Angiotensin II-binding protein in adult and neonatal rat heart

Sen, Indira; Rajasekaran, Ayyappan K.

doi:10.1016/0022-2828(91)90048-q

Cited by 22 publications

(5 citation statements)

References 39 publications

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“…shown that intracellular Ang II can play an important role in gene regulation and cell communication (67) via an intracellular receptor (68,69) and that its release may be regulated by mechanical factors (70).…”

Section: Figure 12mentioning

confidence: 99%

A novel vascular smooth muscle chymase is upregulated in hypertensive rats

Guo¹,

Ju²,

Leung³

et al. 2001

J. Clin. Invest.

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Section: Figure 12mentioning

confidence: 99%

A novel vascular smooth muscle chymase is upregulated in hypertensive rats

Guo¹,

Ju²,

Leung³

et al. 2001

J. Clin. Invest.

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“…In adolescents, the elevation in blood pressure is by far the most relevant factor responsible for increased LVM [33][34][35], and epidemiological studies in children have shown that blood pressure normalization is the best predictor of LVH regression [36]. Moreover, growth of the heart is greatly dependent on RAAS [37,38] in paediatric age; furthermore, angiotensin II is the most relevant factor in increasing LVM regardless of its effects on blood pressure [39]. Therefore, it is possible that on the top of better blood pressure control, the decrease in RAAS activity contributed significantly to LVH regression.…”

Section: Discussionmentioning

confidence: 99%

Percutaneous cutting balloon angioplasty for the treatment of renovascular hypertension in children and adolescents

Salice

Mircoli

Butera

et al. 2022

Journal of Hypertension

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Objective: Percutaneous transluminal renal angioplasty (PTRA), the recommended treatment in children with renovascular hypertension (RVH), often has unsatisfactory outcomes. Cutting balloons may improve the results of angioplasty in different vascular beds with complex and resistant lesions. We retrospectively analysed the effects of percutaneous cutting balloon angioplasty (PCBA) on blood pressure, cardiac mass and renal artery acceleration time in children/adolescents referred to our centre for RVH.Patients and methods: Thirteen patients (aged 9-19 years) with renal artery stenosis (RAS) and severe hypertension were identified. RASs were focal fibromuscular (FMD) or FMD-like dysplasia (in six cases bilateral, in five associated with mid aortic syndrome). Ten patients had uncontrolled hypertension, in nine cases associated with left ventricular hypertrophy (LVH). Acceleration time was abnormal in all stenotic arteries. Eighteen PCBA were performed, in three arteries associated with stent implantation.Results: PCBA was technically successful in all individuals without major complications. In one patient, an intra-stent restenosis occurred, successfully redilated with conventional angioplasty without recurrence at 4 years distance. One year after PCBA, mean SBP and DBPs were markedly reduced from 146 AE 25 to 121 AE 10 mmHg and from 87 AE 11 to 65 AE 12 mmHg, respectively (P < 0.001 for both). At that time, hypertension was cured in seven children and controlled in five individuals. This favourable outcome was confirmed with ambulatory blood pressure measurement in four patients. At the latest follow-up, left ventricular mass and acceleration time were normal in all patients.Conclusion: PCBA proved to be a well tolerated and effective procedure that can be considered as an alternative to PTRA to treat hypertensive children/ adolescents with recurrent or resistant RAS.

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“…21 Recently, a soluble high-affinity binding protein for Ang II was localized in the cytosol of neonatal rat cardiac cells with a mass of 78 kDa. 22 Intracellular dialysis of Ang II in adult rat myocytes reduces cell communication, an effect abolished by intracellular administration of losartan. 23 Similarly, the intracellular actions of Ang II in vascular smooth muscle cells are suppressed by the AT 1 receptor antagonist candesartan.…”

Section: Ang II Receptorsmentioning

confidence: 99%

“…21 Recently, a soluble high-affinity binding protein for Ang II was localized in the cytosol of neonatal rat cardiac cells with a mass of 78 kDa. 22 26,27 suggesting that AT 2 receptors counteract the effects of AT 1 receptors. The establishment of left ventricular hypertrophy in spontaneously hypertensive rats is associated with increased expression of AT 1A and AT 1B receptors.…”

mentioning

confidence: 99%

Angiotensin II and the Heart

2000

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Abstract-The active end product of the renin-angiotensin system, angiotensin II (Ang II), through the activation of specific Ang II receptors, regulates cardiac contractility, cell coupling, and impulse propagation and is involved in cardiac remodeling, growth, and apoptosis. We review these subjects, as well as the second messengers that are involved, and the synthesis of Ang II in the heart under normal and pathological conditions. Finally, we discuss the possibility that there is an intracrine renin-angiotensin system in the heart that plays a role in the control of cell communication and inward Ca 2ϩ current. (Hypertension. 2000;35:1183-1188.)Key Words: angiotensin Ⅲ heart Ⅲ hypertrophy Ⅲ receptors, angiotensin Ⅲ renin Ⅲ signal transduction A ngiotensin (Ang) II, through the activation of specific Ang II receptors, regulates cardiac contractility, cell communication, and impulse propagation. In addition, Ang II is involved in cardiac remodeling, growth, and apoptosis. In the past 10 years, the concept of a local renin-angiotensin system (RAS) located in the heart and other organs has gradually gained support, particularly with the demonstration that elements of the RAS cascade (ie, renin, angiotensinogen, Ang I, Ang II, and angiotensin-converting enzyme [ACE]) are present in tissues. 1,2 In the present article, we review up-to-date evidence that Ang II receptor activation is related to the different actions of Ang II in the heart. We also discuss renin-and ACE-dependent generation of Ang II at cardiac tissue sites and the evidence that there is an intracrine RAS in the heart. Ang II generation through alternative pathways (eg, through cathepsin D, tonin, or chymase) as well as the cardiac effects of other angiotensin metabolites, eg, Ang III, Ang IV, and Ang-(1-7), and their receptors are outside the scope of this review and will not be discussed. Ang II ReceptorsThe effect of Ang II on cardiac tissue is related to the activation of 2 specific receptors, AT 1 and AT 2 . 3,4 The AT 1 receptor has 2 subtypes: AT 1A and AT 1B . 5 AT 1A receptors are major blood pressure regulators and potent growth stimulators in cardiomyocytes in vivo, whereas AT 1B receptors are involved in the control of vascular tone when AT 1A receptors are absent. 6 Ang II receptors are 7-transmembrane domain receptors whose primary structures have been established by molecular cloning. [7][8][9] The activation of the receptor is coupled to several intracellular proteins, starting with a G protein. 10 The receptor domains that couple to G proteins involve the second and third cytosolic loops and the proximal segment of the carboxy-terminal domain. 10 -12 In the rat, AT 1A , AT 1B , and AT 2 receptors are located on chromosomes 17, 2, and X, respectively. 11 Samyn et al 13 have demonstrated that cardiac AT 1 receptor gene expression is relatively unchanged during fetal and newborn life and that AT 2 receptor mRNA expression is high during fetal development and decreases rapidly after birth. Administration of Ang II to a rat whole embryo c...

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Angiotensin II-binding protein in adult and neonatal rat heart

Cited by 22 publications

References 39 publications

A novel vascular smooth muscle chymase is upregulated in hypertensive rats

A novel vascular smooth muscle chymase is upregulated in hypertensive rats

Percutaneous cutting balloon angioplasty for the treatment of renovascular hypertension in children and adolescents

Angiotensin II and the Heart

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