the diabetic capital of the world is likely to experience the largest increase in T2DM and a greater number of diabetic individuals in the world by the year 2030. Identification of specific genetic variations in a particular ethnic group has a critical role in understanding the risk of developing T2DM in a much efficient way in future. These genetic variations include numerous types of polymorphisms among which single nucleotide polymorphisms (SNPs) is the most frequent. SNPs are basically located within the regulatory elements of several gene sequences. There are scores of genes interacting with various environmental factors affecting various pathways and sometimes even the whole signalling network that cause diseases like T2DM. This review discusses the biomarkers for early risk prediction of T2DM. Such predictions could be used in order to understand the pathogenesis of T2DM and to better diagnostics, treatment, and eventually prevention.

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Section: Reviewmentioning

confidence: 99%

Association of Genetic polymorphism of PPARγ-2, ACE, MTHFR, FABP-2 and FTO genes in risk prediction of type 2 diabetes mellitus

et al. 2013

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“…2 The significance of genetic factors in the predisposition to this microvascular complication (retinopathy, neuropathy, etc.) can be realized from the fact that various genes have been implicated in susceptibility to diabetic nephropathy, 3,4 including the angiotensin-converting enzyme (ACE) gene of the renin-angiotensin system (RAS). ACE is a dipeptidyl carboxypeptidase that removes the C-terminal dipeptide from angiotensin I to produce the potent vasoconstrictor and growth-promoting substance angiotensin I/I.…”

Section: Introductionmentioning

confidence: 99%

Association of angiotensin-converting enzyme (ACE) and fatty acid binding protein 2 (FABP2) genes polymorphism with type 2 diabetes mellitus in Northern India

Raza

Fatima

Ahmed

et al. 2013

J Renin Angiotensin Aldosterone Syst

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Background: Type 2 diabetes mellitus (T2DM) is growing in an epidemic manner across the world with an expected doubling of the incidence to millions of affected individuals in the last decades. At present, adequate data are not available regarding the ACE and FABP2 polymorphisms and their susceptibility with T2DM cases in the North Indian population. Thus we conceived the need for further study of ACE (I/D) and FABP2 (Ala54Thr) genes polymorphism and its susceptibility to T2DM in the North Indian population. Materials and methods:In this study, a total of 300 subjects (including 190 T2DM cases and 110 controls) participated. ACE and FABP2 gene polymorphisms in the cases and controls were evaluated by polymerase chain reaction and restriction fragment length polymorphism. Results: The frequencies of ACE I/I, I/D and D/D genotypes in T2DM cases and controls were 28.73%, 55.17%, 16.09% and 13.63%, 57.95%, 28.40%, respectively. The frequencies of FABP2 Ala54Ala, Ala54Thr and Thr54Thr in T2DM cases were 18.39%, 66.66%, 14.94% and 22.72%, 61.36%, 15.90% in controls, respectively. ACE I/I genotype was significantly more frequent in cases as compared to controls (p = 0.003, χ 2 = 9.13).Conclusion: It appears that the ACE I/I genotype frequency was significantly higher in the T2DM cases as compared to the controls.

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“…Moreover, levels of total proteins (p = 0.03) in G3-CD, creatinine (p < 0.001) in G1-H and HDL-C (p = 0.03) in G2-CN were significantly different between ACE I/D genotypes (▶table 3). [11,14,15,[21][22][23]. However, one meta-analysis on Chinese population could not find any association between ACE I/D polymorphism and diabetes [24].…”

Section: Association Of Clinical Anthropometric and Biochemical Paramentioning

confidence: 99%

“…Several studies have reported the association of ACE I/D polymorphism with diabetes mellitus, hypertension and CVDs [11,14,15]. However, this association is variable when diabetes co-occurs with CVDs.…”

Section: Introductionmentioning

confidence: 99%

Association of ACE I/D Polymorphism with Risk of Diabetes in Cardiovascular Disease Patients

Hussain

Abbas

Ahmed

et al. 2019

Exp Clin Endocrinol Diabetes

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Angiotensin converting enzyme (ACE), as part of renin angiotensin aldosterone system, is involved in blood pressure regulation and control several physiological functions. Insertion/Deletion (I/D) polymorphism of ACE has pronounced effects on development of metabolic diseases like diabetes, cardiovascular diseases (CVDs) and hypertension. However, association of I/D polymorphism with risk of diabetes in CVD patients is not known. The aim of present study was to check the association of ACE I/D polymorphism with risk of diabetes in subjects with CVD. For this, 531 subjects were sampled and divided into 3 groups; G1-H (healthy controls, n=117), G2-CN (cardiac patients without diabetes, n=271) and G3-CD (cardiac patients with diabetes, n=143). Genotyping of ACE I/D polymorphism was done by polymerase chain reaction. Allelic and genotypic frequencies were in Hardy Weinberg Equilibrium (χ2=0.11, p>0.05) and revealed high prevalence of I allele (55%) among all groups. However, II genotype was more common (37%) in G3-CD group. Level of glucose was also higher in subjects with II genotype than DD genotype (12.6±6.3 mmol/L vs. 9.7±5.1 mmol/L). Logistic regression analysis revealed that ACE II genotype increase the risk of diabetes in CVD patients by ~2 times [OR=1.94, CI: 1.24–3.01, p=0.03]; however, this association did not reach the significance level when adjusted for age and gender. In conclusion, ACE I/D polymorphism influence the risk of diabetes in CVD patients and ACE II increases this risk by ~2 fold.

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Angiotensin-I converting enzyme gene polymorphism in Turkish type 2 diabetic patients

Cited by 43 publications

References 24 publications

Association of Genetic polymorphism of PPARγ-2, ACE, MTHFR, FABP-2 and FTO genes in risk prediction of type 2 diabetes mellitus

Association of Genetic polymorphism of PPARγ-2, ACE, MTHFR, FABP-2 and FTO genes in risk prediction of type 2 diabetes mellitus

Association of angiotensin-converting enzyme (ACE) and fatty acid binding protein 2 (FABP2) genes polymorphism with type 2 diabetes mellitus in Northern India

Association of ACE I/D Polymorphism with Risk of Diabetes in Cardiovascular Disease Patients

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