Angiotensin II stimulation of hydrogen ion secretion in the rat early proximal tubule. Modes of action, mechanism, and kinetics.

Fu-ying, Liu; Cogan, Martin G.

doi:10.1172/jci113638

Cited by 185 publications

(109 citation statements)

References 24 publications

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“…Increased dietary sodium and administration of angiotensin II in animal models have been shown to increase bicarbonate reabsorption and hydrogen secretion. 15,16 If Ն1 of these mechanisms really are involved in the blood pressure elevation, several possibilities could be suggested for the lack of significance in this study, including: (1) the SLC4A5 effects in the subjects studied were too small to be detected with the assays used; (2) the wrong measurements of the Na-Li CNT were obtained (eg, maximum velocity instead of the rate constant); (3) the NaHCO 3 transporter abnormality acts to alter blood pressure through other pathways (eg, epithelial sodium channel or some nonsodium-related mechanism); or (4) these transporters may have downstream effects on other systems that, when altered and stabilized, allow these upstream measured systems to return to normal. It appears that any serum abnormalities that might be caused by functional polymorphisms in this gene are fully compensated for by other regulatory mechanisms.…”

Section: Discussionmentioning

confidence: 99%

Sodium Bicarbonate Cotransporter Polymorphisms Are Associated With Baseline and 10-Year Follow-Up Blood Pressures

Hunt

Xin

et al. 2006

Hypertension

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Abstract-The NaHCO 3 cotransporter gene (SLC4A5) on chromosome 2 encodes a protein that transports sodium and bicarbonate across the cell membrane and regulates cellular pH. The National Heart, Lung, and Blood Institute Family Blood Pressure Program found linkage of blood pressure-related traits to the chromosomal region containing SLC4A5 and phenotype associations with single nucleotide polymorphisms (SNPs) in this gene. However, the results were inconsistent over various phenotypes and SNPs. Nevertheless, the evidence was strong enough to propose this gene as a blood pressure-related gene. To extend these findings, SLC4A5 SNPs were genotyped in an independent set of 96 Utah pedigrees of 1040 adult subjects at baseline, 760 of whom were followed longitudinally for 10 years. After adjusting for age, gender, body mass index, and polygenic correlations within pedigrees, SNP hcv1137534 was significantly associated with both systolic blood pressure and diastolic blood pressure (DBP) at baseline (unadjusted Pϭ0.009 and Pϭ0.043; respectively) and at 10-year follow-up (Pϭ0.008 and Pϭ0.007; respectively). In secondary tests of association of baseline-stressed blood pressure, hcv1137534 was borderline or significantly associated with DBP change during an isometric handgrip test (Pϭ0.054), DBP change from supine to standing (Pϭ0.020), and DBP change after a 50°tilt (Pϭ0.034). There was no evidence for compensation of abnormal SLC4A5 sodium transport by genotype-specific differences in sodium-lithium countertransport, lithium-potassium cotransport, altered plasma sodium, chloride, or CO 2 levels. Therefore, in these Utah pedigrees, the SLC4A5 gene was significantly associated with blood pressure and persisted after 10 years of follow-up. These results additionally confirm the involvement of SLC4A5 with blood pressure control, although the mechanism is still unclear.

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Section: Discussionmentioning

confidence: 99%

Sodium Bicarbonate Cotransporter Polymorphisms Are Associated With Baseline and 10-Year Follow-Up Blood Pressures

Hunt

Xin

et al. 2006

Hypertension

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“…78 In the proximal tubules, Ang II favors the expression of the H + -ATPase expression, thereby increasing transcellular sodium reabsorption through the Na + /H + exchanger. [79][80][81][82][83] As described previously, renal SLC6 members co-transport Na + and thereby participate in Na + re-absorption. A possible hypothesis is that the interaction of these Na + co-transporters with ACE2, the enzyme counter regulating Ang II amounts and effects, could be a fine tuning mechanism to control Na + reabsorption.…”

Section: 11mentioning

confidence: 99%

Collectrin and ACE2 in renal and intestinal amino acid transport

Singer¹,

Camargo²

2011

Channels

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Neutral amino acid transporters of the SLC6 family are expressed at the apical membrane of kidney and/or small intestine, where they (re-)absorb amino acids into the body. In this review we present the results concerning the dependence of their apical expression on their association to partner proteins. We will in particular focus on the situation of B(0)AT1 and B(0)AT3, which associate with members of the renin-angiotensin system (RAS), namely Tmem27 and angiotensin-converting enzyme 2 (ACE2), in a tissue specific manner. The role of this association in relation to the formation of a functional unit related to Na(+) or amino acid transport will be assessed. We will conclude with some remarks concerning the relevance of this association to Hartnup disorder, where some mutations have been shown to differentially interact with the partner proteins

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“…Ang II at concentrations of 1 to 100 pM significantly stimulates proximal sodium reabsorption, whereas higher concentrations of 0.1 to 1 µM inhibit transport (37). Various studies suggest that at physiological concentrations (1 to 100 pM) Ang II promotes sodium bicarbonate reabsorption by activation of Na + -H + exchange (38). Ang II also participates in the regulation of distal nephron acidification by stimulating the Na + -H + exchange in early and late distal segments via activation of AT 1 receptors, as well as vacuolar H + -ATPase in the late distal segment (39).…”

Section: Renal Actions Of Angiotensin IImentioning

confidence: 99%

Renal actions of angiotensin-(1-7)

Silva¹,

Baracho²,

Passaglio³

et al. 1997

Braz J Med Biol Res

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The heptapeptide angiotensin-(1-7) is considered to be a biologically active endproduct of the renin-angiotensin system. This angiotensin, which is devoid of the most known actions of angiotensin II such as induction of drinking behavior and vasoconstriction, has several selective effects in the brain and periphery. In the present article we briefly review recent evidence for a physiological role of angiotensin-(1-7) in the control of hydroelectrolyte balance.

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Angiotensin II stimulation of hydrogen ion secretion in the rat early proximal tubule. Modes of action, mechanism, and kinetics.

Cited by 185 publications

References 24 publications

Sodium Bicarbonate Cotransporter Polymorphisms Are Associated With Baseline and 10-Year Follow-Up Blood Pressures

Sodium Bicarbonate Cotransporter Polymorphisms Are Associated With Baseline and 10-Year Follow-Up Blood Pressures

Collectrin and ACE2 in renal and intestinal amino acid transport

Renal actions of angiotensin-(1-7)

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