Angiotensin receptor-neprilysin inhibitor improves coronary collateral perfusion

Li, Kangbo; Kratzmann, Victoria; Dai, Mengjun; Gatzke, Nora; Ročić, Petra; Bramlage, Peter; Grisk, Olaf; Lubomirov, Lubomir T.; Hoffmeister, Meike; Lauxmann, Martin A.; Ritter, Oliver; Buschmann, Eva; Bäder, Michael; Persson, Anja Bondke; Buschmann, Ivo; Hillmeister, Philipp

doi:10.3389/fcvm.2022.981333

Cited by 2 publications

(1 citation statement)

References 69 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Furthermore, nitric oxide (NO) has been shown to inhibit telomere attrition by regulating telomerase activity. The imbalance between NO and reactive oxygen species (ROS) leads to endothelial senescence and systemic vascular dysfunction [41].…”

Section: Discussionmentioning

confidence: 99%

Exploring genetic associations between leukocyte telomere length and hypertrophic cardiomyopathy using mendelian randomization

Yan,

Wang,

et al. 2024

Preprint

View full text Add to dashboard Cite

In this study, we conducted a bidirectional two-sample Mendelian randomization (MR) analysis to explore potential associations between leukocyte telomere length (LTL) and hypertrophic cardiomyopathy (HCM) using the summary data from a genome-wide association study (GWAS). LTL (n = 472,174), HCM (n = 218792), heart failure (HF) (n = 218792), and HCM with HF (HCM-HF) (n = 218540) were sampled from the GWAS database. Various methods such as MR-Egger, inverse variance weighting (IVW), and weighted median were employed to estimate causal effects. In the forward MR analysis, MR results indicated that shorter LTL might be associated with an increased risk of HCM (IVW: OR = 1.94, 95% CI: 1.19–3.16, p = 0.008), HF (IVW: OR = 1.14, 95% CI: 1.01–1.29, p = 0.035) and HCM-HF (IVW: OR = 2.03, 95% CI: 1.05–3.93, p = 0.036). Additionally, the reverse MR analysis did not reveal any significant causal effects. A shorter LTL might be associated with a higher risk of developing HCM, thus offering a basis for subsequent clinical investigations into the causal relationship between LTL and HCM.

show abstract

Section: Discussionmentioning

confidence: 99%

Exploring genetic associations between leukocyte telomere length and hypertrophic cardiomyopathy using mendelian randomization

Yan,

Wang,

et al. 2024

Preprint

View full text Add to dashboard Cite

show abstract

Association of endothelial function and lower extremity perfusion in peripheral artery disease

Li,

Dai,

Sacirovic

et al. 2024

Vasa

View full text Add to dashboard Cite

Summary: Background: The current study aims to investigate the association between endothelial function and lower extremity perfusion in patients with peripheral artery disease (PAD). Patients and methods: In total 229 patients with PAD (Rutherford stage 0–3) were enrolled in the current study. Endothelial function was assessed by measuring flow-mediated dilation (FMD) and endothelial cell proliferation capacity (ECPC). Lower extremity perfusion was assessed by measuring oscillometry-based ankle brachial index (oABI) and pulse wave index (PWI). In addition, carotid intima-media-thickness (cIMT) was also measured as a surrogate marker for atherosclerosis. Correlations between FMD, ECPC, oABI, PWI, and cIMT were analysed using Pearson correlation coefficient. The relationship between the above variables and the severity of PAD was investigated using ordinal logistic regression analysis. Results: Correlation analysis showed that FMD negatively associated with PWI (r = –0.183, p = 0.005), ECPC positively associated with oABI (r = 0.162, p = 0.014), and oABI negatively associated with PWI (r = –0.264, p < 0.001). Ordinal logistic regression analysis showed that ECPC ( β = –0.009, p = 0.048), oABI ( β = -5.290, p < 0.001), and age ( β = −0.058, p = 0.002) negatively associated with the PAD Rutherford stages. In addition, PWI ( β = 0.006, p < 0.001), cIMT ( β = 18.363, p = 0.043) positively associated with the PAD Rutherford stages. Conclusions: Endothelial function significantly associates with lower extremity perfusion in patients with PAD, and both are related to the severity of PAD.

show abstract

Angiotensin receptor-neprilysin inhibitor improves coronary collateral perfusion

Cited by 2 publications

References 69 publications

Exploring genetic associations between leukocyte telomere length and hypertrophic cardiomyopathy using mendelian randomization

Exploring genetic associations between leukocyte telomere length and hypertrophic cardiomyopathy using mendelian randomization

Association of endothelial function and lower extremity perfusion in peripheral artery disease

Contact Info

Product

Resources

About