Angiotensin II system in the nucleus tractus solitarii contributes to autonomic dysreflexia in rats with spinal cord injury

Wang, Kai; Duan, Shaoxia; Xueping, Wen; Wang, Weizhong; Fang, Shangping; Qi, Dashi; Huan, Xiang; Wang, Liwei; He, Zhenzhou

doi:10.1371/journal.pone.0181495

Cited by 3 publications

(1 citation statement)

References 37 publications

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“…A DA está presente em 70% dos indivíduos com lesões medulares altas e completas. A incidência e a seriedade são caracterizadas por diversos elementos como nível de lesão, integridade da lesão e o período após o dano 13,14…”

Section: Conceituação Da Disreflexia Autonômicaunclassified

Conceitos, manifestações clínicas e cuidados imediatos na disreflexia autonômica

et al. 2018

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RESUMOObjetivo: revisar a literatura a respeito da disreflexia autonômica e apresentar conceitos, manifestações clínicas e cuidados imediatos diante dessa síndrome. Método: revisão integrativa da literatura realizada no período de maio a junho de 2018. Para a busca de dados foram utilizadas as bases de dados SciELO, PubMed e Medline. Resultados: foram selecionados quinze artigos publicados no período de 2013-2018, em português, espanhol e inglês, que contemplaram em seus títulos e/ou resumos/conteúdo o termo disreflexia autonômica e/ou reabilitação e/ou traumatismo da medula espinal e/ou seus respectivos unitermos, disponibilizados na íntegra. Quanto ao ano de publicação, observou-se que 33,33% dos artigos selecionados foram publicados em 2017; em relação ao idioma de publicação, a língua inglesa predomina em 73,33% deles; no que tange ao canal de publicação, a revista The Journal of Spinal Cord Medicine apresenta 20% dos artigos escolhidos. Quanto às abordagens dos estudos, verificou-se a determinação de conceitos, manifestações clínicas e cuidados imediatos como temáticas mais apresentadas. Conclusão: foi possível observar que a disreflexia autonômica é uma síndrome de grandes limitações, fatores etiológicos e necessidades de cuidados especializados. Vale mencionar que há uma grande escassez de estudos sobre o tema. ORCID ID: https://orcid.org/0000-0002-6559-9558Este artigo está licenciado sob forma de uma licença Creative Commons Atribuição 4.0 Internacional, que permite uso irrestrito, distribuição e reprodução em qualquer meio, desde que a publicação original seja corretamente citada Vasconcelos LA, Souza LKA, Moura RF, Freire LPV, Soares LMMM. Conceitos, manifestações clínicas.ABSTRACT Objective: to review the literature on autonomic dysreflexia and to present concepts, clinical manifestations and immediate care before this syndrome. Method: it is an integrative literature review, performed in the period from may to june 2018. Data search was performed using the SciELO, PubMed and Medline databases. Results: fifteen articles published in the period of 2013-2018 in Portuguese, Spanish and English were selected, which included in their titles and/or abstracts/contents the term autonomic dysreflexia and/or rehabilitation and/or spinal cord injuries and/ or their respective uniterms, available in full. As for the year of publication, it was observed that 33.33% of the articles selected were published in 2017; in relation to the language of publication, the English language predominates in 73.33% of them; with regard to the publication channel, The Journal of Spinal Cord Medicine presents 20% of the articles chosen. Regarding the approaches of the studies, the determination of concepts, clinical manifestations and immediate care were the most presented themes verified. Conclusion: it was possible to observe that autonomic dysreflexia is a syndrome of major limitations, etiological factors and specialized care needs. It is worth mentioning that there is a great shortage of studies on the subject. Descriptors: Aut...

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Section: Conceituação Da Disreflexia Autonômicaunclassified

Conceitos, manifestações clínicas e cuidados imediatos na disreflexia autonômica

et al. 2018

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Hemorrhage and Locomotor Deficits Induced by Pain Input after Spinal Cord Injury Are Partially Mediated by Changes in Hemodynamics

Strain

Johnston

Baine

et al. 2021

Journal of Neurotrauma

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Autonomic Dysreflexia in Spinal Cord Injury: Mechanisms and Prospective Therapeutic Targets

Trueblood,

Singh,

Cusimano

et al. 2023

Neuroscientist

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High-level spinal cord injury (SCI) often results in cardiovascular dysfunction, especially the development of autonomic dysreflexia. This disorder, characterized as an episode of hypertension accompanied by bradycardia in response to visceral or somatic stimuli, causes substantial discomfort and potentially life-threatening symptoms. The neural mechanisms underlying this dysautonomia include a loss of supraspinal control to spinal sympathetic neurons, maladaptive plasticity of sensory inputs and propriospinal interneurons, and excessive discharge of sympathetic preganglionic neurons. While neural control of cardiovascular function is largely disrupted after SCI, the renin-angiotensin system (RAS), which mediates blood pressure through hormonal mechanisms, is up-regulated after injury. Whether the RAS engages in autonomic dysreflexia, however, is still controversial. Regarding therapeutics, transplantation of embryonic presympathetic neurons, collected from the brainstem or more specific raphe regions, into the injured spinal cord may reestablish supraspinal regulation of sympathetic activity for cardiovascular improvement. This treatment reduces the occurrence of spontaneous autonomic dysreflexia and the severity of artificially triggered dysreflexic responses in rodent SCI models. Though transplanting early-stage neurons improves neural regulation of blood pressure, hormonal regulation remains high and baroreflex dysfunction persists. Therefore, cell transplantation combined with selected RAS inhibition may enhance neuroendocrine homeostasis for cardiovascular recovery after SCI.

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Angiotensin II system in the nucleus tractus solitarii contributes to autonomic dysreflexia in rats with spinal cord injury

Cited by 3 publications

References 37 publications

Conceitos, manifestações clínicas e cuidados imediatos na disreflexia autonômica

Conceitos, manifestações clínicas e cuidados imediatos na disreflexia autonômica

Hemorrhage and Locomotor Deficits Induced by Pain Input after Spinal Cord Injury Are Partially Mediated by Changes in Hemodynamics

Autonomic Dysreflexia in Spinal Cord Injury: Mechanisms and Prospective Therapeutic Targets

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