2011
DOI: 10.1210/en.2011-1146
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Angiotensin II Signaling Promotes Follicle Growth and Dominance in Cattle

Abstract: It is generally understood that angiotensin II (AngII) promotes follicle atresia in rats, although recent data suggested that this may not be true in cattle. In this study, we aimed to determine in vivo whether AngII alters follicle development in cattle, using intrafollicular injection of AngII or antagonist into the growing dominant follicle or the second largest subordinate follicle. Injection of saralasin, an AngII antagonist, into the growing dominant follicle inhibited follicular growth, and this inhibit… Show more

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Cited by 40 publications
(37 citation statements)
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References 52 publications
(67 reference statements)
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“…Receptors AT1 and AT2 for ANG have been found in the granulosa cells of the antral follicles and in the primordial primary and secondary follicles of sows (Shuttleworth et al 2002). Administration of an ANG inhibitor in cows avoided the growth of the predominant follicle, and decreased the concentrations of E2 (Ferreira et al 2011). Similarly, in women subjected to ovaric stimulation with human menopausal gonadotropin (HMG), concentrations of ANG were positively correlated with E2 and DPF (Jarry et al 1988).…”
Section: Discussionmentioning
confidence: 99%
“…Receptors AT1 and AT2 for ANG have been found in the granulosa cells of the antral follicles and in the primordial primary and secondary follicles of sows (Shuttleworth et al 2002). Administration of an ANG inhibitor in cows avoided the growth of the predominant follicle, and decreased the concentrations of E2 (Ferreira et al 2011). Similarly, in women subjected to ovaric stimulation with human menopausal gonadotropin (HMG), concentrations of ANG were positively correlated with E2 and DPF (Jarry et al 1988).…”
Section: Discussionmentioning
confidence: 99%
“…These two distinct pathways (endocrine and local RAS) may be present in the control of a single physiological event. In the ovary, RAS underlies important ovarian blood pressure control , Acosta et al 2000 and autocrine/paracrine signaling regulating gene expression (Acosta et al 1999, Portela et al 2008, Ferreira et al 2011a. A detailed discussion on the local RAS physiology has been presented by Paul et al (2006).…”
Section: Introductionmentioning
confidence: 99%
“…Similarly, there was no effect on mRNA expression for STAR ( Figure 3C) and the steroidogenic enzymes HDS3B2 ( Figure 3D), CYP11A1 ( Figure 3E) and CYP17A1 ( Figure 3F) between different treatments. These results suggest that Ang II does not regulate steroidogenesis in bovine theca cells during the preovulatory period, such as in follicular deviation, as first shown by FERREIRA et al (2011a) in bovine theca cells treat with saralasin. However, variances in the experimental conditions, such as the reproductive status and metabolism of the cows used for cell collection, might have accounted for the nonhomogenous findings.…”
Section: Resultsmentioning
confidence: 59%
“…In bovine, there was no effect of Ang II alone or in association with LH on androstenedione or testosterone synthesis in theca cells, neither on progesterone production induced by LH in granulosa cells (PORTELA et al, 2011). Additionally, it was observed a significant decrease in mRNA abundance for the enzyme CYP19A1 in granulosa cells of dominant follicles after intrafollicular injection of saralasin (FERREIRA et al, 2011a). Although it seems that Ang II does not stimulate the synthesis of androstenedione and testosterone in theca cells, and progesterone in granulosa cells, it might have a role in estrogen prodution in granulosa cells.…”
Section: Resultsmentioning
confidence: 90%
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