Angiotensin II-induced vascular endothelial cells ferroptosis via P53-ALOX12 signal axis

Liu, Chi; Shen, Yi; Cavdar, Omer; Huang, Jingqiu; Fang, Hong

doi:10.1080/10641963.2023.2180019

Cited by 15 publications

(3 citation statements)

References 14 publications

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“…Moreover, FSC + US significantly reduced the GSH compared with other groups, revealing the efficient GSH depletion ability. The ratio of GSH/GSSG is considered a powerful index of oxidative stress ( Wang D. et al, 2023 ; Liu et al, 2023 ). The results showed that in the Fe 3 O 4 @SiO 2 and FSC treatment groups, the GSH/GSSG ratio was slightly varied, while it was greatly decreased in FSC + US group ( Figure 4D ), altogether confirming the superiority of FSC sonodynamic therapy.…”

Section: Resultsmentioning

confidence: 99%

Magnetically actuated sonodynamic nanorobot collectives for potentiated ovarian cancer therapy

Zhou,

Cao,

Jiang

et al. 2024

Front. Bioeng. Biotechnol.

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Ovarian cancer presents a substantial challenge due to its high mortality and recurrence rates among gynecological tumors. Existing clinical chemotherapy treatments are notably limited by drug resistance and systemic toxic side effects caused by off target drugs. Sonodynamic therapy (SDT) has emerged as a promising approach in cancer treatment, motivating researchers to explore synergistic combinations with other therapies for enhanced efficacy. In this study, we developed magnetic sonodynamic nanorobot (Fe3O4@SiO2-Ce6, FSC) by applying a SiO2 coating onto Fe3O4 nanoparticle, followed by coupling with the sonosensitizer Ce6. The magnetic FSC nanorobot collectives could gather at fixed point and actively move to target site regulated by magnetic field. In vitro experiments revealed that the magnetic FSC nanorobot collectives enabled directional navigation to the tumor cell area under guidance. Furthermore, under low-intensity ultrasonic stimulation, FSC nanorobot collectives mediated sonodynamic therapy exhibited remarkable anti-tumor performance. These findings suggest that magnetically actuated sonodynamic nanorobot collectives hold promising potential for application in target cancer therapy.

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Section: Resultsmentioning

confidence: 99%

Magnetically actuated sonodynamic nanorobot collectives for potentiated ovarian cancer therapy

Zhou,

Cao,

Jiang

et al. 2024

Front. Bioeng. Biotechnol.

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“…The hallmark genes of Ferroptosis include Alox12, Alox12b, and Aloxe3 [38]. And iron death is highly correlated with in ammation [39,40]. Persistent accumulation of monocyte-derived macrophage leads to over-expression of ALOX5, and the accumulation of its metabolite LTB4 triggers the expression of gene promoting ferroptosis in lung epithelial cells [41].…”

Section: Discussionmentioning

confidence: 99%

Identification of Age-Related Characteristic Genes Involved in Severe COVID-19 Infection Among Elderly Patients Using Machine Learning and Immune Cell Infiltration Analysis

Li,

Zhao,

Xing

et al. 2024

Biochem Genet

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BackgroundElderly patients infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) are at higher risk of severe clinical manifestation, extended hospitalization, and increased mortality. Those patients are more likely to experience persistent symptoms and exacerbate the condition of basic diseases with long COVID-19 syndrome. However, the molecular mechanisms underlying severe COVID-19 in the elderly patients remain unclear. Our study aims to investigate the function of the interaction between disease-characteristic genes and immune cell in ltration in patients with severe COVID-19 infection.Methods COVID-19 datasets (GSE164805 and GSE180594) and aging dataset (GSE69832) were obtained from the Gene Expression Omnibus (GEO) database. The combined different expression genes (DEGs) were subjected to Gene Ontology (GO) functional enrichment analysis, Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway and Diseases Ontology (DO) functional enrichment analysis, Gene Set Enrichment Analysis (GSEA), machine learning, and immune cell in ltration analysis. ResultsGO and KEGG enrichment analysis revealed that the eight DEGs (IL23A, PTGER4, PLCB1, IL1B, CXCR1, C1QB, MX2, ALOX12) were mainly involved in in ammatory mediator regulation of TRP channels, coronavirus disease-COVID-19, and cytokine activity signaling pathways. Two-degree algorithm (LASSO and SVM-RFE) and correlation analysis showed that the seven DEGs upregulated the immune cells of macrophages M0/M1, memory B cells, gramma delta T cell, dendritic cell resting and master cell resisting. ConclusionOur study identi ed seven hallmark genes that can serve as disease-characteristic genes and target immune cells in ltrated in severe COVID-19 patients among the elderly population, which may contribute to the study of pathogenesis and the evaluation of diagnosis and prognosis in aging patients infected with severe COVID-19.

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“…Free ALOX12 oxidizes cell membrane phospholipids’ polyunsaturated fatty acid chains, leading to ferroptosis. 55 …”

Section: Ferroptosis Mechanismmentioning

confidence: 99%

Ferroptosis in Cancer Therapy: Mechanisms, Small Molecule Inducers, and Novel Approaches

Luo,

Bai,

Zhang

et al. 2024

DDDT

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Angiotensin II-induced vascular endothelial cells ferroptosis via P53-ALOX12 signal axis

Cited by 15 publications

References 14 publications

Magnetically actuated sonodynamic nanorobot collectives for potentiated ovarian cancer therapy

Magnetically actuated sonodynamic nanorobot collectives for potentiated ovarian cancer therapy

Identification of Age-Related Characteristic Genes Involved in Severe COVID-19 Infection Among Elderly Patients Using Machine Learning and Immune Cell Infiltration Analysis

Ferroptosis in Cancer Therapy: Mechanisms, Small Molecule Inducers, and Novel Approaches

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