Angiotensin II type 1 receptor gene polymorphism and essential hypertension in Serbian population

Stanković, Aleksandra; Živković, Maja; Glišić, Sanja; Alavantić, Dragan

doi:10.1016/s0009-8981(02)00340-6

Cited by 34 publications

(26 citation statements)

References 13 publications

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“…Despite all the efforts, the role of the AGTR 1 gene locus still remains controversial. In a study conducted by Stankovic et al, 16) the CC genotype influenced the risk of essential hypertension in a gender-specific manner in the Serbian population.…”

Section: Discussionmentioning

confidence: 95%

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Polymorphism of the Angiotensin II Type 1 Receptor A1166C in Korean Hypertensive Adolescents

2008

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Background and Objectives:The renin-angiotensin system (RAS) is a major regulator of blood pressure. The angiotensin II receptor type 1 (AGTR 1) A1166C has been extensively studied in searching for their involvement in the development of hypertension. The aim of this study was to determine the association of the AGTR 1 A1166C marker with essential hypertension in Korean adolescents. Subjects and Methods: Forty hypertensive adolescents were included in this study. The obesity index (OI) and body mass index (BMI) of the subjects were calculated. Blood pressure was measured at the resting state by oscillometric methods. The serum aldosterone, renin, insulin, angiotensin converting enzyme (ACE), homocysteine, vitamin B 12 and folate levels were measured. The carotid intima-media thickness (IMT) and diameter and the brachial-ankle pulse wave velocity (baPWV) were evaluated by ultrasound. Polymerase chain reaction (PCR) was conducted to amplify the DNA of each of the study subjects to analyze the polymorphism of AGTR 1 A1166C. Results: The genotypic frequency of AA was 87.5%, that for adenylate cyclase (AC) was 12.5% and no CC type was detected. The serum homocysteine level was higher in the subjects with the AC genotype than that in the subjects with the AA genotype (11.9±2.9 umol/L vs 17.1±4.2 umol/L, respectively). The carotid IMT of the subjects with the AA genotype was greater than that of the subjects with the AC genotype (5.0±0.1 mm vs 8.0±0.2 mm, respectively). Conclusion: In conclusion, the A1166C mutation group had a significantly greater carotid IMT and higher homocysteine levels than the group with the normal genotype of AGTR 1. The AC genotype of A1166C may be useful to predict the presence of early coronary artery disease in hypertensive adolescents. More investigation is necessary to clarify the relation between the A1166C gene and its involvement with coronary artery disease in hypertensive Korean adolescents.

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Section: Discussionmentioning

confidence: 95%

“…15) Angiotensin interacts with at least two receptor subtypes, AGTR 1 and AGTR 2. 16) Many of the deleterious effects of angiotensin II are thought to be mediated through interaction with AGTR 1.…”

Section: Discussionmentioning

confidence: 99%

Polymorphism of the Angiotensin II Type 1 Receptor A1166C in Korean Hypertensive Adolescents

2008

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“…Association with hypertension was established in a certain subgroups of patients, e.g. only in subjects with severe, early onset, form of disease [142] and in long-term-treated subjects and/or with a family history of hypertension (HT) [143,144] or in subjects with hypercholesterolaemia [145] or in males only [146]. A systematic review and a meta-analysis of the rs5186 variant failed to present sufficient evidence that polymorphisms in the AT1R gene are risk factors for hypertension [147].…”

Section: Main Ras Molecules In Atherosclerosis Through the Magnifyingmentioning

confidence: 99%

Involvement of the Renin‐Angiotensin System in Atherosclerosis

Kolaković¹,

Živković²,

Stanković³

2017

Renin-Angiotensin System - Past, Present and Future

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The renin-angiotensin system (RAS) is a well known for its role in the regulation of the blood pressure (BP). Angiotensin II (Ang II), the main mediator of the RAS, may act either, as a systemic molecule or a locally produced factor. Within the vessel wall it has significant proinflammatory role by inducing the oxidative stress, secretion of inflammatory cytokines and adhesion molecules. Ang II could trigger proliferation of vascular smooth muscle cells (VSMC) and its migration to the outer layer of the vessel wall. It could induce the release of matrix metalloproteinase (MMPs), from human VSMC and thus increase susceptibility to rupture of atherosclerotic lesions. Binding of Ang II to AT1R/AT2R could have opposing actions in vascular injury. The ACE2/Ang (1-7)/Mas axis of the RAS also opposes the unfavourable actions of ACE/Ang II/ATR1 axis. Inhibition of RAS could reduce inflammation-associated processes in vasculature, independently of lowering BP. RAS is significantly modulated by the genes coding for this system. Certain genetic variants (SNPs) in the RAS genes have been denoted as the functional ones and have been associated with hypertension, cardiovascular phenotypes and atherosclerosis. Also, the genetic components of the RAS interfere with the regulators of gene expression by microRNAs (miRs).

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“…The pathogenic implications of these polymorphisms have been investigated and associated with hypertension (2,5,6), left ventricular hypertrophy (7-9), coronary heart disease risk (10), and congenital urinary anomalies (3,11,12).…”

Section: Introductionmentioning

confidence: 99%

AT1 receptor A1166C and AT2 receptor –1332A/G gene polymorphisms: Efficient genotyping by single‐tube PCR

Živković

Stanković

Alavantić

2005

Clinical Laboratory Analysis

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Angiotensin II type 1 receptor (AT1) and angiotensin II type 2 receptor (AT2) genes have been investigated in recent years as potential etiologic candidates for cardiovascular and renal diseases. The pathogenic implications of AT1 A1166C and AT2 A-1332G gene polymorphisms have been shown. Here we describe a rapid and reliable method for detecting both AT1 and AT2 gene polymorphisms by a single-tube PCR, to reduce analysis time and simplify the genotyping procedure. In contrast to previously described methods, our method does not require hybridization, primer extension, or nested PCR for genotyping. In most previous studies concerning gene polymorphisms of RAS, both AT1 and AT2 receptor gene polymorphisms were investigated. The advantage of our method is that it makes it possible to detect both of these polymorphisms in a duplex PCR. The procedure described is convenient for routine laboratory use with manual sample processing, and offers the potential for further automation as well. Its simplicity makes it practical for large-scale screening of individuals and families at risk for cardiovascular or renal diseases.

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Angiotensin II type 1 receptor gene polymorphism and essential hypertension in Serbian population

Cited by 34 publications

References 13 publications

Polymorphism of the Angiotensin II Type 1 Receptor A1166C in Korean Hypertensive Adolescents

Polymorphism of the Angiotensin II Type 1 Receptor A1166C in Korean Hypertensive Adolescents

Involvement of the Renin‐Angiotensin System in Atherosclerosis

AT1 receptor A1166C and AT2 receptor –1332A/G gene polymorphisms: Efficient genotyping by single‐tube PCR

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