Angiotropic lymphoma (intravascular large cell lymphoma) presenting with cauda equina syndrome

Lacomis, David; Smith, Thomas W.; Long, Randall R.

doi:10.1016/0303-8467(92)90180-b

Cited by 15 publications

(11 citation statements)

References 7 publications

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“…14 To our knowledge muscle biopsy has been diagnostic in 13 out of 18 patients (72%);2-5 7-9 12 13 15-22 most positive cases had neurogenic weakness in the legs (table) whereas myalgia or creatine kinase increases were rarely detected. In our patient haemostasis caused by flaccid paralysis may have predisposed to lymphoma cell nesting.…”

Section: Discussionmentioning

confidence: 88%

Intravascular lymphomatosis presenting as an ascending cauda equina: conus medullaris syndrome: remission after biweekly CHOP therapy

Nakahara

Saito

Muroi

et al. 1999

Journal of Neurology, Neurosurgery & Psychiatry

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A 63 year old man developed dysaesthesia in the legs followed by a subacute ascending flaccid paraparesis with sacral sensory and autonomic involvement. Intravascular lymphomatosis (IVL) was favoured by the presence of low grade fever and raised serum C reactive protein, CSF pleocytosis, raised lymphoma markers (serum LDH, soluble IL-2 receptor), and steroid responsiveness. Only muscle, among several organ biopsies, confirmed IVL. A cytogenetic study of the bone marrow showed chromosome 6 monosomy, as previously reported. The monosomy of chromosome 19, which bears the intercellular cell adhesion molecule-1, newly found in this case, may be related to the unique tumour embolisation of IVL. The CHOP regimen (six courses in 12 weeks) using granulocyte colony stimulating factor (G-CSF) led to gradual resolution of myeloradiculopathy and laboratory supported remission lasting for more than 13 months. The biweekly CHOP with G-CSF support may be a choice of chemotherapy in averting rapidly fatal IVL.

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Section: Discussionmentioning

confidence: 88%

Intravascular lymphomatosis presenting as an ascending cauda equina: conus medullaris syndrome: remission after biweekly CHOP therapy

Nakahara

Saito

Muroi

et al. 1999

Journal of Neurology, Neurosurgery & Psychiatry

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“…In addition, previous studies have not addressed peripheral nerve involvement in patients with IVL, 3,4,21 although some case reports have described peripheral nerve involvement. [24][25][26][27] NL is a rare clinical entity that has been described primarily in case reports and small case series. Given the extreme rarity of both IVL and NL, the current study highlights the high incidence of NL in patients with IVL.…”

Section: Discussionmentioning

confidence: 99%

High frequency of neurolymphomatosis as a relapse disease of intravascular large B‐cell lymphoma

Matsue

Hayama

Iwama

et al. 2011

Cancer

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BACKGROUND: Intravascular large B-cell lymphoma (IVL) is characterized by lymphoma cell proliferation in the lumina of small vessels in various organs. A high incidence of neurologic symptoms associated with the central nervous system has been reported, but peripheral nerve involvement (neurolymphomatosis [NL]) rarely has been described. METHODS: The medical records from patients who were diagnosed with IVL over the past 4 years were reviewed. A diagnosis of NL was made based on the combination of neurologic symptoms and their correspondence with imaging studies, such as magnetic resonance imaging (MRI), 18 F-fluoro-2-deoxy-D-glucose (FDG)-positron emission tomography/computed tomography (PET/CT), and/or the histologic confirmation of lymphoma cells within the peripheral nerves, nerve root/plexuses, or cranial nerves. RESULTS: Four patients with NL were identified among 11 patients who had IVL. All cases of NL occurred as relapsed disease during or shortly after the completion of chemotherapy. Although MRI studies of the brains and whole spines revealed nerve infiltration by gadolinium enhancement in 2 patients, the technology was not sensitive enough to detect such infiltration in the remaining 2 patients. In contrast, FDG-PET/CT studies successfully revealed cranial or peripheral nerve lesions in all 4 patients and was useful for evaluating therapeutic response. Patients received treatment with high-dose methotrexate with or without other systemic chemotherapy, which achieved varied success. Further studies will be needed to determine the optimal treatment. CONCLUSIONS: Considering the rarity of IVL and NL, the current observations suggested that IVL may have a predilection not only for the vessels but also for both the central and peripheral nervous systems. Cancer 2011;117:4512-

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“…Primary pulmonary intravascular lymphomatosis is extremely rare. As well as the 101 cases identified by Domizio et al 10 in 1989, we had found an additional 103 cases of intravascular lymphomatosis [11][12][13][14][15][17][18][19][20][21][22][23]25,[27][28][29][30][31][32][33][34][40][41][42][43][44][45][46][47][48][49][50][51][52][53][54][55][56][57][58][59] . Among these 204 cases, there were only 10 cases which presented with predominant pulmonary symptoms and lacked neurological and cutaneous symptoms and signs [11][12][13][14][15][16][17] although most cases of...…”

Section: Discussionmentioning

confidence: 99%

Intravascular lymphomatosis: a clinicopathological study of two cases presenting as an interstitial lung disease

Han

et al. 1997

Histopathology

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Angiotropic lymphoma (intravascular large cell lymphoma) presenting with cauda equina syndrome

Cited by 15 publications

References 7 publications

Intravascular lymphomatosis presenting as an ascending cauda equina: conus medullaris syndrome: remission after biweekly CHOP therapy

Intravascular lymphomatosis presenting as an ascending cauda equina: conus medullaris syndrome: remission after biweekly CHOP therapy

High frequency of neurolymphomatosis as a relapse disease of intravascular large B‐cell lymphoma

Intravascular lymphomatosis: a clinicopathological study of two cases presenting as an interstitial lung disease

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