Angiotensin II-induced hypertension enhanced therapeutic efficacy of liposomal doxorubicin in tumor-bearing mice

Hattori, Yoshiyuki; Ubukata, Haruya; Kawano, Keiichi; Maitani, Yoshie

doi:10.1016/j.ijpharm.2010.10.009

Cited by 13 publications

(6 citation statements)

References 15 publications

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“…In addition, several studies have demonstrated that modulating either the tumor microcirculation or IFP can influence the micro-regional and bulk accumulation of nanoparticles, including liposomes, in solid tumors [15][16][17][18][19][20]. Modulating the tumor microenvironment is often associated with changes to both tumor blood flow (TBF) and IFP, suggesting a coupling of these properties [13,21].…”

Section: Accepted Manuscriptmentioning

confidence: 99%

The intra-tumoral relationship between microcirculation, interstitial fluid pressure and liposome accumulation

Stapleton

Milosevic

Tannock

et al. 2015

Journal of Controlled Release

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Section: Accepted Manuscriptmentioning

confidence: 99%

The intra-tumoral relationship between microcirculation, interstitial fluid pressure and liposome accumulation

Stapleton

Milosevic

Tannock

et al. 2015

Journal of Controlled Release

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“…The tumors were frozen on dry ice and sliced at 16 μm. The localizations of rhodamine-labeled lipoplexes and Hoechst 33,342 were examined using an Eclipse TS100-F microscope (Nikon, Tokyo, Japan) as described previously [16].…”

Section: Biodistribution Of Pegylated Lipoplexes and Pegylated Liposomentioning

confidence: 99%

Delivery of Plasmid DNA into Tumors by Intravenous Injection of PEGylated Cationic Lipoplexes into Tumor-Bearing Mice

Hattori¹

2016

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For systemic injection of cationic liposome/plasmid DNA (pDNA) complexes (cationic lipoplexes), polyethylene glycol (PEG)-modification (PEGylation) of lipoplexes can enhance their systemic stability. In this study, we examined whether intravenous injection of PEGylated cationic lipoplexes into tumor-bearing mice could deliver pDNA into tumor tissues and induce transgene expression. PEGylation of cationic liposomes could prevent their agglutination with erythrocytes. However, when PEGylated cationic lipoplexes were injected intravenously into tumor-bearing mice, they accumulated in tumor vascular vessels and did not exhibit transgene expression in tumors with both poor and well-developed vascularization. Furthermore, PEGylated cationic lipoplexes of CpGfree pDNA could not increase transgene expression in tumors after intravenous injection. These results suggested that PEGylation could not extravasate cationic lipoplexes from vascular vessels in tumors and abolished transgene expression although it enhanced the systemic stability of cationic lipoplexes by avoiding interactions with blood components such as erythrocytes. Successful delivery of pDNA to tumors by PEGylated cationic liposomes will require a rational strategy and the design of liposomal delivery systems to overcome the issue associated with the use of PEG.

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“…Tissue sections were examined using an inverted microscope, ECRIPS TS100 (Nikon, Tokyo, Japan) as reported previously. 16 For histological inspection, upon euthanasia after the administration of saline, ONTs (50 mg/kg) and MP (25 mg/kg), the lung was collected. The tissue was immediately frozen in dry ice.…”

Section: Distribution In Lung and Histology Studiesmentioning

confidence: 99%

Higher lung accumulation of intravenously injected organic nanotubes

Maitani¹,

Nakamura²,

Kon³

et al. 2013

IJN

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Abstract:The size and shape of intravenously injected particles can affect their biodistribution and is of importance for the development of particulated drug carrier systems. In this study, organic nanotubes (ONTs) with a carboxyl group at the surface, a length of approximately 2 µm and outer diameter of 70-90 nm, were injected intravenously into tumor-bearing mice. To use ONTs as drug carriers, the biodistribution in selected organs of ONTs postinjection was examined using irinotecan, as an entrapped water-soluble marker inside ONTs, and gadolinium-chelated ONT, as an ONT marker, and compared with that of a 3 µm fluorescently labeled spherical microparticle which was similar size to the length of ONTs. It was found that for irinotecan, its active metabolite and gadolinium-chelated ONTs were highly accumulated in the lung, but to a lower level in the liver and spleen. On the other hand, microparticles deposited less in the lung and more highly in the liver. Moreover, histologic examination showed ONTs distributed more in lung tissues in part, whereas microparticles were present in blood vessels postinjection. These preliminary results support the notion of using negatively charged ONTs as intravascular carriers to maximize accumulation in the lung whilst reducing sequestration by the liver and spleen. This finding suggested that ONTs are potential carriers for lung-targeting drug delivery.

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Angiotensin II-induced hypertension enhanced therapeutic efficacy of liposomal doxorubicin in tumor-bearing mice

Cited by 13 publications

References 15 publications

The intra-tumoral relationship between microcirculation, interstitial fluid pressure and liposome accumulation

The intra-tumoral relationship between microcirculation, interstitial fluid pressure and liposome accumulation

Delivery of Plasmid DNA into Tumors by Intravenous Injection of PEGylated Cationic Lipoplexes into Tumor-Bearing Mice

Higher lung accumulation of intravenously injected organic nanotubes

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