Angle β combined with FeNO and FEV1/FVC% for the detection of asthma in school-aged children

Shi, Hongke; Su, Aifang; Dai, Fuli; Wang, Xiufang; Zhang, Yan; Zheng, Yuehong; Cai, Chunling; Wang, Xiao

doi:10.1080/02770903.2021.1874979

Cited by 2 publications

(3 citation statements)

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“…Third, this study only examined pulmonary function test parameters and did not use other indicators for a more comprehensive and long-term assessment of changes before and after standardized treatment in school-aged children with asthma. Our previous study confirmed the value of the FeNO test in the management of asthma in school-aged children ( 23 ). In the next phase of this work, we will increase the sample size, examine more inflammatory indicators, and conduct a longer study to examine FeNO levels in 6- to 12-year-old children with asthma at different ages, assess the value of FeNO levels at different ages in the application of standardized asthma treatment, and provide a reference for the precise treatment of children with asthma.…”

Section: Discussionsupporting

confidence: 86%

“…FeNO measurements have been suggested to be of great clinical utility as a form of noninvasive testing for respiratory diseases, particularly asthma ( 21 ). Research has shown that FeNO measurement can assist in diagnosing asthma in children ( 5 , 7 , 9 , 22 , 23 ), evaluating treatment efficacy ( 5 , 24 ), and managing asthma ( 5 , 24 , 25 ). The influence of age on FeNO levels has been demonstrated in recent years ( 5 , 13 – 15 ), but more detailed reference standards for clinical use are currently lacking.…”

Section: Discussionmentioning

confidence: 99%

“…In clinical work, physicians design treatment regimens for patients by referring to their FeNO levels ( 25 , 39 , 40 ). Some studies have confirmed the clinical utility of the FeNO test in diagnosis ( 23 ) or customized treatment ( 41 ), but its functions are still debated. The diagnosis and treatment of children with asthma are currently based on signs and symptoms ( 6 , 10 ).…”

Section: Discussionmentioning

confidence: 99%

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Can the Chinese study on the normal range of FeNO in children evaluate standardized asthma treatment efficacy in 6- to 12-year-old children?

Yang,

Cai,

et al. 2023

Front. Pediatr.

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ObjectiveBy examining fractional exhaled nitric oxide (FeNO) levels and performing pulmonary function testing, this study explored whether the multicenter study on the normal range of FeNO in children in China can be used to evaluate standardized treatment efficacy in 6- to 12-year-old children with asthma.MethodsA total of 115 children aged 6–12 years old who were first diagnosed with asthma and received standardized asthma treatment from April 2018 to July 2022 were selected. According to the FeNO level at the first visit, the subjects were divided into different high- and low-FeNO groups according to the American Thoracic Society (ATS) guidelines and the Chinese multicenter study recommendations. The consistency of the two grouping methods and the differences between the high- and low-FeNO groups were compared after standardized treatment. The grouping method that was the most suitable for children in the cross group was discussed.Results(i) There was fair consistency between the Chinese multicenter study recommendations and the ATS guidelines regarding the classification of high- and low-FeNO groups (Kappa = 0.338). (ii) Repeated-measures ANOVA showed that the level of improvement in FVC%, FEV1%, FEF25%, FEF50%, and FeNO in the American high- and low-FeNO groups differed with the duration of therapy (P < 0.05), however, there was no significant difference between the Chinese groups. (iii) FEV1% and FeNO improved more after treatment in the fixed high-FeNO group than in the cross group (P < 0.05).ConclusionThe Chinese multicenter study on the normal range of FeNO in children in China has a limited role in evaluating standardized asthma treatment efficacy in 6- to 12-year-old children. The ATS guidelines are currently recommended for clinical assessment of asthma treatment efficacy.

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Section: Discussionsupporting

confidence: 86%