Angiotensin II Receptor Blocker Telmisartan Prevents New-Onset Diabetes in Pre-Diabetes OLETF Rats on a High-Fat Diet: Evidence of Anti-Diabetes Action

Zhao, Zhen; Luo, Rong; Li, Lanying; Tian, Fengshi; Zheng, Xiaoya; Xiong, Hai-liang; Sun, Liting

doi:10.1016/j.jcjd.2013.03.024

Cited by 9 publications

(2 citation statements)

References 35 publications

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“…This decreased FFA level improved insulin sensitivity and reduced fat accumulation in the liver and they suggested that these effects might be linked with the capa-bility of telmisartan to activate PPAR-γ. Zhao et al 65 in the year 2013 conducted a study on high-fat diet-induced diabetic rats and found that telmisartan had increased circulating adiponectin levels with an enhanced insulin sensitivity. Proinflammatory 66 adipokines such as IL-6, TNFα induced insulin resistance in multiple insulin-sensitive tissues such as the liver and pancreas.…”

Section: Telmisartan: a Safe And Effective Alternative To Glitazar Drugsmentioning

confidence: 99%

An insight into the role of telmisartan as PPAR‐γ/α dual activator in the management of nonalcoholic fatty liver disease

Devan

Nair

Kumar

et al. 2021

Biotech and App Biochem

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Nonalcoholic fatty liver disease (NAFLD) is the most common hepatic disease. It is rapidly emerging as the frequent cause for liver transplantation with the risk of disease recurrence, even after transplantation. Clinical evidence showed an abnormally altered expression of different peroxisome proliferator-activated receptor (PPAR) isotypes (PPAR-α/γ/δ) in NAFLD with an involvement in the induction of insulin resistance, hepatic steatosis, reactive oxygen species (ROS) formation, and hepatic inflammation. Recently, several dual PPAR-γ/α agonists were developed to simultaneously achieve the insulin-sensitizing effect of PPARγ as well as lipid catabolizing effect of PPAR-α. PPAR-α activation could counterbalance the steatogenic and adipogenic effects of PPAR-γ. But most of the drugs were ended in the initial level itself due to harmful adverse effects. In the present review, we discuss the possible mechanism of telmisartan, a typical angiotensin receptor blocker with excellent safety and pharmacokinetic profile, as a PPARγ/α dual agonist in the treatment of NAFLD.

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Section: Telmisartan: a Safe And Effective Alternative To Glitazar Drugsmentioning

confidence: 99%

An insight into the role of telmisartan as PPAR‐γ/α dual activator in the management of nonalcoholic fatty liver disease

Devan

Nair

Kumar

et al. 2021

Biotech and App Biochem

View full text Add to dashboard Cite

show abstract

“…In particular, activation of the RAS/angiotensin receptors impairs insulin signaling in adipose tissue, skeletal muscle, and liver (7), and its prevention by angiotensin receptor blockade (pharmaceutically or genetically) improves glucose homeostasis (8,9). In particular, the angiotensin II type 1 receptor blocker telmisartan was previously reported to improve obesity-associated/ high-fat diet (HFD)-associated adipose tissue inflammation (10)(11)(12). Moreover, uninephrectomized rats developed fat redistribution that could be prevented by treatment with an ACE inhibitor (6).…”

mentioning

confidence: 99%

Opposing Effects of Reduced Kidney Mass on Liver and Skeletal Muscle Insulin Sensitivity in Obese Mice

et al. 2014

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Reduced kidney mass and/or function may result in multiple metabolic derangements, including insulin resistance. However, underlying mechanisms are poorly understood. Herein, we aimed to determine the impact of reduced kidney mass on glucose metabolism in lean and obese mice. To that end, 7-week-old C57BL/6J mice underwent uninephrectomy (UniNx) or sham operation. After surgery, animals were fed either a chow (standard) diet or a high-fat diet (HFD), and glucose homeostasis was assessed 20 weeks after surgery. Intraperitoneal glucose tolerance was similar in sham-operated and UniNx mice. However, insulin-stimulated glucose disposal in vivo was significantly diminished in UniNx mice, whereas insulin-stimulated glucose uptake into isolated skeletal muscle was similar in sham-operated and UniNx mice. Of note, capillary density was significantly reduced in skeletal muscle of HFD-fed UniNx mice. In contrast, hepatic insulin sensitivity was improved in UniNx mice. Furthermore, adipose tissue hypoxia-inducible factor 1α expression and inflammation were reduced in HFD-fed UniNx mice. Treatment with the angiotensin II receptor blocker telmisartan improved glucose tolerance and hepatic insulin sensitivity in HFD-fed sham-operated but not UniNx mice. In conclusion, UniNx protects from obesity-induced adipose tissue inflammation and hepatic insulin resistance, but it reduces muscle capillary density and, thus, deteriorates HFD-induced skeletal muscle glucose disposal.

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PPAR Modulation Through Posttranslational Modification Control

et al. 2021

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Angiotensin II Receptor Blocker Telmisartan Prevents New-Onset Diabetes in Pre-Diabetes OLETF Rats on a High-Fat Diet: Evidence of Anti-Diabetes Action

Cited by 9 publications

References 35 publications

An insight into the role of telmisartan as PPAR‐γ/α dual activator in the management of nonalcoholic fatty liver disease

An insight into the role of telmisartan as PPAR‐γ/α dual activator in the management of nonalcoholic fatty liver disease

Opposing Effects of Reduced Kidney Mass on Liver and Skeletal Muscle Insulin Sensitivity in Obese Mice

PPAR Modulation Through Posttranslational Modification Control

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